Use of Cerebral Blood Flow Measurements in the Prediction of Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage

Pickard, J. D.; Read, D. H.; Lovick, A. H. J.

doi:10.1007/978-3-642-70054-5_23

Cited by 3 publications

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“…Quantification of regional cerebral blood flow (rCBF) plays an important role in the diagnosis of various cerebrovascular and neurological disorders, among which are stroke, dementia, epilepsy, and psychiatric diseases . The introduction of the 99m Tc complex of hexamethylpropylene amine oxime (HM-PAO) in the late 1980s provided the first 99m Tc-based radiopharmaceutical that can be successfully used in the clinic for the assessment of brain perfusion .…”

Section: Introductionmentioning

confidence: 99%

Glutathione-Mediated Metabolism of Technetium-99m SNS/S Mixed Ligand Complexes: A Proposed Mechanism of Brain Retention

et al. 1999

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Two series of [99mTc](SNS/S) mixed ligand complexes each carrying the N-diethylaminoethyl or the N-ethyl-substituted bis(2-mercaptoethyl)amine ligand (SNS) are produced at tracer level using tin chloride as reductant and glucoheptonate as transfer ligand. The identity of [99mTc](SNS/S) complexes is established by high-performance liquid chromatographic (HPLC) comparison with authentic rhenium samples. The para substituent R on the phenylthiolate coligand (S) ranges from electron-donating (-NH2) to electron-withdrawing (-NO2) groups, to study complex stability against nucleophiles as a result of N- and R-substitution. The relative resistance of [99mTc](SNS/S) complexes against nucleophilic attack of glutathione (GSH), a native nucleophilic thiol of 2 mM intracerebral concentration, is investigated in vitro by HPLC. The reaction of [99mTc](SNS/S) complexes with GSH is reversible and advances via substitution of the monothiolate ligand by GS- and concomitant formation of the hydrophilic [99mTc](SNS/GS) daughter compound. The N-diethylaminoethyl complexes are found to be more reactive against GSH as compared to the N-ethyl ones. Complex reactivity as a result of R-substitution follows the sequence -NO2 >> -H > -NH2. These in vitro findings correlate well with in vivo distribution data in mice. Thus, brain retention parallels complex susceptibility to GSH attack. Furthermore, isolation of the hydrophilic [99mTc](SNS/GS) metabolite from biological fluids and brain homogenates provides additional evidence that the brain retention mechanism of [99mTc](SNS/S) complexes is GSH-mediated.

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Section: Introductionmentioning

confidence: 99%

Glutathione-Mediated Metabolism of Technetium-99m SNS/S Mixed Ligand Complexes: A Proposed Mechanism of Brain Retention

et al. 1999

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The hyperaemic response to a transient reduction in cerebral perfusion pressure

et al. 1992

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A mathematical model of cerebral blood flow and the cerebrospinal fluid circulation is described which permits the study of phenomena caused by dynamic changes in cerebrovascular autoregulatory or cerebrospinal fluid compensatory reserves. A transient decrease in cerebral perfusion pressure was produced by carotid artery compression. Comparison of the computer simulations with clinical and experimental data, reported elsewhere, suggests that the transient hyperaemic response (THR) is proportional to the strength of the autoregulatory response. The relationships between the magnitude and time course of the THR, and the period and level of reduction in CPP were studied. This model suggests that simple clinical tests based on the examination of THR using transcranial Doppler velocity measurements are of potential value for the non-invasive assessment of the autoregulatory reserve.

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A Modification of the Method for the Measurement of Cerebral Blood Flow Using [¹⁴C]Iodoantipyrine in Small Animals

Richards

Lovick

Pickard

1987

J Cereb Blood Flow Metab

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Use of Cerebral Blood Flow Measurements in the Prediction of Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage

Cited by 3 publications

References 7 publications

Glutathione-Mediated Metabolism of Technetium-99m SNS/S Mixed Ligand Complexes: A Proposed Mechanism of Brain Retention

Glutathione-Mediated Metabolism of Technetium-99m SNS/S Mixed Ligand Complexes: A Proposed Mechanism of Brain Retention

The hyperaemic response to a transient reduction in cerebral perfusion pressure

A Modification of the Method for the Measurement of Cerebral Blood Flow Using [¹⁴C]Iodoantipyrine in Small Animals

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Use of Cerebral Blood Flow Measurements in the Prediction of Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage

Cited by 3 publications

References 7 publications

Glutathione-Mediated Metabolism of Technetium-99m SNS/S Mixed Ligand Complexes: A Proposed Mechanism of Brain Retention

Glutathione-Mediated Metabolism of Technetium-99m SNS/S Mixed Ligand Complexes: A Proposed Mechanism of Brain Retention

The hyperaemic response to a transient reduction in cerebral perfusion pressure

A Modification of the Method for the Measurement of Cerebral Blood Flow Using [14C]Iodoantipyrine in Small Animals

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A Modification of the Method for the Measurement of Cerebral Blood Flow Using [¹⁴C]Iodoantipyrine in Small Animals