Second-Generation Autologous Minced Cartilage Repair Technique

Salzmann, Gian M.; Calek, Anna-Katharina; Preiß, Stefan

doi:10.1016/j.eats.2016.09.011

Cited by 42 publications

(48 citation statements)

References 22 publications

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“…The autologous minced (or particulate) cartilage procedure represents a possible alternative. 4,8,44 After initial reports from Albrecht 1 in the early 1980s, Lu et al 24 were the first to pick up the topic of cartilage piece implantation in the 2000s again. Animal models demonstrated that articular chondrocytes that are brought into a defective region are capable of migrating from their surrounding matrix and establishing a new matrix or that transplanted chips can incorporate within the lesion.…”

Section: Discussionmentioning

confidence: 99%

One-Step Autologous Minced Cartilage Procedure for the Treatment of Knee Joint Chondral and Osteochondral Lesions: A Series of 27 Patients With 2-Year Follow-up

Maßen

Inauen

Harder

et al. 2019

Orthopaedic Journal of Sports Medicine

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Background: Chondral and osteochondral lesions are being detected with increasing frequency. For large-diameter lesions, cell-based treatment modalities are speculated to result in the best possible outcome. Purpose: To prospectively evaluate the 2-year clinical and radiological results after the treatment of chondral and osteochondral knee joint lesions by a single-step autologous minced cartilage procedure. Study Design: Case series; Level of evidence, 4. Methods: From February 2015 to June 2016, a total of 27 consecutive patients suffering from chondral or osteochondral lesions of the knee joint were treated using a single-step autologous minced cartilage procedure. All patients underwent preoperative and postoperative magnetic resonance imaging for the collection of AMADEUS (Area Measurement and Depth and Underlying Structures) and MOCART (magnetic resonance observation of cartilage repair tissue) scores. Clinical analysis was conducted by a numeric analog scale (NAS) for pain and knee function before the intervention and at 12 and 24 months postoperatively. Results: A total of 12 female and 15 male patients (mean age, 28.7 years) were evaluated for a mean of 28.2 ± 3.8 months. The mean cartilage defect size encountered intraoperatively was 3.1 ± 1.6 cm 2 . There was a significant decrease in pain from 7.2 ± 1.9 preoperatively to 1.8 ± 1.6 ( P < .001) at 2-year follow-up. Knee function improved from a mean of 7.2 ± 2.0 preoperatively to 2.1 ± 2.3 ( P < .001) at 2 years after surgery. The mean preoperative AMADEUS score was 57.4 ± 21.4. Postoperatively, the mean MOCART score was 40.6 ± 21.1 at 6-month follow-up. No correlation was observed between the clinical data and the MOCART or AMADEUS scores. Conclusion: Overall, the findings of this study demonstrated that patients undergoing a single-step autologous minced cartilage procedure had a satisfactory outcome at 2-year follow-up. As a result, the single-step autologous minced cartilage procedure does represent a possible alternative to standard autologous chondrocyte implantation. Longer follow-up and larger cohorts are required to define the benefits of this procedure.

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Section: Discussionmentioning

confidence: 99%

One-Step Autologous Minced Cartilage Procedure for the Treatment of Knee Joint Chondral and Osteochondral Lesions: A Series of 27 Patients With 2-Year Follow-up

Maßen

Inauen

Harder

et al. 2019

Orthopaedic Journal of Sports Medicine

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“…The technique has been described before in an open approach. 8 It can be applied arthroscopically at all symptomatic full-thickness cartilage defects of the knee joint including trochlea, both femoral condyles, tibial plateau, and patella surface. In osteochondral defects, a combination of cancellous bone plasty and minced cartilage repair can be performed.…”

Section: Surgical Techniquementioning

confidence: 99%

“…Mostly, fragmented cartilage chips are implanted via an open approach. 8 Fixation has been described by the use of fibrin glue, via a membrane, or a combination of both. Autologous chondrocyte implantation (ACI), currently in its fourth generation, can be established via a full arthroscopic approach.…”

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confidence: 99%

Arthroscopic Minced Cartilage Implantation (MCI): A Technical Note

Schneider¹,

Ossendorff

Holz³

et al. 2021

Arthroscopy Techniques

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Articular cartilage lesions are identified with increasing frequency. Several cartilage repair techniques are available to treat symptomatic cartilage defects. The ultimate goal of any cartilage repair procedure is the prevention of premature osteoarthritis. Autologous chondrocyte implantation provides the best tissue quality. However, 2 operations and a resource-intense culturing process with high regulatory demands are disadvantages of this cartilage repair procedure. Furthermore, cellular dedifferentiation and senescence display further cell culture-associated drawbacks that hamper the procedure. Minced cartilage implantation is a relatively simple and cost-effective one-step procedure with promising biologic potential and satisfying clinical results. We present an arthroscopic surgical technique where the surgeon can apply autologous chondrocytes in a one-step procedure to treat articular cartilage defects at the knee joint.

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“…They noted a return to the preinjury level of play in both patients, with excellent defect filling on MRI (both patients) and arthroscopy (1 patient). Salzmann et al 10 presented a single-step surgical technique of autologous minced cartilage implantation with fibrin glue. However, an open arthrotomy was used in this technique.…”

Section: Pitfallsmentioning

confidence: 99%

Autograft Cartilage Transfer Augmented With Bone Marrow Concentrate and Allograft Cartilage Extracellular Matrix

Lavender

Adil

Singh

et al. 2020

Arthroscopy Techniques

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The use of biologics in sports medicine is increasing rapidly. An osteochondral defect in a young active patient remains a difficult issue to treat. Autograft cartilage has tremendous advantages for the treatment of full-thickness defects, but harvesting and preparation have been difficult in the past. Disadvantages have included donor-site morbidity and the need for further surgery. With the recent development of the GraftNet device (Arthrex, Naples, FL), harvesting and delivery of autograft have become easier and can be performed arthroscopically in a single surgical procedure. Bone marrow concentrate has recently increased in popularity owing to the presence of mesenchymal stem cells. These stem cells combined with autograft cartilage and BioCartilage (Arthrex) could lead to better incorporation and healing. In this article, we show how this unique biological composite is obtained and then added in the cartilage defect during a singlestage arthroscopic procedure.

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Second-Generation Autologous Minced Cartilage Repair Technique

Cited by 42 publications

References 22 publications

One-Step Autologous Minced Cartilage Procedure for the Treatment of Knee Joint Chondral and Osteochondral Lesions: A Series of 27 Patients With 2-Year Follow-up

One-Step Autologous Minced Cartilage Procedure for the Treatment of Knee Joint Chondral and Osteochondral Lesions: A Series of 27 Patients With 2-Year Follow-up

Arthroscopic Minced Cartilage Implantation (MCI): A Technical Note

Autograft Cartilage Transfer Augmented With Bone Marrow Concentrate and Allograft Cartilage Extracellular Matrix

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