Use of guaiacol glycerine ether in clinical anaesthesia in the horse

Abstract

Summary A total of 103 anaesthetic inductions were performed in horses for a variety of elective procedures. All cases were premedicated with acepromazine maleate (0.02 to 0.05 mg/kg body weight [bwt] intramuscularly [im]). In 50 cases (Group A) anaesthesia was induced by a single intravenous (iv) bolus of thiopentone sodium (11.1 mg/kg bwt or 1 g/90 kg bwt) followed immediately by a bolus of suxamethonium chloride (0.1 mg/kg bwt). In 53 cases (Group B) anaesthesia was induced using iv guaiacol glycerine ether (GGE) (approximately 50 mg/kg bwt) followed by a bolus of thiopentone at half the usual dose rate (5.6 mg/kg bwt or 1 g/180 kg bwt). Induction of anaesthesia was uneventful in both groups although in Group B it was particularly smooth. Following endotracheal intubation anaesthesia was maintained with halothane in oxygen administered via a circle system. The duration of anaesthesia was comparable between the two groups; however, the mean (± sd) time to standing in Group B, 35 ± 22 mins, was significantly shorter than in Group A, 48 ± 25 mins. The use of the GGE/thiopentone technique is discussed.

Does the induction agent affect the course of halothane anaesthesia in horses?

“…Thiopentone, guaiphenesin and xylazine have been used in equine anaesthesia for many years (Brouwer 1985, Hall and Clarke 1991, Matthews et a1 1993. Muir et nl(1979) described the effects of a range of induction techniques before halothane anaesthesia but none of them was the same as in this study.…”

Methods to Induce Analgesia and Anesthesia in Crustaceans: A Supportive Decision Tool

“…Guaiacol glyceryl ether , also known as Guaifenesin, is a constituent of guaiac resin from the wood of Guajacum officinale and has been used as anesthetic in vertebrates [ 148 ]. Oswald [ 45 ] tested the anesthetic properties of this compound in two species of crabs ( C. pagurus and C. maenas ) by an injection of up to 0.4 mL of a 5% solution.…”

Tuning the Lewis acid phenol $$\varvec{ortho}$$ o r t h o -prenylation as a molecular diversity tool

“…Next, we aimed to expand the scope of the reaction using the optimized conditions on the methoxyphenol isomers (3- methoxyphenol 8 and 2-methoxyphenol 9). These substrates have interesting biological properties as antiseptic [33] and local anesthetic agents [34]. When the reaction was applied to meta-methoxy phenol 8, compounds 10-17 were obtained with higher yields than the compounds obtained using 4-methoxy phenol 1.…”