Use of chondral fragments for one stage cartilage repair: A systematic review

Bonasia, Davide Edoardo; Marmotti, A.; Rosso, Federica; Collo, G; Rossi, Roberto

doi:10.5312/wjo.v6.i11.1006

Cited by 40 publications

(33 citation statements)

References 19 publications

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“…This collective of subjects could also represent indicative for particulate or minced cartilage procedures as such technique is gaining rising interest. 13 A recent case report provided an excellent clinical and MR outcome after a spontaneous minced cartilage procedure that was combined with subchondral drilling (a large localized bone marrow edema was present) to simultaneously relieve pressure and revitalize the subchondral bone and the particulate cartilage. 14 The defect in that case report had a lesion diameter of 3.75 cm 2 .…”

Section: Discussionmentioning

confidence: 99%

Second-Generation Autologous Minced Cartilage Repair Technique

Salzmann

Calek

Preiß

2017

Arthroscopy Techniques

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Articular cartilage defects at the knee joint are identified and treated with increasing frequency. Autologous chondrocytes may have the strongest potential to generate high-quality repair tissue within the defective region. Autologous chondrocyte implantation is not available in every country. We present a surgical technique where the surgeon can apply autologous chondrocytes in a one-step procedure to treat articular cartilage defects at the knee joint.

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Section: Discussionmentioning

confidence: 99%

Second-Generation Autologous Minced Cartilage Repair Technique

Salzmann

Calek

Preiß

2017

Arthroscopy Techniques

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“…Moreover, the use of selected precursor cells (i.e., precultured autologous stem cells, chondrocytes) is necessarily associated with multiple procedures to obtain the primary autologous source, to culture the cells and to reimplant the cells at the lesion site. An ongoing solution proposed in literature is the “one-step procedures” in which autologous unselected sources of cells, as bone marrow concentrate [ 24 ], cartilage fragments [ 1 , 25 ], or stromal vascular fraction from lipoaspirates [ 5 ] are added at the lesion site (cartilage or bone defect) obtaining interesting results, even if in these instances, a noncommitted cell population is used to enhance the repair.…”

Section: Discussionmentioning

confidence: 99%

Allogeneic Umbilical Cord-Derived Mesenchymal Stem Cells as a Potential Source for Cartilage and Bone Regeneration: An In Vitro Study

Marmotti

Mattia

Castoldi

et al. 2017

Stem Cells International

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Umbilical cord (UC) may represent an attractive cell source for allogeneic mesenchymal stem cell (MSC) therapy. The aim of this in vitro study is to investigate the chondrogenic and osteogenic potential of UC-MSCs grown onto tridimensional scaffolds, to identify a possible clinical relevance for an allogeneic use in cartilage and bone reconstructive surgery. Chondrogenic differentiation on scaffolds was confirmed at 4 weeks by the expression of sox-9 and type II collagen; low oxygen tension improved the expression of these chondrogenic markers. A similar trend was observed in pellet culture in terms of matrix (proteoglycan) production. Osteogenic differentiation on bone-graft-substitute was also confirmed after 30 days of culture by the expression of osteocalcin and RunX-2. Cells grown in the hypertrophic medium showed at 5 weeks safranin o-positive stain and an increased CbFa1 expression, confirming the ability of these cells to undergo hypertrophy. These results suggest that the UC-MSCs isolated from minced umbilical cords may represent a valuable allogeneic cell population, which might have a potential for orthopaedic tissue engineering such as the on-demand cell delivery using chondrogenic, osteogenic, and endochondral scaffold. This study may have a clinical relevance as a future hypothetical option for allogeneic single-stage cartilage repair and bone regeneration.

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“…Others are, eliminating or reducing any obvious structural deformities, maximizing muscle and joint function, careful placement of any implants, and in recognition of the structure of the diseased tissue, possible enzymatic control to reduce immunogenic responses [64] . The use of weight-bearing activities that match the repair tissue biomechanical properties [65] , pulsed electromagnetic fields and other remedies to quell pain, and joint swelling, in addition to harnessing the multilineage differentiation capacity of osteoarthritis multipotent progenitor cells [42] , or mixing adult and juvenile cartilage fragments [67] and introducing early exercise loading following graft implantation [102] , laser therapy [104][105][106][107][108] , may also favor the initiation of desirable chondrocyte reparative processes.…”

Section: Discussionmentioning

confidence: 99%

Articular Cartilage Regeneration: An Update of Possible Treatment Approaches

Marks¹

2017

International Journal of Orthopaedics

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repair themes in the leading databases were examined. Specific emphasis was placed on a broad array of efforts and observations concerning articular cartilage and its repair. Articles of historic significance and more current strategies designed to foster cartilage repair were focused on, and reported in narrative form. Ideas extracted from the voluminous literature were those that answered one or more of the key questions driving this research. RESULTS: Numerous attempts have been made over time to foster cartilage repair, using a variety of approaches such as creating artificial cartilage, and transplanting stem cells into damaged cartilage to promote repair. Most current strategies are forged in laboratories and do not always account for the complex disease process, and the importance mechanical and inflammatory determinants play in the disease. However, manipulating biophysical, and biomechanical stimuli favorably is likely to hold promise for attenuating destruction of/or for fostering cartilage viability and repair, even in the presence of adverse osteoarthritic cartilage tissue changes. CONCLUSION: More work is needed to examine the key upstream determinants leading to articular cartilage destruction, and to enhancing the viability of the tissue. Employing carefully construed therapeutic strategies known to impact articular cartilage homeostasis safely and effectively can potentially preserve chondrocyte homeostasis, either alone or in conjunction with new technologies.

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Use of chondral fragments for one stage cartilage repair: A systematic review

Abstract: In conclusion, the authors can state that encouraging preliminary results are available for both techniques. However, further studies are necessary to precisely determine the indications, surgical techniques, and long term outcomes for PJAC and CAIS.

Cited by 40 publications

References 19 publications

Second-Generation Autologous Minced Cartilage Repair Technique

Second-Generation Autologous Minced Cartilage Repair Technique

Allogeneic Umbilical Cord-Derived Mesenchymal Stem Cells as a Potential Source for Cartilage and Bone Regeneration: An In Vitro Study

Articular Cartilage Regeneration: An Update of Possible Treatment Approaches

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