Use of chemically modified proteins to study the effect of a single protein property on partitioning in aqueous two-phase systems: Effect of surface charge

Osteopontin-Targeted and PPARδ-Agonist-Loaded Nanoparticles Efficiently Reduce Atherosclerosis in Apolipoprotein E–/– Mice

“…Nanotechnology provides new opportunities and advanced strategies for the diagnosis and treatment of a variety of diseases including infectious diseases, malignancies, and cardiovascular pathologies. 43 , 44 In the previous work, due to the overexpression of OPN in activated VSMCs, compared with small molecules, the ICG/SRT@HSA-pept NMs we formulated has the functional advantage of targeting drug delivery to plaques, so the therapeutic effect is more significant. 45 In this study, we designed and constructed targeted nanoparticles combined with PPARδ receptor agonist (GW1516@NP-OPN) that demonstrated effective inhibition of migration and apoptosis in ox-LDL-induced smooth muscle cells.…”

Thermodynamic modelling of phase equilibrium for water + poly(Ethylene glycol) + salt aqueous two-phase systems

“…It is possible to have an extremely selective separation of substances using aqueous two-phase systems; they provide a gentle and protective environment for biological material, since both phases are composed primarily of water (Albertsson, 1986). Aqueous twophase systems of the polymer-salt type have several advantages over the polymer-polymer type: the larger relative size of the drops, larger differences in density, greater selectivity, lower viscosity and lower cost; besides, it is more difficult to use systems with two polymers on an industrial scale due to high viscosity and high cost (Franco et al, 1996). However, the thermodynamic behavior of polymersalt systems is more complicated, due to the size differences between the smaller molecules and the polymer.…”