Use of Gas Chromatomass Spectroscopy for Analysis of Salicylate Contents in Plasma from Patients with Cerebrovascular Diseases Taking Aspirin as Antiaggregant Therapy

Абаимов, Д. А.; Spavronskaya, L. R.; Шабалина, А.А.; Tanashyan, M. M.; Sariev, A. K.

doi:10.1007/s11094-019-01957-6

Cited by 5 publications

(1 citation statement)

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“…The latent period of aggregation was estimated in the collagen-induced aggregation test and corresponded to the release of platelets. The reference drug was acetylsalicylic acid (powder substance; Shandong Xinhua Pharmaceutical Co. Ltd., China) [13].…”

Section: Experimental Biological Partmentioning

confidence: 99%

Synthesis and Antiaggregant and Anticoagulant Activity of New 1-(4-Alkyloxybenzyl)-1H-Azoles and 1-(Adamantyl-1)-2-[4-(1H-Azol-1-Ylmethyl)-Phenoxy]Ethanones

et al. 2021

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The development and optimization of synthetic methods for alkyl esters of 4-[(1H-azol-1-yl)methyl]phenols enabled the expansion of organic synthesis methodology, which is extremely important for designing new structures with various types of biological activity, e.g., antiaggregant and anticoagulant. The present work studied O-alkylation of 4-[(1H-azol-1-yl)methyl]phenols with various alkylating agents, e.g., n-octyl bromide, n-hexadecyl bromide, and (adamantyl-1)bromomethylketone. The newly synthesized compounds were identified using elemental analysis and IR and PMR spectroscopy. Laboratory studies of blood isolated from healthy volunteers revealed compounds with antiaggregant and anticoagulant properties.

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Section: Experimental Biological Partmentioning

confidence: 99%