The popular use of medicinal plants in healthcare practices among the indigenous communities provides the basis for natural drug discovery development. The present research was aimed to document detailed ethnoveterinary knowledge of medicinal plants used for medicinal purposes. The field study was carried out from January 2016 to December 2020 in Zemmour and Zayane tribes (Middle Atlas). In total, 300 local informants were interviewed, using open-ended and semi-structured interviews. The benefits, coverage, and importance of ethnoveterinary was expressed through several quantitative indices including Informant Consensus Factor (FIC), Fidelity Level (FL), Relative Popularity Level (RPL), Rank Order Priority (ROP), and Jaccard Index (JI). A total of 150 plant species belonging to 129 genera and 56 families were found to be used in ethnoveterinary practices. The most commonly used ethnoveterinary plant species in the study areas was Allium sativum L. (16.7%). Leaves were found to be the most frequent plant part used (46.5%). The highest FIC value was 0.9 for digestive disorders. Artemisia herba-alba Asso and Asparagus officinalis L. show a 100% fidelity level for diarrhea and rabies respectively. Rank Order Priority (ROP) results showed that Eucalyptus globulus Labill. (ROP=74), was the most preferred species for the treatment of fever. The present study showed that local communities in the Middle Atlas have consistent knowledge of ethnoveterinary plants. We invite the attention of chemists and pharmacologists for further phytochemical and pharmacological investigations of medicinal plants having high ROP, FL, and FIC values in this study. that includes the use of plant-based medicines to cure human and animal health [3].Ethnoveterinary medicine (EVM) is a system based on folk traditional skills, methods, knowledge, theories, beliefs, and practices for curing various diseases, healthful husbandry, and maintaining good health of our animals [4][5][6].This knowledge and skills of ethnoveterinary practices are learned through experience and transmitted orally from generation to generation [7]. Today, despite industrial development, this traditional knowledge has vanished in some parts of the developed world [6]. This constitutes a threat to the evolution and sustainability of indigenous knowledge over time. The importance of this body of knowledge is best explained by the African proverb, "When a knowledgeable old person dies, a whole library disappears" [8]. On the other hand, EVM is still playing an important role in livelihood development and sustainable livestock farming in many poor rural areas of the globe [9], and often becomes the only available means for farmers to treat animals illnesses. The use of EVM to control livestock diseases has been cited by the World Health Organization [10], who estimated that 80% of the population living in developing countries relies exclusively on traditional medicine for their primary health care.More than half of the world's population still relies entirely on plants for medic...