Use of exhaled breath condensate to investigate occupational lung diseases

Corradi, Massimo; Gergelová, Petra; Mutti, Antonio

doi:10.1097/aci.0b013e3283357fb7

Cited by 52 publications

(43 citation statements)

References 29 publications

(22 reference statements)

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“…This study supports the confidence that the noninvasive technique of EBC may contribute to a better understanding of the pathogenesis of silicosis and asbestosis and related findings, such as leukotrienes and anti-neutrophil cytoplasmic antibodies (ANCA) involvement [18][19][20] ; and presumably to the monitoring of the activity of these still-incurable lung diseases.…”

Section: Resultssupporting

confidence: 78%

Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases

et al. 2011

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Exhaled breath condensate (EBC) is assumed to reflect processes in the lungs, yet itis unknown whether oxidative stress markers in EBC are affected by systemic disorders (atherosclerosis, hypertension, diabetes) or whether lung diseases increase markers in plasma and urine. 8-isoprostane, 4-hydroxy-trans-2-nonenale (HNE) and malondialdehyde (MDA) were measured using liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS/MS) in EBC, plasma and urine in 82 patients (45 with asbestosis and hyalinosis, and 37 with silicosis) and in 29 control subjects. 8-isoprostane and HNE in EBC, and HNE in urine were higher in both groups of patients. In addition, 8-isoprostane in plasma and urine, and MDA in urine were higher in asbestos-exposed patients and MDA in plasma in silicotics, with this marker in plasma correlated with the grade of silicosis. In all subjects, 8-isoprostane in EBC correlated with urine (r=0.38, p<0.001) and plasma levels (r=0.28, p=0.003), and HNE and MDA with urine levels (r=0.31, p<0.001; r=0.23, p=0.016, respectively). Most markers positively correlated with lung function impairment, EBC markers negatively with vitamin E supplementation. To conclude: The influence of satisfactorily controlled systemic disorders on markers in EBC in patients with pneumoconioses is not significant. In addition to oxidative stress markers in EBC, lung fibroses may increase oxidative stress markers in plasma and urine.

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Section: Resultssupporting

confidence: 78%

Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases

et al. 2011

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“…In occupational pneumology, different biomarkers of the effect, such as oxidative stress and inflammatory-derived markers have been applied in the investigation of asthma and pneumoconiosis, which may contribute to studying the pathological state of the lungs of workers with previous exposure to fibrogenic and carcinogenic dusts, such as asbestos and silica 1) . For patients with asbestosis and silicosis, no treatment is available, and a chronic progression is typical even decades after the end of exposure due to the retention of fibrogenic particles in the lungs.…”

Section: Introductionmentioning

confidence: 99%

Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis

Pelclová¹,

Fenclová²,

Vlčková³

et al. 2012

Ind Health

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Leukotrienes (LTs) are involved in the pathogenesis of lung fibrosis and were increased in exhaled breath condensate (EBC) of the patients with pneumoconiosis. However the possible influence of extra-pulmonary disorders on the EBC markers is not known. Therefore in parallel with EBC, LTs' levels in the plasma and urine were measured in patients with pneumoconiosis (45 × asbestos exposure, 37 × silica exposure) and in 27 controls. Individual LTs B4, C4, D4 and E4 were measured by liquid chromatography − electrospray ionization − tandem mass spectrometry (LC-ESI-MS/MS). In EBC, LT D4 and LT E4 were increased in both groups of patients (p<0.001 and p<0.05), comparing with the controls. Both LT B4 and cysteinyl LTs were elevated in asbestosexposed subjects (p<0.05). Asbestosis with more severe radiological signs (s1/s2-t3/u2) and lung functions impairment has shown higher cysteinyl LTs and LT C4 in the EBC (p<0.05) than mild asbestosis (s1/s0-s1/s1). In addition, in the subjects with asbestosis, cysteinyl LTs in EBC correlated with TLC (−0.313, p<0.05) and TLCO/Hb (−0.307, p<0.05), and LT C4 with TLC (−0.358, p<0.05). In pneumoconioses, EBC appears the most useful from the 3 fluids studied.

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“…Breath matrix has some advantages such as readiness to use, noninvasiveness and accessibility. Recently, several studies have been performed on the applicability of biomarkers of EBC in both occupational and environmental exposure assessments [14][15][16]. To the best of our knowledge, there is no similar study dealing with the level of MDA in the sampling, and before the next sampling sequence, the condenser was gently washed and rinsed with normal saline and then dried by a hair drier.…”

Section: Introductionmentioning

confidence: 99%

“…There are several studies in which plasma MDA has been used as a marker of oxidative stress for dust exposure scenarios [11,12]. Exhaled breath condensate (EBC) has been proposed as an interesting alternative matrix of biomarkers in the prognosis and diagnosis of lung diseases [13,14]. Breath matrix has some advantages such as readiness to use, noninvasiveness and accessibility.…”

Section: Introductionmentioning

confidence: 99%

Archive About the Journal Instructions for Authors Instructions for Reviewers Editorial Office Editorial Board Contact Reviewers 2014 2013 < PREVIOUS NEXT > ORIGINAL PAPER CC BY-NC 3.0 Polska Exhaled breath malondialdehyde, spirometric results and dust exposure assessment in ceramics production workers

Sakhvidi¹,

Ardekani²,

Firoozichahak³

et al. 2015

Int J Occup Med Environ Health

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Objectives:The study aimed at measuring exhaled breath malondialdehyde (EBC-MDA) in workers exposed to dust containing silica and at its comparison with the non-exposed control group. Material and Methods: The cross sectional, case-control study (N = 50) was performed in a tile and ceramics production factory in Yazd, Iran. EBC-MDA was quantified in exhaled breath of the participants by a lab made breath sampler. Exposure intensity was measured according to the NIOSH 0600 method in selected homogeneous exposure groups. Additionally, spirometry test was conducted to investigate a correlation between EBC-MDA and spirometric findings in the exposed workers. Results: There was no difference in the observed exposure intensities of silica containing dust in different units. However, "coating preparation" was the unit with the highest concentration of dust. Although, the level of EBC-MDA in the cases was slightly higher than in the controls, the difference was not statistically significant (U = 252, p = 0.464). A significant and positive correlation was found between dust exposure intensity in working units and the measured EBC-MDA of workers (r = 0.467, N = 25, p = 0.027). There were also no statistically significant differences among job categories in the exposed group for the values of FEV 1 % (F(3, 44) = 0.656, p = 0.584), FVC% (F(3, 44) = 1.417, p = 0.172), and FEV 1 /FVC% (F(3, 44) = 1.929, p = 0.139). Conclusions: The results showed a significant correlation between respirable dust exposure intensity and the level of EBC-MDA of the exposed subjects. However, our results did not show a significant correlation between lung function decreases and EBC-MDA.

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Use of exhaled breath condensate to investigate occupational lung diseases

Cited by 52 publications

References 29 publications

Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases

Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases

Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis

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