Use of fine‐needle aspiration cytology in the diagnosis of parotid neoplasms

Henrys, Courtenay; Grigg, Roger

doi:10.1111/ans.12939

Cited by 20 publications

(19 citation statements)

References 29 publications

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“…45,46 Eight studies removed indeterminate results from their calculations, 22,27,47–52 and in 4 studies, it was unclear how indeterminate results were managed. 10,32,53,54 Finally, 4 studies presented the raw data and did not calculate sensitivity or specificity. 25,28,55,56 …”

Section: Resultsmentioning

confidence: 99%

Sensitivity, Specificity, and Posttest Probability of Parotid Fine‐Needle Aspiration

Liu

Jethwa²,

Khariwala³

et al. 2015

Otolaryngol.--head neck surg.

155

133

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Objectives (1) To analyze the sensitivity and specificity of fine-needle aspiration (FNA) in distinguishing benign from malignant parotid disease. (2) To determine the anticipated posttest probability of malignancy and probability of non-diagnostic and indeterminate cytology with parotid FNA. Data Sources Independently corroborated computerized searches of PubMed, Embase, and Cochrane Central Register were performed. These were supplemented with manual searches and input from content experts. Review Methods Inclusion/exclusion criteria specified diagnosis of parotid mass, intervention with both FNA and surgical excision, and enumeration of both cytologic and surgical histopathologic results. The primary outcomes were sensitivity, specificity, and posttest probability of malignancy. Heterogeneity was evaluated with the I2 statistic. Meta-analysis was performed via a 2-level mixed logistic regression model. Bayesian nomograms were plotted via pooled likelihood ratios. Results The systematic review yielded 70 criterion-meeting studies, 63 of which contained data that allowed for computation of numerical outcomes (n = 5647 patients; level 2a) and consideration of meta-analysis. Subgroup analyses were performed in studies that were prospective, involved consecutive patients, described the FNA technique utilized, and used ultrasound guidance. The I2 point estimate was >70% for all analyses, except within prospectively obtained and ultrasound-guided results. Among the prospective subgroup, the pooled analysis demonstrated a sensitivity of 0.882 (95% confidence interval [95% CI], 0.509–0.982) and a specificity of 0.995 (95% CI, 0.960–0.999). The probabilities of nondiagnostic and indeterminate cytology were 0.053 (95% CI, 0.030–0.075) and 0.147 (95% CI, 0.106–0.188), respectively. Conclusion FNA has moderate sensitivity and high specificity in differentiating malignant from benign parotid lesions. Considerable heterogeneity is present among studies.

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Section: Resultsmentioning

confidence: 99%

Sensitivity, Specificity, and Posttest Probability of Parotid Fine‐Needle Aspiration

Liu

Jethwa²,

Khariwala³

et al. 2015

Otolaryngol.--head neck surg.

155

133

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“…Fakhry et al accepted suspicious cytology as malignant, but ruled out 39 patients with indeterminate cytology before calculating sensitivity (79.6%) and specificity. Henrys and Grigg, Tew et al, and Araújo Filho et al also excluded nondefinitive cases from statistical analysis in their study.…”

Section: Discussionmentioning

confidence: 99%

Application of Sal classification to parotid gland fine‐needle aspiration cytology: 10‐year retrospective analysis of 312 patients

et al. 2018

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“…US and FNAB contribute to the diagnostic work-up of parotid neoplasms. [18] The malignancy detection rate of ultrasound-guided FNAB for parotid tumors is remarkable, whereas its diagnostic accuracy in tumor typing and grading is low. [19,20] Intraoperative frozen sections have been reported to be superior in tumor typing and grading in comparison to FNAB.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Synchronous Mucoepidermoid Carcinoma of Parotid Gland

et al. 2018

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M ucoepidermoid carcinoma is the most common malignant tumor of the parotid gland. [1, 2] It usually occurs as a unilateral lesion and accounts for 30% of malignant salivary gland tumors. [2] Bilateral mucoepidermoid carcinoma of the parotid gland is rarely encountered and may occur synchronously or metachronously. [1, 3-6] In the present case, we report a patient with synchronous bilateral mucoepidermoid carcinoma of the parotid gland.

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Use of fine‐needle aspiration cytology in the diagnosis of parotid neoplasms

Abstract: FNAC is a useful tool in the evaluation of parotid masses but should be used with caution in identifying neoplastic subtypes.

Cited by 20 publications

References 29 publications

Sensitivity, Specificity, and Posttest Probability of Parotid Fine‐Needle Aspiration

Sensitivity, Specificity, and Posttest Probability of Parotid Fine‐Needle Aspiration

Application of Sal classification to parotid gland fine‐needle aspiration cytology: 10‐year retrospective analysis of 312 patients

Bilateral Synchronous Mucoepidermoid Carcinoma of Parotid Gland

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