Use of Candida rugosa lipase as a biocatalyst for L-lactide ring-opening polymerization and polylactic acid production

Rahmayetty,; Whulanza, Yudan; Sukirno,; Rahman, Siti Fauziyah; Suyono, Eko Agus; Yohda, Masafumi; Gozan, Misri

doi:10.1016/j.bcab.2018.09.015

Cited by 34 publications

(15 citation statements)

References 38 publications

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“…The 1 H NMR spectrum of PLA at 2.6 and 4.37 ppm was assigned to the methine proton next to the terminal hydroxyl group and carboxyl group, respectively. The result from analysed of 1 H NMR, the spectrum of PLA was similar to that reported by other works [3,13]. Figure 3(b) shows the 13 C NMR spectrum of PLA product.…”

Section: Molecular Structure Of Plasupporting

confidence: 87%

“…PLA is one of the most appropriate polymers to replace non-biodegradable synthetic polymers based on fossil fuel [2]. Polylactic acid (PLA) is a highly versatile material, which can be obtained from the renewable resources such as garbage, potato, sugars in corn starch, cassava or sugar cane and glycerin waste of biodiesel and other agricultural products [3]. PLA is widely used for various applications, in the medical field using as tissue engineering, implants, drug delivery systems etc.…”

Section: Introductionmentioning

confidence: 99%

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Effect of temperature and time for the production of polylactic acid without initiator catalyst from lactide synthesized from ZnO powder catalyst

Nyiavuevang

Sodkampang

Dokmaikun

et al. 2022

J. Phys.: Conf. Ser.

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Polylactic acid (PLA) is a biodegradable polymer that most importance at the present due primarily to its properties as biological degradation and biocompatibility derived from renewable resources. This study investigated the role of zinc oxide powder and tin(II) 2-ethylhexanoate as the catalysts for lactide and PLA synthesis, respectively. Polylactic acid was obtained by four stages: dehydration, oligomerization, depolymerization and ring opening polymerization. The catalyst was added and water was removed at the first stage then the reactions are carried out at different temperatures and reaction time on the other stages. The ratio of lactic acid and zinc oxide powder was 1000:3 for lactide synthesis, the ratio of lactide product and tin(II) 2-ethylhexanoate was 1000:4 for PLA synthesis without any initiator. The PLA products were analysed for the yield, some chemical and physical properties such as functional group, decomposition temperature, melting temperature of synthesized PLA. It is found that at reaction temperature of 160°C and reaction time for 5 h gave the highest yield PLA of 64.5% with its decomposition temperature of 311°C and melting point temperature at 152°C. There are two main mechanisms, polymerization and depolymerisation occurring in reaction and each mechanism plays a major role with respect to the reaction condition. At higher reaction temperature and longer time, the rate of depolymerisation is higher than that of polymerization leading to the lower of decomposition and melting temperature of synthesized PLA.

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Section: Molecular Structure Of Plasupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Effect of temperature and time for the production of polylactic acid without initiator catalyst from lactide synthesized from ZnO powder catalyst

Nyiavuevang

Sodkampang

Dokmaikun

et al. 2022

J. Phys.: Conf. Ser.

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“…The biocompatibility with human bodies includes nontoxicity, biodegradability, and bioactivity/bio-inertness. Biodegradable polymers, especially polyesters, have been shown to serve this purpose relatively well and many types of research have been done on biopolyesters-based materials intended for bioimplant [8] [9]. However, pure polyesters are hydrophobic and tend to have poor cell-adhesion [9] [10].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Study of Potential Bioimplant from Glycerol Plasticized Starch-Microcrystalline Cellulose Composite

Rineksa

Whulanza

Gozan

2021

JIAE

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Biodegradable and bio-based substitutes for conventional plastics are on the rise in these past decades. One of the applications of bioplastic is for biomedical implants or bioimplant. Starch was plasticized using glycerol at varying amounts (40% and 60% of dry starch mass) to produce thermoplastic starch (TPS). A reinforcement filler of microcrystalline cellulose (MCC) was used to improve the mechanical properties. The MCC content in this study was also varied (0%, 2%, 4%, and 8% w/w). This paper studies the mechanical properties of starch-MCC composites for their potential as bioimplant. The optimum glycerol and MCC contents from the results are 40% glycerol and 8% MCC with 2.97 MPa tensile strength and 7.20% strain at break. Thus, the sample has the potential application in bioimplant material for trabecular bone replacement, which has an average tensile strength of 2 MPa and strains at a break of 2.5%.

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“…The sample of reaction was taken for 3 hours. The temperature used for polymerization process was followed from [9] which was between 110℃ to 130℃.…”

Section: Pla Production Processmentioning

confidence: 99%

Polymerization of Lactide to Polylactic Acid by using Homogenous and Heterogenous Catalysts

Ibrahim*,

Mohamed

2019

IJRTE

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Replacing non-biodegradable to degradable polymers are very much in concern due to reduction of petroleum supply, environment and economical related to waste disposal. Polylactic acid (PLA) shows a promising alternative to produce biodegradable plastic. The polymerization happened in homogenous phase where the catalyst, mostly used tin octoate, and the lactide are mixed in liquid phase to form PLA. However, this method become problematic for the product because the catalysts remain with the PLA and the degradation of catalyst occurred. Therefore, this study aims to convert the homogeneous catalyst to heterogeneous using ceramic waste as the support and to characterize the PLA produced by using Ultraviolet Visible (UV-Vis) Spectrometer and Fourier Transform Infrared Spectroscopy (FTIR). The experiment was carried out at different temperatures which were 110℃, 120℃ and 130℃. From the results obtained, the highest concentration of PLA produced is at temperature of 130℃ by using heterogenous catalyst. Therefore, it can be concluded that heterogeneous catalyst can be a new method of producing PLA.

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Use of Candida rugosa lipase as a biocatalyst for L-lactide ring-opening polymerization and polylactic acid production

Cited by 34 publications

References 38 publications

Effect of temperature and time for the production of polylactic acid without initiator catalyst from lactide synthesized from ZnO powder catalyst

Effect of temperature and time for the production of polylactic acid without initiator catalyst from lactide synthesized from ZnO powder catalyst

Preliminary Study of Potential Bioimplant from Glycerol Plasticized Starch-Microcrystalline Cellulose Composite

Polymerization of Lactide to Polylactic Acid by using Homogenous and Heterogenous Catalysts

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