Use of Low Molecular Weight Heparin and Aminocaproic Acid in Chronic DIC Associated with Prostate Cancer- A Case Report

Shirai, Keisuke; Chaudhary, Uma

doi:10.1100/tsw.2007.143

Cited by 6 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some authors have claimed improvement using unfractionated or low-molecular-weight heparin [27,28]. Others have achieved some success with the fibrinolytic inhibitor aminocaproic acid, either alone or in combination with low-molecular-weight heparin [29,30]. …”

Section: Discussionmentioning

confidence: 99%

Disseminated Intravascular Coagulation with Excessive Fibrinolysis in Prostate Cancer: A Case Series and Review of the Literature

2011

View full text Add to dashboard Cite

Objectives: To describe the clinical characteristics, diagnostic features, prognosis, and outcome of patients with prostate cancer and disseminated intravascular coagulation with excessive fibrinolysis (DIC XFL). Methods: We performed a retrospective analysis of prostate cancer patients seen at a single center from March 21, 2000, to July 31, 2006, with a fibrinogen level <150 mg/dl and two of the following criteria: platelets <150 × 10⁹/l, D-dimer >0.5 µg/ml, prothrombin time and activated partial thromboplastin time exceeding normal values, hemorrhage and/or thrombosis. Patients with comorbid conditions that cause coagulopathy were excluded. Results: Forty-two patients met the inclusion criteria. Most patients had high-grade prostate cancer (26% had Gleason 7 and 45% had Gleason 8–10). Three patients developed DIC XFL following surgery and 39 patients in the setting of metastatic disease; 93% were resistant to castration, and 50% had received prior taxanes. No deep-vein thromboses were documented. Management included blood transfusion, heparin, hormones, and chemotherapy. Median survival was 4 weeks. DIC XFL reversal was seen in 20% of metastatic patients, all of whom received new chemotherapy regimens. Median survival in this group was 26 weeks. Conclusions: DIC XFL is a rare complication of prostate cancer. Untreated, the risk of hemorrhage is high and the prognosis poor. Reversal of DIC XFL appears to correlate with response to new anticancer therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Disseminated Intravascular Coagulation with Excessive Fibrinolysis in Prostate Cancer: A Case Series and Review of the Literature

2011

View full text Add to dashboard Cite

show abstract

“…The pathophysiology of disseminated intravascular coagulopathy in patients with prostate cancer is not completely understood. Investigators reported coagulation disorders as early or late signs in PCA (Bern, 2005;Navarro et al, 2006;Duran and Tannock, 2007;Shirai and Chaudhary, 2007). We found highly up-regulated F8, F5, F9, VWF, and F3 gene accumulation around ca-dependent and ca-phospholipid dependent regions of the coagulation pathway.…”

Section: Discussionmentioning

confidence: 53%

Gene network and canonical pathway analysis in prostate cancer: a microarray study

et al. 2008

View full text Add to dashboard Cite

The molecular mechanism playing a role in the development of prostate cancer (PCA) is not well defined. We decided to determine the changes in gene expression in PCA tissues and to compare them to those in noncancerous samples. Prostate tissue samples were collected by needle biopsy from 21 PCA and 10 benign prostate hyperplasic (BPH) patients. Total RNA was isolated, cDNA was synthesized, and gene expression levels were determined by microarray method. In the progression to PCA, 738 up-regulated and 515 downregulated genes were detected in samples. Analysis using Ingenuity Pathway Analysis (IPA) software revealed that 466 network and 423 functions-pathways eligible genes were up-regulated, and 363 network and 342 functions-pathways eligible genes were down-regulated. Up-regulated networks were identified around IL-1β and insulin-like growth factor-1 (IGF-1) genes. The NFKB gene was centered around two upand down-regulated networks. Up-regulated canonical pathways were assigned and four of them were evaluated in detail: acute phase response, hepatic fibrosis, actin cytoskeleton, and coagulation pathways.Axonal guidance signaling was the most significant down-regulated canonical pathway. Our data provide not only networks between the genes for understanding the biologic properties of PCA but also useful pathway maps for future understanding of disease and the construction of new therapeutic targets.

show abstract

Disseminated Intravascular Coagulation (DIC) in Cancer

Saba

Morelli

Saba

2009

Cancer Treatment and Research

View full text Add to dashboard Cite

Use of Low Molecular Weight Heparin and Aminocaproic Acid in Chronic DIC Associated with Prostate Cancer- A Case Report

Cited by 6 publications

References 13 publications

Disseminated Intravascular Coagulation with Excessive Fibrinolysis in Prostate Cancer: A Case Series and Review of the Literature

Disseminated Intravascular Coagulation with Excessive Fibrinolysis in Prostate Cancer: A Case Series and Review of the Literature

Gene network and canonical pathway analysis in prostate cancer: a microarray study

Disseminated Intravascular Coagulation (DIC) in Cancer

Contact Info

Product

Resources

About