Use of heparinized bacterial cellulose based scaffold for improving angiogenesis in tissue regeneration

Wang, Baoxiu; Lv, Xiangguo; Chen, Shiyan; Li, Zhe; Yao, Jingjing; Peng, Xufeng; Cao, Feng; Xu, Yuhong; Wang, Huaping

doi:10.1016/j.carbpol.2017.11.055

Cited by 57 publications

(43 citation statements)

References 48 publications

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“…Scaffolds fabricated from cellulose, using both ''top-down'' and ''bottom-up'' approaches, have been tested in a range of cell culture applications. [40][41][42][43] Cellulose offers many beneficial attributes to tissue engineering, such as biocompatibility, versatile chemical and physical properties, and ease of processing. It is also a cost effective and sustainable material, which makes it suitable for industrial applications.…”

Section: Introductionmentioning

confidence: 99%

Mechanically robust cationic cellulose nanofibril 3D scaffolds with tuneable biomimetic porosity for cell culture

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Mechanically robust cationic cellulose nanofibril 3D scaffolds with tuneable biomimetic porosity for cell culture

et al. 2019

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“…An implanted BC scaffold on mice (Figure 7) has for instance shown to harbor favorable condition for angiogenesis as well as trigger no inflammatory response, and from these implantation studies, the onset of angiogenesis was observed as soon as 1 week after implantation [108]. In a different approach, heparinized BC provided a means for controlled release of VEGF to promote vascularization, and in recent studies have shown detectible angiogenesis in vivo as soon as 2 weeks after implantation with blood vessel density ranging from 1.35% to 2.61% [109]. In a more direct approach, artificial blood vessels have been fabricated from BC and have shown promising results in animal studies where artificial vessels possessed acceptable in vitro hemolytic rates (0.097%-0.42%) with no apparent triggering of immune cells providing a strong indication of its biocompatibility [99].…”

Section: Medical Application and Marketed Products From Bacterial Celmentioning

confidence: 87%

Engineering Bacterial Cellulose for Diverse Biomedical Applications

Sandhu¹,

Arpa²,

Chen³

et al. 2019

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Increasing interest in bacterial cellulose due to the huge potential which exists for the development of this new biomaterial for medical applications has been met with recent growth in research in engineering this unique microbial manufactured material. The mechanical properties, porosity, and biocompatibility of bacterial cellulose derived biomaterials are particularly attractive for use in wound healing, tissue engineering, and drug delivery applications. Advances in synthetic biology and soft materials engineering are pushing the value of this biomaterial to new levels. This review provides and in-depth discussion of these most recent approaches in processing as well as physical, chemical, and genetic modification of bacterial cellulose toward further improvement and expansion of its functionality. In addition, we provide specific attention to the marketed applications of the resulting engineered materials for medical research and conclude with prospective areas of consideration for expanding the clinical utility of this biomaterial to new directions.

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“…3D porous scaffolds from bacterial cellulose/gelatin composites were surface modified with heparin, via a condensation reaction, in order to bind VEGF onto the surface through electrostatic interactions between negatively charged N - and O -sulfated groups of heparin and the basic lysine and arginine residues of VEGF. By fixing VEGF onto the scaffold surfaces, the sustained delivery of VEGF, required to facilitate the production of new blood vessels in the tissue construct, was enabled [ 80 ].…”

Section: Methods Of Scaffold Modificationmentioning

confidence: 99%

Recent Advances in Modified Cellulose for Tissue Culture Applications

2018

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Tissue engineering is a rapidly advancing field in regenerative medicine, with much research directed towards the production of new biomaterial scaffolds with tailored properties to generate functional tissue for specific applications. Recently, principles of sustainability, eco-efficiency and green chemistry have begun to guide the development of a new generation of materials, such as cellulose, as an alternative to conventional polymers based on conversion of fossil carbon (e.g., oil) and finding technologies to reduce the use of animal and human derived biomolecules (e.g., foetal bovine serum). Much of this focus on cellulose is due to it possessing the necessary properties for tissue engineering scaffolds, including biocompatibility, and the relative ease with which its characteristics can be tuned through chemical modification to adjust mechanical properties and to introduce various surface modifications. In addition, the sustainability of producing and manufacturing materials from cellulose, as well as its modest cost, makes cellulose an economically viable feedstock. This review focusses specifically on the use of modified cellulose materials for tissue culturing applications. We will investigate recent techniques used to promote scaffold function through physical, biochemical and chemical scaffold modifications, and describe how these have been utilised to reduce reliance on the addition of matrix ligands such as foetal bovine serum.

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Use of heparinized bacterial cellulose based scaffold for improving angiogenesis in tissue regeneration

Cited by 57 publications

References 48 publications

Mechanically robust cationic cellulose nanofibril 3D scaffolds with tuneable biomimetic porosity for cell culture

Mechanically robust cationic cellulose nanofibril 3D scaffolds with tuneable biomimetic porosity for cell culture

Engineering Bacterial Cellulose for Diverse Biomedical Applications

Recent Advances in Modified Cellulose for Tissue Culture Applications

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