Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease

Sumpio, Brandon J.; Citoni, Gianluca; Chin, Jason A.; Sumpio, Bauer E.

doi:10.1016/j.jvs.2016.03.463

Cited by 18 publications

(13 citation statements)

References 38 publications

(56 reference statements)

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“…The clinical use of this technique has been previously investigated in patients with cervical cancer and skin cancer as well as in an application for lower extremity perfusion measurements [11]. Previous studies determined superficial tissue oxygenation with HSI in patients with PAOD and diabetes mellitus (DM) and showed an association with severity of disease and wound healing [12][13][14][15]. Chin et al showed that lower values of DeoxyHb were associated with peripheral arterial disease, and that DeoxyHb values correlated with ABI [16].…”

Section: Introductionmentioning

confidence: 99%

Reliability assessment of hyperspectral imaging with the HyperView™ system for lower extremity superficial tissue oxygenation in young healthy volunteers

Kleiss

Kirsten

Moumni

et al. 2021

J Clin Monit Comput

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Purpose: Hyperspectral imaging (HSI) is a noninvasive spectroscopy technique for determining superficial tissue oxygenation. The HyperView™ system is a hand-held camera that enables perfusion image acquisition. The evaluation of superficial tissue oxygenation is warranted in the evaluation of patients with peripheral arterial disease. The aim was to determine the reliability of repeated HSI measurements. Methods: In this prospective cohort study, HSI was performed on 50 healthy volunteers with a mean age of 26.4 ± 2.5 years, at the lower extremity. Two independent observers performed HSI during two subsequent measurement sessions. Short term test–retest reliability and intra- and inter-observer reliability were determined, and generalizability and decision studies were performed. Transcutaneous oxygen pressure (TcPo2) measurements were also performed. Results: The short term test–retest reliability was good for the HSI values determined at the lower extremity, ranging from 0.72 to 0.90. Intra- and inter-observer reliability determined at different days were poor to moderate for both HSI (0.24 to 0.71 and 0.30 to 0.58, respectively) and TcPo2 (0.54 and 0.56, and 0.51 and 0.31, respectively). Reliability can be increased to >0.75 by averaging two measurements on different days. Conclusion: This study showed good short term test–retest reliability for HSI measurements, however low intra- and inter-observer reliability was observed for tissue oxygenation measurements with both HSI and TcPo2 performed at separate days in young healthy volunteers. Reliability of HSI can be improved when determined as a mean of two measurements taken on different days.

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Section: Introductionmentioning

confidence: 99%

Reliability assessment of hyperspectral imaging with the HyperView™ system for lower extremity superficial tissue oxygenation in young healthy volunteers

Kleiss

Kirsten

Moumni

et al. 2021

J Clin Monit Comput

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“…5 The HTCOM device has been used to evaluate endothelial function in vascular patients in a recent publication by Sumpio et al, which demonstrated the ability of this technology to potentially assess and screen for the presence of PVD. 6 The OxyVu (HyperMed Inc, Burlington, Mass) is a mobile HTCOM system that noninvasively obtains information from the subpapillary plexus by detecting the presence of chromophores that are uniquely specific to oxyhemoglobin (HT-Oxy) and deoxyhemoglobin (HT-Deoxy). 7 Using a "target," that is, a small sticker that measures a standard surface area of 204 mm 2 placed at the region of interest, the mounted camera produces light at various wavelengths that penetrates the skin to a depth of 1 to 2 mm.…”

mentioning

confidence: 99%

Evaluation of hyperspectral imaging technology in patients with peripheral vascular disease

Chiang

Jain

Sleigh

et al. 2017

Journal of Vascular Surgery

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“…This study had a unique design and unique findings compared to previous studies that used SWIR light HSI as a clinical diagnostic technique [17,46,48]. Our study used the HSI technique to identify early-stage disease with invisible skin changes.…”

Section: Discussionmentioning

confidence: 99%

Assessment of diabetic small‐fiber neuropathy by using short‐wave infrared hyperspectral imaging

Sheen

Sheu

Wang

et al. 2021

Journal of Biophotonics

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Among patients with type 2 diabetes mellitus (T2DM), the association between hyperspectral imaging (HSI) examination and diabetic neuropathy (DN) is ascertained using HSI of the feet using four types of spectral difference measurements. DN was evaluated by traditional Michigan Neuropathy Screening Instrument (MNSI), evaluation of painful neuropathy (ID-Pain, DN4) and sudomotor function by measuring electrochemical skin conductance (ESC). Of the 120 T2DM patients and 20 healthy adults enrolled, T2DM patients are categorized into normal sudomotor (ESC >60 μS)and sudomotor dysfunction (ESC ≤ 60 μS) groups. Spectral difference analyses reveal significant intergroup differences, whereas traditional examinations cannot distinguish between the two groups. HSI waveform reflectance gradually increases with disease severity, at 1400 to 1600 nm. The area under the curve (AUC) of receiver operating characteristic (ROC) analysis for abnormal ESC is ≥0.8 for all four HSI methods. HSI could be an objective, sensitive, rapid, noninvasive and remote approach to identify early small-fiber DN.diabetic neuropathy (DN), electrochemical skin conductance (ESC), hyperspectral imaging (HSI), short-wave infrared (SWIR), type 2 diabetes mellitus (T2DM)

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Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease

Cited by 18 publications

References 38 publications

Reliability assessment of hyperspectral imaging with the HyperView™ system for lower extremity superficial tissue oxygenation in young healthy volunteers

Reliability assessment of hyperspectral imaging with the HyperView™ system for lower extremity superficial tissue oxygenation in young healthy volunteers

Evaluation of hyperspectral imaging technology in patients with peripheral vascular disease

Assessment of diabetic small‐fiber neuropathy by using short‐wave infrared hyperspectral imaging

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