Use of Berberine in Treatment of Giardiasis

Gupte, Suraj

doi:10.1001/archpedi.1975.02120440082020

Cited by 16 publications

(11 citation statements)

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“…It has been reported to inhibit the secretory responses of heat-labile enterotoxins of E. coli and V. cholera in rabbit ligated intestinal loop model [49]. Orally administered berberine resulted in more effective elimination of parasites than other established drugs [51].…”

Section: Antimicrobial Activities Of Genusmentioning

confidence: 99%

Phytopharmacological and ethnomedicinal uses of the Genus Berberis (Berberidaceae): A review

Khan¹,

Najeebullah²,

Ali³

et al. 2016

Trop. J. Pharm Res

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Section: Antimicrobial Activities Of Genusmentioning

confidence: 99%

Phytopharmacological and ethnomedicinal uses of the Genus Berberis (Berberidaceae): A review

Khan¹,

Najeebullah²,

Ali³

et al. 2016

Trop. J. Pharm Res

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“…In India and China, berberine is used as a remedy for diarrhea, respiratory infection, constipation, indigestion, and cardiac arrhythmia. It is also used in antipyretic preparations and as an antimalarial and giardia treatment (Chopra et al, 1932; Choudry et al, 1972; Gupta, 1975; Sabir et al, 1976; Purohit et al, 1982; Ghosh et al, 1983; Sun et al, 1988; Huang, 1990; Vennerstrom et al, 1990; Newall et al, 1996; Schmeller et al, 1997; Birdsall and Kelly, 1998; Merck, 1998). High doses of berberine of approximately 5–60 mg/kg body weight are used in diarrhea treatment (Rabbani et al, 1987; Bergner, 1997b).…”

Section: Introductionmentioning

confidence: 99%

Developmental toxicity evaluation of berberine in rats and mice

Jahnke

Price

Marr

et al. 2006

Birth Defects Research Pt B

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In rats, maternal, but not fetal adverse effects were noted. The maternal toxicity LOAEL remained at 7,250 ppm (531 mg/kg/day) based on the feed study and the developmental toxicity NOAEL was raised to 1,000 mg/kg/day BCD based on the gavage study. In the mouse, 33% of the treated females died. Surviving animals had increased relative water intake, and average fetal body weight per litter decreased 5-6% with no change in live litter size. The maternal toxicity LOAEL remained at 5,250 ppm (841 mg/kg/day) BCD, based on increased water consumption. The developmental toxicity LOAEL was raised to 1,000 mg/kg/day BCD based on decreased fetal body weight.

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“…Equation 4: Mean diarrhoeal stools from patients in tetracycline group (7-1 1)-mean diarrhoeal stools from patients in tetracycline and Equation 1: Mean diarrhoeal stools from patients in placebo group 1 berberine group (6 2 1)=antisecretory effect of berberine (0 9 1). (9-2 I)-mean diarrhoeal stools from patients in berberine alone group Equation 5: Vibriostatic effect of tetracycline and antisecretory (8-2 1)=presumed antisecretory and vibriostatic effects of berberine effect of berberine from equation 3 (3 1 or 2-8 1)-vibriostatic effect of (11). tetracycline from equation 2 (1-9 1)=antisecretory effect of berberine Equation 2: Mean diarrhoeal stools from patients in placebo group 2…”

Section: Resultsmentioning

confidence: 99%

Clinical trial of berberine in acute watery diarrhoea.

Khin‐Maung‐U¹,

Myo-Khin²,

Nyunt-Nyunt-Wai³

et al. 1985

BMJ

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Four hundred adults presenting with acute watery diarrhoea were entered into a randomised, placebo controlled, double blind clinical trial of berberine, tetracycline, and tetracycline and berberine to study the antisecretory and vibriostatic effects of berberine. Of 185 patients with cholera, those given tetracycline or tetracycline and berberine had considerably reduced volume and frequency of diarrhoeal stools, duration of diarrhoea, and volumes of required intravenous and oral rehydration fluid. Berberine did not produce an antisecretory effect. Analysis by factorial design equations, however, showed a reduction in diarrhoeal stools by one litre and a reduction in cyclic adenosine monophosphate concentrations in stools by 77% in the groups given berberine. Considerably fewer patients given tetracycline or tetracycline and berberine excreted vibrios in stools after 24 hours than those given berberine alone. Neither tetracycline nor berberine had any benefit over placebo in 215 patients with noncholera diarrhoea. IntroductionTo reduce the need for treatment with oral and intravenous fluid in patients with severe diarrhoea due to cholera and similar bacterial enteric infections, agents that reverse the stimulation of secretion of water and electrolytes by cholera toxin and the related toxins of enterotoxigenic Escherichia coli are sought.' Berberine is an alkaloid derived from the roots and bark of the plant Berberis aristata: a spiny, deciduous, evergreen shrub with yellow flowers (berberry bush). Berberine has a broad spectrum antibiotic activity against selective bacteria,2 including Vibrio cholerae, shigella, pseudomonas, E coli, proteus, protozoa such as Entamoeba histolytica,3 trichomonas,4 giardia,5 leishmania,6 and fungi. Extracts of this plant have been used in antidiarrhoeal medication in Ayurvedic medicine in India and in the traditional medicine of China for the past 3000 years. More recently berberine has been shown to inhibit the action of V cholerae toxin when administered before or with the enterotoxin in animals,8 "to have an antisecretory effect in the ligated intestinal loop of the rabbit even when administered after the enterotoxin has been bound to intestinal mucosa,'2 and also to inhibit the secretory response of E coli ST (heat stable) toxin in the infant mouse. 12Few clinical trials of berberine to date have shown it to be effective in treating acute diarrhoea.'3"'9 No clinical trial studying the antisecretory effect of berberine in diarrhoea has been reported. This report concerns a randomised, double blind, placebo controlled clinical trial of berberine v tetracycline v berberine and tetracycline to study the antisecretory effect and clearance of vibrios from stools in patients with cholera. Patients and methodsAdults admitted to the Infectious Diseases Hospital with a history of watery diarrhoea less than 48 hours before admission and no history of antibiotic ingestion, coexisting illness such as pneumonia, systemic illness such as diabetes or hypertension, or diarrhoea within ...

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Use of Berberine in Treatment of Giardiasis

Cited by 16 publications

References 0 publications

Phytopharmacological and ethnomedicinal uses of the Genus Berberis (Berberidaceae): A review

Phytopharmacological and ethnomedicinal uses of the Genus Berberis (Berberidaceae): A review

Developmental toxicity evaluation of berberine in rats and mice

Clinical trial of berberine in acute watery diarrhoea.

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