Use of extrusion aids for successful production of Kollidon^® CL-SF pellets by extrusion–spheronization

Abstract

PEO proved to be an exceptional extrusion-spheronization aid in the preparation of pellets using K CL-SF. It facilitated wetted mass extrusion with minimal mass loss to the extruder, and markedly improved the sphericity of the pellets produced by marumerization. Immediate release pellets were obtained.

Evaluation of Experimental Multi-Particulate Polymer-Coated Drug Delivery Systems with Meloxicam

“…where P EQPC is the perimeter of a circle that has an area equivalent to that of the pellet image and P real represents the perimeter of the pellet image [37].…”

“…According to the ImageJ software manual and to scientific literature [35][36][37][38], for either circularity or aspect ratio, values closer to 1 indicate that the photographed objects have a circular shape. Thus, it can be assumed that the closer the values of these two parameters are closer to 1, the more spherical the pellets are.…”

A brief review on Kollidon

“…Kollidon CL-SF is the most excellent crospovidone grade for disintegration purposes, and it has a good disintegration power and fewer surface defects of the tablets after humid storage. This grade is perfect for fast disintegrating buccal tablets A current literature review on kollidon CL-SF based research publication N. C. Loka et al [15]shows that immediate release pellets were prepared by wetted mass extrusion method, and markedly improved the sphericity of the pellets produced by marumerization. A. Amelian et al [16]formulated orally disintegrating loratadine tablet manufactured with co-processed mixture (Kollidon CL-F, CL-SF) by direct compression method, prepared tablets was of appropriate mechanical properties, disintegration time below 30 seconds was observed in formulation with crospovidone as disintegrant.…”