Use of mean platelet volume in the assessment of intrauterine infection in newborns with combined thrombocytopenia and leukopenia at birth

Chen, Chu-Yen; Essien, Mmeyeneabasi D.; Johnson, Amy J.; Lee, Gene; Chou, Fu‐Sheng

doi:10.1080/14767058.2019.1608174

Cited by 4 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, PROM is not associated with MPV as in a previous study [27]. Recently, a retrospective study has reported significant correlation between MPV and intrauterine infection in neonates with thrombocytopenia and leukopenia at birth [23,28]. Since CAM was indicative of intrauterine infection, our results are consonant with previous studies.…”

Section: Plos Onesupporting

confidence: 89%

Perinatal factors affecting platelet parameters in late preterm and term neonates

Ohto

Nollet

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

Platelets parameters including platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) are associated with various physiological and pathological functions in various disease. However, few studies have addressed whether perinatal factors may be associated with platelet parameters at birth in a large cohort of late preterm and term neonates. The aim of this study to investigate perinatal factors affecting platelet parameters in late preterm and term neonates. We retrospectively investigated platelet parameters including PLT, PCT, MPV, and PDW on the first day of life in 142 late preterm and 258 term neonates admitted to our NICU from 2006 through 2020. PLT, MPV, PCT, PDW on Day 0 did not significantly differ between the two groups. In term neonates, multivariate analysis revealed that PCT correlated with being small for gestational age (SGA) (β = -0.168, P = 0.006), pregnancy induced hypertension (PIH) (β = -0.135, P = 0.026) and male sex (β = -0.185, P = 0.002). PLT was associated with SGA (β = -0.186, P = 0.002), PIH (β = -0.137, P = 0.024) and male sex (β = -0.166, P = 0.006). In late preterm neonates, multivariate analysis revealed that PLT were associated with PIH, whereas no factors associated with PDW and MPV were found. In all patients studied, chorioamnionitis (CAM) was significantly associated with MPV (CAM = 10.3 fL vs. no CAM = 9.7 fL, P<0.001). Multivariate analysis showed that SGA, male sex and PIH were associated with PCT and PLT. This study demonstrates that different maternal and neonatal complications affect platelet parameters in late preterm and term neonates.

show abstract

Section: Plos Onesupporting

confidence: 89%

Perinatal factors affecting platelet parameters in late preterm and term neonates

Ohto

Nollet

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…[24] This study showed that MPV was high in newborns born from pregnancies with PROM. Chen et al [25] found that MPV correlates with intrauterine infection in newborns with combined leukopenia and thrombocytopenia. MPV was also associated with the development of intracranial hemorrhage, chronic lung disease and necrotizing enterocolitis in preterm very low birth weight infants.…”

Section: Discussionmentioning

confidence: 99%

Effect of perinatal factors on platelet indices in late preterm and term newborns

Üstün

2021

Journal of Contemporary Medicine

View full text Add to dashboard Cite

This study aimed to compare platelet indices between late preterm and term newborns, and to analyze their relationship with perinatal conditions. Material and Method: Ninety-eight late preterm and 102 term newborns admitted to the neonatal intensive care unit between 2018 and 2020 were retrospectively evaluated. Platelet indices including platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) were measured in blood samples taken on the first day of life. Results: There was no significant difference in the PLT, MPV, PCT, and PDW values between late preterm and term newborns. In late preterm newborns, multivariable analysis showed that maternal hypertension was significantly related to lower PLT (p=0.001). In term newborns, multivariable analysis showed that being small for gestational age (SGA), male sex, and maternal hypertension were significantly related to lower PLT (p<0.001, p=0.001 and p=0.017, respectively). In addition, SGA and male sex were related to lower PCT (p=0.001). In all studied patients, MPV was significantly different between infants with and without prolonged rupture of membrane (PROM) (9.8 fL vs. 9.2 fL, p=0.001). Conclusion:The obtained results show that various perinatal features influence the platelet indices in late preterm and term newborns.

show abstract

“…The stress mechanism experienced in the intrauterine period leads to some hematological disorders in a completely unknown way. This may also manifest itself as thrombocytopenia or leukopenia [4]. Early leukopenia, particularly neutropenia, has been associated with an increased incidence of sepsis.…”

Section: Discussionmentioning

confidence: 99%

Can Hematological Parameters be a Indicator Risk Factor in the Development of Retinopathy of Prematurity?

et al. 2020

View full text Add to dashboard Cite

Background Hematological parameters have been investigated as being indicative of increased inflammatory response in morbidity of very preterm infants. This study aims to determine whether the hematologic parameters and ratios of preterms can be an indicative risk factor for the development of retinopathy of prematurity (ROP). Materials-Methods This retrospective cohort study examined newborns born before 32 weeks. Twenty-three patients treated with the diagnosis of ROP were included in the patient group. The control group included 23 patients who did not have ROP (no-ROP). Medical records of eligible preterm infants were retrospectively reviewed. Hemogram samples obtained from all patients during the first 24 h of life and samples of their mothers obtained before delivery were evaluated. The hemogram parameters of white blood cell (WBC) count, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, lymphocyte/monocyte ratio, and platelet mass index were calculated. Results No difference was observed between the groups in terms of demographic data. In terms of hematological parameters, maternal WBC counts of ROP patients were significantly higher than those of no-ROP patients and WBC counts of ROP patients were significantly lower than those of no-ROP patients. Conclusions This study found that high WBC counts in mothers before delivery and/or low WBC counts in preterms during the first postnatal day were higher in developed ROP. These results could lead to the development of prospective studies to assess the real prognostic value of WBC in ROP.

show abstract

Use of mean platelet volume in the assessment of intrauterine infection in newborns with combined thrombocytopenia and leukopenia at birth

Cited by 4 publications

References 17 publications

Perinatal factors affecting platelet parameters in late preterm and term neonates

Perinatal factors affecting platelet parameters in late preterm and term neonates

Effect of perinatal factors on platelet indices in late preterm and term newborns

Can Hematological Parameters be a Indicator Risk Factor in the Development of Retinopathy of Prematurity?

Contact Info

Product

Resources

About