Use of Hydroxypropyl Methylcellulose Acetate Succinate in an Enteric Polymer Matrix To Design Controlled-Release Tablets of Amoxicillin Trihydrate

Hilton, Alan K.; Deasy, P. B.

doi:10.1002/jps.2600820713

Cited by 21 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several different types of hypromellose phthalate (HP50, HP55, HP55S) are commercially available with molecular weights in the range 20,000-200,000 (16). Both HPMCAS and HPMCP are widely used in oral pharmaceutical formulations as an enteric coating polymer for tablets or granules or pellets formulation (17,18). They may be used alone or in combination with other soluble or insoluble binders in the preparation of granules/pellets with sustained drug release properties (19,20).…”

Section: Introductionmentioning

confidence: 99%

Interpolyelectrolyte Complexes of Eudragit® EPO with Hypromellose Acetate Succinate and Eudragit® EPO with Hypromellose Phthalate as Potential Carriers for Oral Controlled Drug Delivery

Jeganathan

Prakya²

2015

AAPS PharmSciTech

View full text Add to dashboard Cite

The objective of this study was to compare a novel controlled release tablet formulation based on interpolyelectrolyte complex (PEC). Interpolymer interactions between the countercharged polymers like Eudragit® EPO (polycation) and hypromellose acetate succinate (polyanion) and Eudragit® EPO and hypromellose phthalate (polyanion) were investigated with a view to their use in per oral controlled release drug delivery systems. The formation of inter-macromolecular ionic bonds between cationic polymer and anionic polymer was investigated using Fourier transform infrared (FT-IR) spectroscopy and differential scanning calorimetry. The FT-IR spectra of the tested polymeric matrices are characterized by visible changes in the observed IR region indicating the interaction between chains of two oppositely charged copolymers. The performance of the in situ formed PEC as a matrix for controlled release of drugs was evaluated, using acetaminophen as a model drug. The dissolution data of these matrices were fitted to different dissolution models. It was found that drug release followed zero-order kinetics and was controlled by the superposition of the diffusion and erosion. These profiles could be controlled by conveniently modifying the proportion of the polymer ratio, polymer type, and polymer concentration the in the tablets.

show abstract

Section: Introductionmentioning

confidence: 99%

Interpolyelectrolyte Complexes of Eudragit® EPO with Hypromellose Acetate Succinate and Eudragit® EPO with Hypromellose Phthalate as Potential Carriers for Oral Controlled Drug Delivery

Jeganathan

Prakya²

2015

AAPS PharmSciTech

View full text Add to dashboard Cite

show abstract

“…The solution was cooled to room temperature and allowed to evaporate solvent completely. Formed Crystals were dried under vacuum at room temperature and stored in a desiccator for further use 14 .…”

Section: Solubility Enhancement Of Accmentioning

confidence: 99%

Enhancement of Antimicrobial Activity of Suppress Release Amoxicillin Camphor Complexed Mucoadhesive Tablets by Statistical Experimental Design

Barghav¹,

Bhargav²,

Bhargav³

et al. 2019

Int Res J Pharm

View full text Add to dashboard Cite

Objective: The purpose of the present work was to enhance antimicrobial activity of Suppress release Amoxicillin Camphor complexed Mucoadhesive tablets by Statistical Experimental Design using Sigma tech software version 3.1. Amoxicillin has short half-life (1 h) which requires frequent administration of the conventional amoxicillin tablets and is mainly used in the eradication of Helicobacter pylori that resides in the stomach. Methods: Amoxicillin-Sodium cholate (ASC) and camphor complexes (ACC) were prepared to enhance antimicrobial activity. Results: TLC and FT-IR studies confirmed the formation of drug complex. Zone of inhibition by agar well diffusion method of ACC showed greater inhibition than ASC, solubility of ACC was enhanced by re-crystallization technique. Hence ACC needle shaped re-crystallized was used to sustained release tablets using mucoadhesive polymers. Chitosan, HPMC K-15 and Ethyl cellulose (EC) were selected as independent variables and ex vivo mucoadhesion time, % drug release at 24 h and t 50 % (time to release 50 % drug) were selected as dependent variables. DSC studies indicated drug and excipients were compatible. Swelling studies and scanning electron microscopic analysis confirmed the drug release mechanism from sustained release tablets. In-vitro release studies and ex vivo studies of amoxicillin confirmed the sustained drug release profile with first order release kinetics better mucoadhesion and enhanced antimicrobial activity. The optimized formulation was found to be stable at accelerated storage conditions for 3 months. Conclusion: The results demonstrated the effectiveness of the proposed statistical design for optimization of ACC sustained release tablets.

show abstract

“…Several attempts have been made to develop sustained-release penicillin products, such as penicillin-containing fatty-matrix tablets, 4,5 gelatin microcapsules, 6 enteric polymer matrices 7,8 and so on; but most products do not provide effective sustained release of the drug. 9 At present, the encapsulation of penicillin in an inorganic host and the use of such encapsulation composites as sustained-release medications have not been addressed. In this paper, we describe the intercalation of phenoxymethylpenicillin (PMP), which is a member of the penicillin family, 10 between layers of hydrotalcite (HT).…”

Section: Introductionmentioning

confidence: 99%

Phenoxymethylpenicillin–intercalated hydrotalcite as a bacteria inhibitor

Chen

et al. 2005

J of Chemical Tech & Biotech

View full text Add to dashboard Cite

Phenoxymethylpenicillin (PMP) has been reversibly intercalated into a layered double hydroxide, and the resulting composite exhibits effective anti-bacterial activity. Powder X-ray diffraction studies indicate that the PMP molecules are interdigitated between the inorganic layers, and under mild acidic media, the molecules are released gradually. Therefore a sustained-release anti-bacterial medication is envisioned on the basis of this inorganic-drug composite.

show abstract

Use of Hydroxypropyl Methylcellulose Acetate Succinate in an Enteric Polymer Matrix To Design Controlled-Release Tablets of Amoxicillin Trihydrate

Cited by 21 publications

References 22 publications

Interpolyelectrolyte Complexes of Eudragit® EPO with Hypromellose Acetate Succinate and Eudragit® EPO with Hypromellose Phthalate as Potential Carriers for Oral Controlled Drug Delivery

Interpolyelectrolyte Complexes of Eudragit® EPO with Hypromellose Acetate Succinate and Eudragit® EPO with Hypromellose Phthalate as Potential Carriers for Oral Controlled Drug Delivery

Enhancement of Antimicrobial Activity of Suppress Release Amoxicillin Camphor Complexed Mucoadhesive Tablets by Statistical Experimental Design

Phenoxymethylpenicillin–intercalated hydrotalcite as a bacteria inhibitor

Contact Info

Product

Resources

About