Use of bioresorbable membrane (sodium hyaluronate + carboxymethylcellulose) after controlled bowel injuries in a rabbit model

Moreira, Hélio; Wexner, Steven D.; Yamaguchi, Takuya; Pikarsky, Alon J.; Choi, Jeong Seok; Weiss, Eric G.; Nogueras, Juan J.; Sardinha, T. Cristina; Billotti, V. Lee

doi:10.1007/bf02236979

Cited by 49 publications

(42 citation statements)

References 6 publications

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“…Following open gynecological interventions, this ratio may increase up to 97%. [1][2][3][4][5][6][7] The postoperative adhesions are an important problem for surgeons at reoperation owing to the increased access time into the abdominal cavity, difficulties during exploration and injuries to the adjacent organs. In 1998 in the United States, the cost of treatment for preventing formation of adhesions and complications was 1.6 billion dollars.…”

Section: Resultsmentioning

confidence: 99%

Prevention Of adhesion To prosthetic mesh: Comparison Of Oxidized Generated Cellulose, Polyethylenglycol And Hyalen GF 20 (An Experimental Study)

Altınlı¹

2011

Ulus Travma Acil Cerrahi Derg

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Section: Resultsmentioning

confidence: 99%

Prevention Of adhesion To prosthetic mesh: Comparison Of Oxidized Generated Cellulose, Polyethylenglycol And Hyalen GF 20 (An Experimental Study)

Altınlı¹

2011

Ulus Travma Acil Cerrahi Derg

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“…Hence, in order to minimize PI, several techniques have been developed in the field of abdominal surgery. Among them, an adhesion barrier film is frequently used for preventing adhesional ileus (31,32). In fact, in this meta-analysis, an adhesion barrier film was used in about 80% of patients in one study (total gastrectomy for gastric cancer) (24) and in about 50% of patients in two studies (open colectomy for colon cancer and PD for periampullary tumor or tumor of the pancreas head) (21,30).…”

Section: Discussionmentioning

confidence: 96%

Perioperative Administration of Traditional Japanese Herbal Medicine Daikenchuto Relieves Postoperative Ileus in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis

Ishizuka

Shibuya

Nagata

et al. 2017

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Abstract. Aim: Although it has been widely demonstrated that administration of Daikenchuto (DKT), a traditional Japanese herbal medicine, improves gastrointestinal (GI) motility in patients undergoing abdominal surgery, few studies have investigated the efficacy of perioperative DKT administration for relief of postoperative ileus (PI) in patients undergoingDaikenchuto (DKT) is a well-known traditional Japanese herbal (kampo) medicine for improvement of gastrointestinal (GI) function (1-4). DKT extract powder is manufactured from an aqueous extract containing 2.2% Japanese pepper, 5.6% processed ginger, 3.3% ginseng radix, and 88.9% maltose syrup powder derived from rice (Tsumura & Co., Tokyo, Japan) (3). Because the medicinal effects of DKT have been established through a delicate balance of these three herbal ingredients over many centuries, DKT has not yet been fully accepted by all modern physicians, including those in both eastern (5) and western countries.However, over the past decade, basic studies using animal models have revealed that the effects of DKT on GI function are mediated by cholinergic and serotonergic nerves (6). Several studies have demonstrated that DKT enhances GI motility both in vitro (7,8) and in vivo (6, 9, 10), as well as increasing intestinal blood flow (2, 11), reducing the blood ammonia level after hepatectomy (12), and exerting anti-inflammatory effects (13,14). Similarly, recent clinical studies have demonstrated that DKT improves not only GI motility after surgery (15, 16) but also attenuates the progression of adhesional bowel obstruction due to abdominal surgery (17,18).Although several randomized controlled trials (RCTs) have confirmed the effects of DKT (19), previously demonstrated in animal models (13,20), for improving postoperative GI motility in patients undergoing abdominal surgery (21-25), few studies have investigated whether DKT reduces the occurrence of postoperative ileus (PI) in patients undergoing surgery for GI cancer as a primary end-point. Therefore, it seems reasonable to assume that, if DKT 5967

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“…Various clinical and experimental studies have been attempted to reduce IA formation by using different systemic and local drugs and mechanical barriers [5,16]. Numerous substances such as steroids, nonsteroidal anti-inflammatory drugs, anticoagulants, and TPA have been used in prevention and treatment of IA with limited success [4].…”

Section: Discussionmentioning

confidence: 99%

“…Numerous substances such as steroids, nonsteroidal anti-inflammatory drugs, anticoagulants, and TPA have been used in prevention and treatment of IA with limited success [4]. Physical barriers may also be applied including Dermofilm Ò which is composed of glycan, propylene glycol, stearine [5], and Seprafilm Ò composed of sodium hyalunaric acid and carboxymethyl cellulose [14,16]. IA formation is a multifactorial process and many etiologies may be suggested such as injury to peritoneum or intestine, foreign bodies (such as talcum powder from surgical gloves), and infection [5,6,[17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Antiadhesive effects of mitomycin C and streptopeptidase A in rats with intraperitoneal adhesions

et al. 2007

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Intraabdominal adhesion formation is a frequent problem after major abdominal surgery. For many years, there have been various attempts to decrease adhesions by using systemic and local drugs and mechanical barriers. In this study we aimed to evaluate the antifibrinolytic antiadhesive effects of mitomycin C (MMC) and streptopeptidase A (SA) against intraabdominal adhesions. Forty-eight rats were divided into six groups, each with eight rats. Group 1 (sham group) rats were laparotomized by transverse incision only. In Group 2 (laparotomy and talcum powder), 2 ml talcum powder was scattered equally onto the intestinal surface after laparotomy. Group 3 (SA only), 2 g SA was introduced onto the intestinal surface. Group 4 (talcum powder and SA), 2 ml talcum powder was scattered onto the intestinal surface and then 2 g SA was applied on the same area. Group 5 (MMC only), 2 ml MMC was introduced onto the intestinal surface. Group 6 (talcum powder and MMC), 2 ml talcum powder was scattered onto intestinal surface and then MMC was applied onto same area. We assessed adhesion grades macroscopically, as well as, hydroxproline levels biochemically. Macroscopicaly, the number of rats with moderate or severe adhesions was significantly higher in the control group than all other groups (P < 0.05). SA and MMC groups had only mild adhesions. No intraabdominal problem was detected in rats with SA or MMC. Hydroxyproline (HP) levels were significantly higher in control group than all other groups (P < 0.05). There was no statistical significance between the rats with SA and MMC (P > 0.05) according to the HP measurements. MMC and SA may have potential antiadhesive effects. Both substances could be beneficial against adhesion formation after laparotomies.

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Use of bioresorbable membrane (sodium hyaluronate + carboxymethylcellulose) after controlled bowel injuries in a rabbit model

Abstract: The use of Seprafilm at the sites of myotomies significantly reduced the incidence of adhesions. Effectiveness at the enterotomy site may have been attenuated by a greater inflammatory response. Importantly, Seprafilm did not increase septic mortality in any group.

Cited by 49 publications

References 6 publications

Prevention Of adhesion To prosthetic mesh: Comparison Of Oxidized Generated Cellulose, Polyethylenglycol And Hyalen GF 20 (An Experimental Study)

Prevention Of adhesion To prosthetic mesh: Comparison Of Oxidized Generated Cellulose, Polyethylenglycol And Hyalen GF 20 (An Experimental Study)

Perioperative Administration of Traditional Japanese Herbal Medicine Daikenchuto Relieves Postoperative Ileus in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis

Antiadhesive effects of mitomycin C and streptopeptidase A in rats with intraperitoneal adhesions

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