Assessment of diabetic small‐fiber neuropathy by using short‐wave infrared hyperspectral imaging

Abstract

Among patients with type 2 diabetes mellitus (T2DM), the association between hyperspectral imaging (HSI) examination and diabetic neuropathy (DN) is ascertained using HSI of the feet using four types of spectral difference measurements. DN was evaluated by traditional Michigan Neuropathy Screening Instrument (MNSI), evaluation of painful neuropathy (ID-Pain, DN4) and sudomotor function by measuring electrochemical skin conductance (ESC). Of the 120 T2DM patients and 20 healthy adults enrolled, T2DM patients are categorized into normal sudomotor (ESC >60 μS)and sudomotor dysfunction (ESC ≤ 60 μS) groups. Spectral difference analyses reveal significant intergroup differences, whereas traditional examinations cannot distinguish between the two groups. HSI waveform reflectance gradually increases with disease severity, at 1400 to 1600 nm. The area under the curve (AUC) of receiver operating characteristic (ROC) analysis for abnormal ESC is ≥0.8 for all four HSI methods. HSI could be an objective, sensitive, rapid, noninvasive and remote approach to identify early small-fiber DN.diabetic neuropathy (DN), electrochemical skin conductance (ESC), hyperspectral imaging (HSI), short-wave infrared (SWIR), type 2 diabetes mellitus (T2DM)

Estudio y manejo de las neuropatías de fibra fina

“…La evolución hacia una cardioneuropatía diabética o una neuropatía con úlceras tórpidas y artropatía son dos de los ejemplos de mala evolución de esta enfermedad. El uso de nuevas técnicas de imagen, como la termografía cutánea o el análisis espectral combinado con estudios de electroconductancia cutánea para cuantificar la sudoración, ayudan a una detección precoz del problema 44 . La microscopia confocal corneal con análisis del plexo subbasal permite una monitorización in vivo de la neuropatía 45 .…”