Use of Intravenous Fat Emulsions in Surgical Patients

Effects in Dogs of two Fat Emulsions for Intravenous Nutrition

“…Although acute toxic effects have been practically lacking in the fat emulsions available commercially, a number of delayed reactions have been reported after multiple infusions (9)(10)(11)(12)(13)(14)(15)(16). These reactions have, to some extent, limited the use of such emulsions in patients requiring lengthy parenteral nutrition.…”

The Theoretical Background of the Intravenous Nutrition with Fat Emulsions

“…The secretion seems to be abolished after denervation of the stom ach. Vomiting and nausea have been reported w ith cottonseed oil em ulsions both in man (70,83) and anim als (17). Cottonseed oil emulsions will always cause vom iting in dogs if the dose is large enough (17).…”

“…In m an and in dogs prolonged coagulation tim e, prothrom bin tim e and trom bocytopenia have been observed (3,17,71,94) and spontaneous bleedings m ay also occur (3,17). In our dog experim ents wre can invariably cause severe lethal bleedings in dogs after 4 to 5 days with a high cottonseed oil emulsion dose.…”

“…W ith cottonseed oil em ulsion one has observed abnorm al B SP -retention, increased th y m o l tu rb id ity and cephalin flocculation (70,93). This m ay be seen in m an when 1-2 g fat/kg is given for 11-20 days.…”

“…This condition is characterized by fever, headache, hyperirritability, nausea, ab dom inal pain, lethargy, anorexia (70,93). One has also registered liepato-an d splenom egaly together w ith icterus (4,64,93) and gastro in testinal bleedings, prolonged coagulation tim e and anaem ia.…”