Use of clindamycin as an alternative antibiotic prophylaxis

Maisat, Wiriya; Bermudez, Marie; Yuki, Koichi

doi:10.1016/j.pcorm.2022.100278

Cited by 1 publication

(2 citation statements)

References 29 publications

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“…The overuse of clindamycin, vancomycin and gentamicin was associated with a 50% increased risk of an SSI versus cefazolin monotherapy [61]. This may be due clindamycin resistance by both Group A streptococci and S. aureus being near 50% in many regions [62 ▪ ,63]. Clindamycin also has an increased risk of C. difficile infection in this population [62 ▪ ].…”

Section: Surgical Antibiotic Prophylaxismentioning

confidence: 92%

“…This may be due clindamycin resistance by both Group A streptococci and S. aureus being near 50% in many regions [62 ▪ ,63]. Clindamycin also has an increased risk of C. difficile infection in this population [62 ▪ ]. Norvell et al confirmed that using cefazolin over a second line antimicrobial prophylaxis in total hip or knee arthroplasties had fewer SSI (0.9% vs 3.8%; P < .001) and PJI (0.1% vs 1.9%) [59 ▪▪ ].…”

Section: Surgical Antibiotic Prophylaxismentioning

confidence: 99%

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Using antibiotics wisely

Jung,

Cozzi,

Forrest

2023

Current Opinion in Infectious Diseases

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Purpose of review This review will describe role of shorter antibiotic therapies, early switch from intravenous to oral therapy, and artificial intelligence in infectious diseases. Recent findings There is evidence that shorter courses of antibiotics are noninferior to standard durations of therapy. This has been demonstrated with Enterobacterales bacteremia that can be treated with 7 days of therapy, community acquired pneumonia with 3 days and ventilator associated pneumonia with just 7 days of antibiotic therapy. The conversion from intravenous to oral therapy in treating bacteremia, endocarditis and bone and joint infections is safe and effective and reduces line complications and costs. Also, for clean surgical procedures only one dose of antibiotic is needed, but it should be the most effective antibiotic which is cefazolin. This means avoiding clindamycin, removing penicillin allergies where possible for improved outcomes. Finally, the role of artificial intelligence to incorporate into using antibiotics wisely is rapidly emerging but is still in early stages. Summary In using antibiotics wisely, targeting such as durations of therapy and conversion from intravenous antibiotic therapy to oral are low hanging fruit. The future of artificial intelligence could automate a lot of this work and is exciting but needs to be proven. Video abstract http://links.lww.com/COID/A50

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Section: Surgical Antibiotic Prophylaxismentioning

confidence: 92%