Use of gold nanoshells to mediate heating induced perfusion changes in prostate tumors

Shetty, Anil; Elliott, Andrew M.; Schwartz, Jon A.; Wang, James; Esparza‐Coss, Emilio; Klumpp, Sherry A.; Taylor, Brian; Hazle, John D.; Stafford, R. Jason

doi:10.1117/12.763160

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…The temperature rise was monitored in real time using MR thermometry and increases in perfusion were measured by MR dynamic contrast‐enhanced (DCE) imaging to observe changes in perfusion before and after each hyperthermia treatment. These results indicate that this nanoshell mediated heating can be used to improve perfusion and subsequently enhance drug delivery (Shetty et al, ).…”

Section: Applications With Nanomedicinesmentioning

confidence: 88%

“…Plasmonic gold nanostructures, thus, show great promise for the selective PPTT of cancer as well as other diseases . The different gold nanostructures that have shown this property include nanoshells (Gobin et al, 2007;Hirsch et al, 2003;Lal et al, 2008;O'Neal et al, 2004;Shetty et al, 2008), nanorods (Hauck et al, 2008;Huang et al, 2006;Huff et al, 2007;Jang et al, 2011;Niidome et al, 2009), and nanocages (Chen et al, 2005(Chen et al, , 2007(Chen et al, , 2010Hu et al, 2006b).…”

Section: Methods Of Local Heat Generation For Treatment Of Cancer Phomentioning

confidence: 99%

“…This approach aims to increase perfusion and vascular permeability leading to favorable effects on extravasation in treated tumor areas. To achieve increased perfusion for enhancing drug delivery, gold nanoshells have been used to mediate the thermal effects (Shetty et al, ). Gold nanoshells were delivered to the tumor site by passive extravasation and retention of the circulating nanoshells from the tumor vasculature into the tumor interstitium.…”

Section: Applications With Nanomedicinesmentioning

confidence: 99%

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Hyperthermia approaches for enhanced delivery of nanomedicines to solid tumors

Frazier

Ghandehari²

2015

Biotech & Bioengineering

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Drug delivery to solid tumors has received much attention in order to reduce harmful side effects and improve the efficacy of treatment. Different strategies have been utilized with nanoparticle drug delivery systems, or nanomedicines, including passive and active targeting strategies, as well as the incorporation of stimuli sensitivity. Additionally, hyperthermia has been used in combination with such systems to further improve accumulation, localization, penetration, and subsequently efficacy. Localized hyperthermia within the solid tumor tissue can be applied through different mechanisms able to trigger vascular and cellular mechanisms for enhanced delivery of nanomedicines. This review covers the use of nanoparticles in drug delivery, the different methods for inducing localized hyperthermia, combination effects of hyperthermia, and successful strategies for improving the delivery of nanomedicines using hyperthermia.

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Section: Applications With Nanomedicinesmentioning

confidence: 88%

Section: Methods Of Local Heat Generation For Treatment Of Cancer Phomentioning

confidence: 99%

Section: Applications With Nanomedicinesmentioning

confidence: 99%

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Hyperthermia approaches for enhanced delivery of nanomedicines to solid tumors

Frazier

Ghandehari²

2015

Biotech & Bioengineering

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“…AuNSs demonstrating plasmon resonance in this tissue window, exhibit strong absorption and scattering characteristics depending on their morphology and can be useful bioimaging and photothermal ablation agents [ 28 , 29 ]. The gold shell filled with the aqueous embedding medium should be large enough to allow prolonged blood circulation time for biomedical applications [ 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Numerical Study on the Surface Plasmon Resonance Tunability of Spherical and Non-Spherical Core-Shell Dimer Nanostructures

Fernandes

Kang

2021

Nanomaterials

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The near-field enhancement and localized surface plasmon resonance (LSPR) on the core-shell noble metal nanostructure surfaces are widely studied for various biomedical applications. However, the study of the optical properties of new plasmonic non-spherical nanostructures is less explored. This numerical study quantifies the optical properties of spherical and non-spherical (prolate and oblate) dimer nanostructures by introducing finite element modelling in COMSOL Multiphysics. The surface plasmon resonance peaks of gold nanostructures should be understood and controlled for use in biological applications such as photothermal therapy and drug delivery. In this study, we find that non-spherical prolate and oblate gold dimers give excellent tunability in a wide range of biological windows. The electromagnetic field enhancement and surface plasmon resonance peak can be tuned by varying the aspect ratio of non-spherical nanostructures, the refractive index of the surrounding medium, shell thickness, and the distance of separation between nanostructures. The absorption spectra exhibit considerably greater dependency on the aspect ratio and refractive index than the shell thickness and separation distance. These results may be essential for applying the spherical and non-spherical nanostructures to various absorption-based applications.

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“…For biomedical applications, smaller size (outer diameter, 30-50 nm) allows prolonged blood circulation time and better chance in crossing the tumour vessel wall. The strong and tunable absorption band in NIR regime enables a large penetration depth, even at low laser intensities, that ranges from a few millimeters to several centimeters depending on tissue type [15][16][17]. The hollow core allows higher drug loading capacity, easier synthesis, and the pure gold composition reduces toxicity [18,19].…”

Section: Introductionmentioning

confidence: 99%