Use of magnetic resonance imaging combined with gene analysis for the diagnosis of fetal congenital heart disease

Wang, Lishun; Nie, Hanxiang; Wang, Qichen; Zhang, Guoliang; Li, Gang; Bai, Liwei; Hua, Tianshu; Wei, Shuzhang

doi:10.1186/s12880-019-0314-8

Cited by 11 publications

(2 citation statements)

References 35 publications

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“…A recent research study showed that magnetic resonance imaging, in combination with gene analysis using array comparative genome hybridization analysis and fluorescence in situ hybridization could be a more effective diagnostic method for CDHs [ 149 ]. Similarly, molecular biomarkers too have shown considerable promise for use in prenatal diagnosis of CHD [ 150 , 151 , 152 ].…”

Section: Diagnosis Of Chdmentioning

confidence: 99%

Insights into Cardiovascular Defects and Cardiac Epigenome in the Context of COVID-19

Sarkar

Sen

2022

Epigenomes

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Although few in number, studies on epigenome of the heart of COVID-19 patients show that epigenetic signatures such as DNA methylation are significantly altered, leading to changes in expression of several genes. It contributes to pathogenic cardiac phenotypes of COVID-19, e.g., low heart rate, myocardial edema, and myofibrillar disarray. DNA methylation studies reveal changes which likely contribute to cardiac disease through unknown mechanisms. The incidence of severe COVID-19 disease, including hospitalization, requiring respiratory support, morbidity, and mortality, is disproportionately higher in individuals with co-morbidities. This poses unprecedented strains on the global healthcare system. While their underlying conditions make patients more susceptible to severe COVID-19 disease, strained healthcare systems, lack of adequate support, or sedentary lifestyles from ongoing lockdowns have proved detrimental to their underlying health conditions, thus pushing them to severe risk of congenital heart disease (CHD) itself. Prophylactic vaccines against COVID-19 have ushered new hope for CHD. A common connection between COVID-19 and CHD is SARS-CoV-2’s host receptor ACE2, because ACE2 regulates and protects organs, including the heart, in various ways. ACE2 is a common therapeutic target against cardiovascular disease and COVID-19 which damages organs. Hence, this review explores the above regarding CHDs, cardiovascular damage, and cardiac epigenetics, in COVID-19 patients.

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Section: Diagnosis Of Chdmentioning

confidence: 99%

Insights into Cardiovascular Defects and Cardiac Epigenome in the Context of COVID-19

Sarkar

Sen

2022

Epigenomes

View full text Add to dashboard Cite

show abstract

“…The magnetic resonance imaging (MRI) is considered one of the noninvasive imaging methods in radiology for diagnosis to detect the soft organs size, shape and homogeneity [9]. MRI safety and quality of imaging was confirmed in diagnosis of the pediatric and adult patients with congenital heart disease [10], and oncology diagnosis [11] in different types of cancer: for examples, breast cancer [12], cervical cancer [13], lung cancer [14] and prostate cancer [15]. Using MRI during the experimental trial on animal models supports the researchers with all data about localization or metastasis of cancer whether about the solid or ascites tumor.…”

Section: Introductionmentioning

confidence: 99%

Anti-Tumor Effect of Green Tea Extract, Simvastatin and Gamma Radiation on Solid Tumor in Mice

Abdelrahman

El‐Kashef

Hassan

2020

Arab Journal of Nuclear Sciences and Applications

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The current study was conducted of six groups (n=12) to define the efficacy of epigallocatechin gallate, simvastatin and gamma radiation individually or combined together to reduce solid tumor size induced by intramuscular injection of EC cells in the right thigh of the targeted mice. Magnetic resonance imaging device)1.5 Tesla(used for radiology imaging of the normal and ascites-bearing mice under anesthesia. The animals with solid tumors were followed up daily for recording deaths, tumor size, rate of inflammation and gangrene in the tumor area of hind limb. Magnetic resonance imaging showed the intraperitoneal ascites and the soft organs (liver, kidney and intestine) which were bright in the case of ascites-bearing mouse than the normal control. Triple therapy regimen significantly reduced the tumor size (662.6±12.5) compared to the positive control (825±21.8) and increased survival rate to 66.7% compared to 25% in the positive control. Triple therapy reduced the inflammation of tumor area, preventing the gangrene incidence, and showed the best value of T/C=142, ILS=42.11 and TIR %=19.6 compared to the positive control and single treatments, hence, it is considered an anti-tumor regimen according to the National Cancer Institute criteria.

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DPC-MSGATNet: dual-path chain multi-scale gated axial-transformer network for four-chamber view segmentation in fetal echocardiography

Qiao

Pang

Luo

et al. 2023

Complex Intell. Syst.

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Echocardiography is essential in evaluating fetal cardiac anatomical structures and functions when clinicians conduct early treatment and screening for congenital heart defects, a common and intricate fetal malformation. Nevertheless, the prenatal detection rate of fetal CHD remains low since the peculiarities of fetal cardiac structures and the variousness of fetal CHD. Precisely segmenting four cardiac chambers can assist clinicians in analyzing cardiac morphology and further facilitate CHD diagnosis. Hence, we design a dual-path chain multi-scale gated axial-transformer network (DPC-MSGATNet) that simultaneously models global dependencies and local visual cues for fetal ultrasound (US) four-chamber (FC) views and further accurately segments four chambers. Our DPC-MSGATNet includes a global and a local branch that simultaneously operates on an entire FC view and image patches to learn multi-scale representations. We design a plug-and-play module, Interactive dual-path chain gated axial-transformer (IDPCGAT), to enhance the interactions between global and local branches. In IDPCGAT, the multi-scale representations from the two branches can complement each other, capturing the same region’s salient features and suppressing feature responses to maintain only the activations associated with specific targets. Extensive experiments demonstrate that the DPC-MSGATNet exceeds seven state-of-the-art convolution- and transformer-based methods by a large margin in terms of F1 and IoU scores on our fetal FC view dataset, achieving a F1 score of 96.87$$\%$$ % and an IoU score of 93.99$$\%$$ % . The codes and datasets can be available at https://github.comQiaoSiBo/DPC-MSGATNet.

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Use of magnetic resonance imaging combined with gene analysis for the diagnosis of fetal congenital heart disease

Cited by 11 publications

References 35 publications

Insights into Cardiovascular Defects and Cardiac Epigenome in the Context of COVID-19

Insights into Cardiovascular Defects and Cardiac Epigenome in the Context of COVID-19

Anti-Tumor Effect of Green Tea Extract, Simvastatin and Gamma Radiation on Solid Tumor in Mice

DPC-MSGATNet: dual-path chain multi-scale gated axial-transformer network for four-chamber view segmentation in fetal echocardiography

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