Use of hyperdry amniotic membrane in operations for cleft palate: a study in rats

Tsuno, Hiroaki; Noguchi, Makoto; Okabe, Motonori; Tomihara, Kei; Yoshida, Toshiko; Nikaido, Toshio

doi:10.1016/j.bjoms.2015.01.018

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…We have previously reported problem-free use of hyperdry amnion as a wound-covering material after tumor resection in the oral region. 13,14 We have also reported that in animal experiments, covering exposed areas of maxillary bone with hyperdry amnion has a little adverse effect on the bone or dentition. 4 In this present study, we successfully used the HDAM for palatoplasty without any problems, as in the aforementioned previous studies.…”

Section: Discussionmentioning

confidence: 89%

“…With regard to using in cases involving bone, we have previously reported cases in which intraoral alveolar wounds with bone exposure were successfully treated via HDAM. 14 On the other hand, we have also suggested that HDAM may be a suitable new dressing material for use in the treatment of cleft palate based on an experimental study in rats. 4 In Japan, artificial materials including atelocollagen of bovine origin have been widely used to achieve better re-epithelialization following pushback palatoplasty.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Application of Hyperdry Amniotic Membrane in Cleft Palate Repair

Fujiwara

Tsuno

Okabe

et al. 2022

The Cleft Palate Craniofacial Journal

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Objective To examine the safety and efficacy of hyperdry amniotic membrane (HDAM) for wound closure after palatoplasty in cleft palate patients. Methods HDAMs were prepared by washing and drying under infrared rays and microwaves at temperatures less than 60°C using a hyperdrying device. A total of 16 cleft palate patients (8 males, 8 females), aged 1 to 3 years (mean age 1 year 9 months), received one-stage pushback palatoplasty. The remaining raw wound after surgery was covered by an HDAM and a plastic cover plate. The cover plate was removed 1 week after surgery and parameters including temperature, feeding, allergic reactions, postoperative bleeding, re-epithelialization, wound dehiscence, and infection were monitored during the follow-up period of 31.2 months. Results All patients could adequately ingest at 5 days postoperation and after removal of the cover plate. None of the patients had a persistent fever or allergic reactions. Ingestion was feasible immediately in all patients, and no postoperative bleeding was observed during ingestion. No secondary hemorrhages were observed during follow-up. No postoperative wound dehiscence on the midline of the palate was observed. No infections were observed after the removal of the cover plate. No patients suffered from severe scar formation or contracture of the wound in the follow-up period. Hemorrhage, undue epithelialization, and scar contracture did not occur in any patient. The mean evaluation score was 7.75 points. Conclusion HDAM can be used safely and effectively for wound closure following palatoplasty in cleft palate infants. Future studies testing the safety of patient's own amnion for palatoplasty, are required.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Clinical Application of Hyperdry Amniotic Membrane in Cleft Palate Repair

Fujiwara

Tsuno

Okabe

et al. 2022

The Cleft Palate Craniofacial Journal

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“…This study also suggested that there might be some preventive effect against postoperative scar formation associated with the use of HD‐AM on oral wounds. We have previously reported that HD‐AM reduced the inhibition of lateral palatal growth in a cleft palate rat model . It has been reported that palatal scarring is the primary cause of growth disturbances because scar tissue develops over the denuded palatal bone that remains after palatoplasty .…”

Section: Discussionmentioning

confidence: 98%

Clinical application and evaluation of hyperdried human amniotic membrane for the surgical repair of oral mucosal defects

Tsuno

Okabe

Fujiwara

et al. 2019

Oral Science International

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The amniotic membrane is highly biocompatible, possesses anti‐inflammatory properties, and has been used for reconstructive surgeries in various areas. However, there have been persistent problems related to its preparation, storage, and sterilization. Hyperdried human amniotic membrane (HD‐AM) was developed at the Toyama University to resolve these problems of fresh amnion. The aim of this study was to evaluate the clinical effects of the surgical repair of oral mucosal defects by using HD‐AM. In total, 29 patients with oral precancerous lesions or early‐stage cancer were included. After resection of the oral lesions, surgical defects of the oral mucosa were covered with HD‐AM in 15 patients (HD‐AM group) and with commercial collagen graft material in 14 patients (CGM group). Postoperative pain, feeding state, epithelialization, the scarring of the wound, and oral function were evaluated. The postoperative medication period of nonsteroidal anti‐inflammatory drug use was significantly shorter (P = 0.0457) and the recovery period for resumption of oral feeding was also significantly earlier (P = 0.0414) in the HD‐AM group than in the CGM group, without specific complications. HD‐AM reduced the postoperative inflammation; it can be used as a novel dressing material for the surgical repair of oral mucosal defects.

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“…The issue of treating cleft palate with amniotic membranes was raised in 2015 by Tsuno et al in a study on rats. Their results suggest that the hyper-dry amniotic membrane (HDAM) is a suitable new dressing material for use in the treatment of cleft palate [41]. In 2023, Fujiwara et al published an article on the same issue, but this time, the study population included 16 patients with a mean age of one year and nine months.…”

Section: Cleft Palatementioning

confidence: 99%

Introduction to Amniotic Membranes in Maxillofacial Surgery—A Scoping Review

Dawiec,

Niemczyk,

Wiench

et al. 2024

Medicina

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Background: Amniotic membrane (AM) holds significant promise in various medical fields due to its unique properties and minimal ethical concerns. This study aims to explore the diverse applications of the human amniotic membrane (HAM) in maxillofacial surgery. Methodology: A comprehensive search was conducted on databases, namely Google Scholar, PubMed, and Scopus, from January 1985 to March 2024. Articles in English, Polish, and Spanish were included, focusing on keywords related to amniotic membrane and oral surgery. Results: Various preservation methods for HAM were identified, namely fresh, decellularized, cryopreserved, lyophilized, and air-dried formats. Clinical studies demonstrated the efficacy of HAM in repairing oral mucosal defects, vestibuloplasty, oronasal fistula closure, cleft palate treatment, bone defect repair, and medication-related osteonecrosis of the jaw (MRONJ). Surgeon evaluations highlighted the ease of handling but noted challenges in suturing and stability during application. Conclusions: Amniotic membranes offer a versatile and effective option in maxillofacial surgery, promoting wound healing, reducing inflammation, and providing a scaffold for tissue regeneration. Further research, including randomized trials and comparative studies, is warranted to validate the efficacy and optimize the utilization of HAM in clinical practice.

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Use of hyperdry amniotic membrane in operations for cleft palate: a study in rats

Cited by 7 publications

References 25 publications

Clinical Application of Hyperdry Amniotic Membrane in Cleft Palate Repair

Clinical Application of Hyperdry Amniotic Membrane in Cleft Palate Repair

Clinical application and evaluation of hyperdried human amniotic membrane for the surgical repair of oral mucosal defects

Introduction to Amniotic Membranes in Maxillofacial Surgery—A Scoping Review

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