Developmental toxicity evaluation of berberine in rats and mice

Jahnke, Gloria D.; Price, Catherine J.; Marr, Melissa C.; Myers, Christina; George, Julia D.

doi:10.1002/bdrb.20075

Cited by 67 publications

(33 citation statements)

References 24 publications

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“…Group two was treated with Praziquantel (PZQ) at 500 mg/Kg via 70% glycerine on two successive days. Group three were gavaged with 100 μl of 12 mg/kg berberine chloride (one-third of the 50% lethal dose) (Sigma, St. Louis, MO, USA) [31] for 10 days. Groups four, five and six were infected with 100 ± 10 S. mansoni cercariae.…”

Section: Methodsmentioning

confidence: 99%

Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice

Dkhil

2014

biol res

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BackgroundSchistosomiasis is caused by helminth parasites of the genus Schistosoma. Berberine chloride (BER), an isoquinoline alkaloid, has been used in vivo for its antiparasitic, antioxidant and hepatoprotective properties. In this study, the protective effect of BER and praziquantel has been compared for the extent of schistosomiasis-induced oxidative stress in hepatic tissue of mice.ResultsS. mansoni was able to induce inflammation and injury to the liver, evidenced (i) by an increase in inflammatory cellular infiltrations, dilated sinusoids and vacuolated hepatocytes, (ii) by decreased levels of alanine and aspartate aminotransferases and increased levels of alkaline phosphatase, γ-glutamyl transferase in the liver homogenate, (iii) by increased production of nitric oxide and thiobarbituric acid reactive substances, and (iv) by lowered glutathione levels and decreased activities of catalase and superoxide dismutase, respectively. All these infection-induced parameters were significantly altered during BER treatment. In particular, berberine counteracted the S. mansoni-induced loss of glutathione and the activities of catalase and superoxide dismutase.ConclusionBased on these results, it is concluded that berberine could ameliorate pre-existing liver damage and oxidative stress conditions due to schistosomiasis.

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Section: Methodsmentioning

confidence: 99%

Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice

Dkhil

2014

biol res

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“…administration to mice and rats were found to be 30 mg/kg and 205 mg/kg, respectively, allowing mice to be approximately six-fold more sensitive to toxicity from berberine (Registry of the Toxic Effects of Chemical Substances, 2008). Berberine chloride dihydrate (BCD) was evaluated for developmental toxicity in rats and mice (Jahnke et al, 2006). In this study, there were no maternal deaths, however, adverse effects were noted in maternal rat, but not in fetus.…”

Section: Berberinementioning

confidence: 97%

Berberine and Coptidis Rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations

Tang

Feng

Tsao

et al. 2009

Journal of Ethnopharmacology

442

306

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The modern evidences of treating cancer with huanglian and berberine have a strong linkage with traditional concept and rules of using huanglian in CM practice. As anticancer candidates with low toxicity, berberine and its altered structure, as well as huanglian and its formulae, will attract scientists to pursue the potential anticancer effects and the mechanisms by using technologies of genomics, proteomics and other advanced approaches. On the other hand, relatively few in vivo studies have been conducted on anticancer effects of huanglian and berberine. The clinical application of berberine or huanglian as novel cancer therapeutic agents requires in vivo validations and further investigations of their anticancer mechanisms.

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“…The other constituents of RC including coptisine, palmatine and epiberberine were also reported to present some pharmacological effects such as antispasmodic and relaxant activity (Hiller et al, 1998), inhibition of West Nile virus (Jia et al, 2010). Most previous studies have only focused on the cytotoxicity of berberine, coptisine and the total extract of RC (Colombo et al, 2001;Ma et al, 2010), and the acute toxicity- (Kheir et al, 2010), developmental toxicity (Jahnke et al, 2006) as well as genotoxicity (Pasqual et al, 1993) of berberine. However, little attention has been given to investigate the sub-chronic toxicity of RC main alkaloids (berberine, coptisine, palmatine and epiberberine) and RC and little information is available concerning the possible histopathological changes in rats by oral administration of RC alkaloids and RC for 90 days.…”

Section: Activitiesmentioning

confidence: 99%