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The crystal structure of a metastable, internal ligand-bound conformation of the αXβ2 integrin suggests it enables rapid equilibration between the bent-closed and extended-open conformational states.

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Children with major and severe CHD, undergoing noncardiac surgery, have an increased risk of mortality compared with children without CHD. Further studies need to identify the optimal environment for surgical procedures, develop trained multidisciplinary teams to care for children with CHD, and define management strategies for improving outcomes in this high-risk population.

Glycerophospholipids are structural and func-