Use of aqueous benzathine penicillin G in the treatment of syphilis in pregnant women

Syphilis in adults

“…66 There are controversies surrounding treatments of pregnant women with a single dose of benzathine penicillin as failures has been reported. [67][68][69] Although a single dose may be effective, 70 71 some prefer to treat pregnant women with two to three doses of benzathine penicillin at weekly intervals. 68 In one study treatment of pregnant women using a single dose benzathine penicillin improved pregnancy outcome but the risk of adverse outcome remained high when compared with uninfected mothers, 31 but these result were not found in another study.…”

Congenital Syphilis in the Newborn

“…A newborn with a sérologie titer fourfold or more higher than that of the mother regardless of the his-tory of treatment of the mother should be treated. 4. A newborn with a reactive sérologie test for syph¬ ilis, and whose mother, in the judgment of the pbysician, was inadequately treated or untreated during or before pregnancy, should be treated.…”