Use of Complementary and Alternative Medicine in Patients with Gynecologic Cancer: a Systematic Review

Akpunar, Dercan; Bebiş, Hatice; Yavan, Tülay

doi:10.7314/apjcp.2015.16.17.7847

Cited by 37 publications

(37 citation statements)

References 24 publications

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“…This herbs catching level may appear pretty low comparative to previous studies (Bishop et al, 2010(Bishop et al, , 2011Engdal et al, 2009;Sewitch & Rajput, 2010;Sparreboom et al, 2004). Nevertheless, it can be explained by the under-representation of clinicians specialised in gynaecologic cancers, CAMs catching being frequently and massively observed in gynaecologic cancer patients (Akpunar, Bebis, & Yavan, 2015 T A B L E 3 (Continued) appreciation of HDI by clinicians. This assertion is confirmed by the massive adhesion (around 90%) to the proposal to build a specific tool to evaluate risk of HDI.…”

Section: Discussionmentioning

confidence: 83%

Development of a rapid risk evaluation tool for herbs/drugs interactions in cancer patients: a multicentric experience in south of France

et al. 2017

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Cancer patients use herbs in spite of severe interactions risks with major anticancer drugs. In daily practice, it is very difficult for oncologists to detect and define the risk of a herb-anticancer drug interaction (HDI). In this work, we realised a state of play in one of the most populated region of France by evaluating, through a specific questionnaire, the position of a representative panel of oncologists. About 80% of them thought that herbs interact with anticancer treatments whereas only 15.4% of them actually knew the real HDI. About 89.1% of them thought that a practical detection tool would be relevant and useful for their daily practice. Then, we constructed a tool in order to rapidly evaluate a HDI risk level. Based on experts' reviews and using a criticality matrix, we determined the HDI risk level between 11 herbs and 126 anticancer drugs. Then, we measured satisfactory of oncologists. All of them considered the tool as useful in their daily practice and then used it. This work highlighted that even if HDI has been integrated as a theoretical risk, its practical detection and risk evaluation is difficult to implement for oncologists in their daily practice. Thus, the tool we developed should answer to an unmet medical need.

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Section: Discussionmentioning

confidence: 83%

Development of a rapid risk evaluation tool for herbs/drugs interactions in cancer patients: a multicentric experience in south of France

et al. 2017

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“…Systematic reviews have reported that 40 to 90% of patients with breast or gynecology cancers have taken alternative medicines while on oncology treatments or follow-up. 8 In this context, several supposedly "miracle drugs" such as herbs, vitamins, and fruit extracts, among others, have appeared in different countries. Commotion is expected within the society because cancer patients and their relatives are desperate to try anything that could cure or prolong their lives.…”

Section: Discussionmentioning

confidence: 99%

A "miracle" cancer drug in the era of social media: A survey of Brazilian oncologists' opinions and experience with phosphoethanolamine

Rêgo

Lopes

Riechelmann

et al. 2017

Rev. Assoc. Med. Bras.

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“…Alternative or complementary medical practices (ACMPs) encompass the medical and veterinary use of therapies that are not routinely offered by and/or accepted by the traditional care systems, but that has attracted the attention of thousands of people in different countries [1, 2]. The ACMPs include different interventions such as electrotherapy [3–5], Ayurveda [6], biofeedback [7], hypnosis [8], “energy healing therapy”/Reiki [9], special diets (such as vegetarian and macrobiotic) [10], Yoga [11], autohemotherapy [12], and homeopathy [13] among others [14, 15].…”

Section: Introductionmentioning

confidence: 99%

Impact of autologous whole blood administration upon experimental mouse models of acute Trypanosoma cruzi infection

Pavão

Demarque

Batista

et al. 2018

J Venom Anim Toxins Incl Trop Dis

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BackgroundAutologous whole blood (AWB) administration is described as alternative/complementary medical practice widely employed in medical and veterinary therapy against infections, chronic pathologies and neoplasias. Our aim is to investigate in vivo biological effect of AWB using healthy murine models under the course of Trypanosoma cruzi acute infection.MethodsThe first set of studies consisted of injecting different volumes of AWB and saline (SAL) into the posterior region of quadriceps muscle of healthy male Swiss mice under distinct therapeutic schemes evaluating: animal behavior, body and organ weight, hemogram, plasmatic biochemical markers for tissue damage and inflammatory cytokine levels and profile. To assess the impact on the experimental T. cruzi infection, different schemes (prior and post infection) and periods of AWB administration (from one up to 10 days) were conducted, also employing heterologous whole blood (HWB) and evaluating plasma cytokine profile.ResultsNo major adverse events were observed in healthy AWB-treated mice, except gait impairment in animals that received three doses of 20 μL AWB in the same hind limb. AWB and SAL triggered an immediate polymorphonuclear response followed by mononuclear infiltrate. Although SAL triggered an inflammatory response, the kinetics and intensity of the histological profile and humoral mediator levels were different from AWB, the latter occurring earlier and more intensely with concomitant elevation of plasma IL-6. Inflammatory peak response of SAL, mainly composed of mononuclear cells with IL-10, was increased at 24 h. According to the mouse model of acute T. cruzi infection, only minor decreases (< 30%) in the parasitemia levels were produced by AWB and HWB given before and after infection, without protecting against mortality. Rises in IFN-gamma, TNF-alpha and IL-6 were detected at 9 dpi in all infected animals as compared to uninfected mice but only Bz displayed a statistically significant diminution (p = 0.02) in TNF-alpha levels than infected and untreated mice.ConclusionsThis study revealed that the use of autologous whole blood (AWB) in the acute model employed was unable to reduce the parasitic load of infected mice, providing only a minor decrease in parasitemia levels (up to 30%) but without protecting against animal mortality. Further in vivo studies will be necessary to elucidate the effective impact of this procedure.

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Use of Complementary and Alternative Medicine in Patients with Gynecologic Cancer: a Systematic Review

Cited by 37 publications

References 24 publications

Development of a rapid risk evaluation tool for herbs/drugs interactions in cancer patients: a multicentric experience in south of France

Development of a rapid risk evaluation tool for herbs/drugs interactions in cancer patients: a multicentric experience in south of France

A "miracle" cancer drug in the era of social media: A survey of Brazilian oncologists' opinions and experience with phosphoethanolamine

Impact of autologous whole blood administration upon experimental mouse models of acute Trypanosoma cruzi infection

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