Use of highly potent bisphosphonates in the treatment of osteoporosis

Abstract

Bisphosphonates are effective inhibitors of bone remodeling. In the clinical setting, these agents prevent bone loss, preserve bone architecture, and improve bone strength. Clinically significant reduction in the risk of spine and nonspine fractures is observed in patients known to be at risk for fracture. When administered appropriately, these drugs are well tolerated and have an excellent safety profile. Potent bisphosphonates are now the preferred treatment option to reduce the fracture risk in men and women with involutional and glucocorticoid-induced osteoporosis.

Potential Effect of Alendronate on Tooth Eruption and Molar Root Formation in Young Growing and Osteoprotic Albino Rats (A Histological and Histochemical Study)

“…This might be explained on the basis that sodium alendronate obtains an anti-resorptive effect, and therefore, the eruption pathway was obstructed. (11) Furthermore, Bps including sodium alendronate, are the backbone of treatment of adult bone diseases such as postmenopausal osteoporosis, cancer chemotherapy, in the prevention of malignant tumor bone metastasis , and alleviating bone pain caused by radiotherapy . Since this drug is also indicated in the therapy of several pediatric bone disorders.…”

Estudo da osteoclastogênese e da remodelação óssea durante a formação e erupção de molares de ratos tratados com bisfosfonatos.

“…Bisphosphonates, including sodium alendronate, are the mainstay of treatment of adult bone diseases such as postmenopausal osteoporosis (McClung 2003;Greenblatt 2005), cancer chemotherapy, the prevention of malignant tumor bone metastasis (Santini et al 2003;Muller at al. 2005), and bone pain caused by radiotherapy (Lussier et al 2004).…”