Anti-Tumor Effect of Green Tea Extract, Simvastatin and Gamma Radiation on Solid Tumor in Mice

Abdelrahman, Ibrahim Y.; El‐Kashef, Hussein; Hassan, Neveen A.

doi:10.21608/ajnsa.2020.22827.1322

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…At the completion of the experiment, the rats were humanely euthanized by giving thiopental sodium (50 mg/kg) intraperitoneally ( Abdelrahman et al, 2020 ). At 24 h after dosing of saline or WP, the samples were collected at two time intervals (on days 7 and 14).…”

Section: Methodsmentioning

confidence: 99%

Radioprotective potential of whey protein against gamma irradiation-induced lingual damage

Hassan,

Abdeen,

Abdelrahman

et al. 2023

Front. Pharmacol.

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Introduction: Ionizing radiation (IR) is effectively used in the treatment of oral malignancies; however, it might also significantly harm the surrounding tissues. Whey protein isolate (WP) is a protein derived from milk that exhibits a wide range of bioactivities. Therefore, the present research aimed to delineate the mitigating impact of WP against gamma irradiation-induced lingual damage.Methods: Rats were randomized into 5 groups: Control (saline, orally, 14 days), WP (WP; 0.5 g/kg b. w., orally, 14 days), IR (saline, orally, 14 days, exposed to 6 and 3 Gy on days 4 and 6, respectively), WP+IR (WP was given orally for 14 days before and after IR exposure; exposed to 6 and 3 Gy on days 4 and 6, respectively), and IR+WP (WP, orally, started 24 h after 1st IR exposure till the end of the experiment) groups. Samples were collected at two-time intervals (on the 7th and 14th days).Results and Discussion: Oxidative stress was stimulated upon IR exposure in tongue, indicated by boosted malondialdehyde (MDA) level, along with a decrease in the total antioxidant capacity (TAC) level, superoxide dismutase (SOD), and catalase (CAT) activities. Additionally, IR exposure depicted an increase of serum IgE, inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin (IL)-6, along with overexpression mRNA levels of nuclear factor kappa-B transcription factor/p65 (NF-κB/p65), and down-regulation of nuclear factor erythroid 2–related factor 2 (NRF2) and heme oxygenase (HO-1) mRNA levels in tongue tissue. Moreover, IR triggered alterations in lingual histological architecture. The antioxidant and anti-inflammatory properties of WP mitigated oxidative damage, inflammation, and desquamation that were brought on following IR exposure. The protective administration of WP markedly decreases IR-induced lingual harm compared to the mitigation protocol. Our findings recommend WP supplements to the diets of cancer patients undergoing IR that might aid radioprotective effects.

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Section: Methodsmentioning

confidence: 99%

Radioprotective potential of whey protein against gamma irradiation-induced lingual damage

Hassan,

Abdeen,

Abdelrahman

et al. 2023

Front. Pharmacol.

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Assessment of sweet whey fortified with selenium and Bifidobacteria on reduction of pesticide liver toxicity in albino rats

Moawad,

Osman,

Hassanein

et al. 2024

Preprint

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Background Deltamethrin (DLM) represents one of the most commonly used pesticides. DLM passes through milk, vegetables, and fruits to humans or through animals (veterinary drugs and feeding on contaminated forage) to milk; it can escape from skin to blood and be secreted in breast milk in lactating women. It was believed to have neurotoxic, nephrotoxic, and hepatotoxic properties. Methods In order to investigate deltamethrin-induced hepatotoxicity, 64 rats were divided into 8 groups. The control group did not receive any treatment. D 30 mg/kg DLM (body weight) dissolved in corn oil, B 1 mL whey (1010 cfu/ml of Bifidobacterium logum ATCC 15707), S 1 mL whey (0.5 ppm selenium), BS 1 mL whey (1010 cfu/mL of Bifidobacterium logum ATCC 15707 + 0.5 ppm selenium), BD 1 mL whey (1010 cfu/mL of Bifidobacterium logum ATCC 15707 + DLM), SD 1 mL whey (0.5 ppm selenium) + DLM, and BSD 1 mL whey (1010 cfu/mL of Bifidobacterium logum ATCC 15707) + 0.5 ppm selenium + DLM. Results Results marked that manipulation of bifidobacteria, or selenium triggered significant improvement in AST, ALT, GSH, TNF-α, NF-KB and BCL2 as well as reduction in histopathological necrosis, congestion, and degradation. Conclusion Whey beverage fortified with Bifidobacterium longum and selenium implicated reduction in oxidative stress, histopathological degradation that accomplished DLM toxicity. Utilization of whey (a byproduct from cheese making) is considered a recycling process which supports ecofriendly practices and sustainability.

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Anti-Tumor Effect of Green Tea Extract, Simvastatin and Gamma Radiation on Solid Tumor in Mice

Cited by 2 publications

References 23 publications

Radioprotective potential of whey protein against gamma irradiation-induced lingual damage

Radioprotective potential of whey protein against gamma irradiation-induced lingual damage

Assessment of sweet whey fortified with selenium and Bifidobacteria on reduction of pesticide liver toxicity in albino rats

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