Use of Antilymphocyte Globulin Prepared by Precipitation with Rivanol® and Reduced Dose of Azathioprine in Allogenic Renal Transplantation in the Dog

Weiber, A; Husberg, B; Carlsson, Stefan; Liedberg, Carl-Fredrik; Linell, F; Nettelblad, Sven-Caspar

doi:10.3109/00365596909135414

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…ALIg-G had a slight anemia-producing effect but less than that reported earlier (Weiber et al, 1969). I n the present study, where ALIg-G was given in the postoperative period, it had no significant effect on the number of lymphocytes in the blood or on the platelet or granulocyte counts.…”

Section: Laboratory Studiescontrasting

confidence: 81%

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Antilymphocyte Globulin Prepared by Precipitation with Rivanol in the Treatment of Acute Rejection Following Allogenic Renal Transplantation in the Dog

Husberg

Carlsson

Hellsten

et al. 1972

Scandinavian Journal of Urology and Nephrology

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Horse-antidog antilymphocyte immunoglobulin-G (ALIg-G) was prepared by precipitation with 2-ethoxy-6,9-diamino-acridine lactate (Rivanola). Twenty dogs received azathioprine in a small daily dose after allogenic renal transplantation. ALIg-G treatment was started as soon as a rejection crisis was suspected. Ten dogs receiving no other immunosuppressive therapy were given ALIg-G from the 4th day after allogenic renal transplantation. It appears that ALIg-G treatment may influence early acute rejection in the dog. Scand J Urol Nephrol6Scand J Urol Nephrol Downloaded from informahealthcare.com by Monash University on 02/04/15For personal use only.

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Section: Laboratory Studiescontrasting

confidence: 81%

“…The preparation has been described earlier by Weiber et al, 1969. A horse was given injections of dog spleen cells subcutaneously and intramuscularly. ALIg-G from the horse serum was prepared by precipitation first with Rivanola and then with ammonium sulphate.…”

Section: Preparation and Testing Of Allg-gmentioning

confidence: 99%

Antilymphocyte Globulin Prepared by Precipitation with Rivanol in the Treatment of Acute Rejection Following Allogenic Renal Transplantation in the Dog

Husberg

Carlsson

Hellsten

et al. 1972

Scandinavian Journal of Urology and Nephrology

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“…On incubation of ALG with dog serum in concentrations from 1/10 to 10/1, no precipitates were produced. This preparation has proven immunosuppressive properties [51].…”

Section: In Vitro Experimentsmentioning

confidence: 99%

The Possible Role of Vasoactive Substances for the Hemodynamic Effects of Rapidly Injected Antilymphocyte Globulin

Henricsson¹,

Bergentz²

1977

Eur Surg Res

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A rapid intravenous injection of ALG into splenectomized dogs induced an almost complete elimination of lymphocytes and an extensive but partly reversible thrombocytopenia during which platelets were trapped in the lung. During this trapping there was a significant decrease in arterial blood pressure, pulmonary blood volume and cardiac output concomitant with a marked increase in the portal pressure. The pulmonary arterial pressure remained unchanged. The hemodynamic effects are probably caused by a release of vasoactive substances which induced a decreased venous return from splanchnic pooling and stasis. Prostaglandins and histamine seem to play a dominant role, since Aspirin, promethazine and 48/80 markedly reduced the side-effects.

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“…Furthermore, ferroptosis was also reported to play critical roles in anti-tumor immunity by regulating T cell function and in modulating the efficacy of tumor immunotherapy (16). Therefore, ferroptosis attracts increasing interest in understanding its potential roles in cancer therapy due to the specific tumor suppressive signaling pathways and the feasibility of the development of ferroptosis-inducing drugs (17,18). In this review, we summarized and discussed the potential roles of ferroptosis in regulating antitumor immunity, tumor microenvironment (TME) and the improvement of therapeutic efficacy of immunotherapy in cancers.…”

Section: Introductionmentioning

confidence: 99%

Deciphering the potential roles of ferroptosis in regulating tumor immunity and tumor immunotherapy

Liu

Dai

et al. 2023

Front. Immunol.

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Cancer immunotherapies, including immune checkpoint inhibition (ICI) and adoptive immune cells therapy, are promising therapeutic strategies. They reactivate the function of immune cells and induce immune responses to attack tumor cells. Although these novel therapies benefited a large amount of cancer patients, many cancer patients have shown fair responses even resistance to cancer immunotherapies, limiting their wide clinical application. Therefore, it is urgent to explore the underlying mechanisms of low response and resistance of cancer immunotherapy to enhance their treatment efficacy. The programmed cell death (PCD) including the ferroptosis, has been demonstrated to play essential roles in antitumor immunity and in regulating the immune response to ICIs. Ferroptosis, a phospholipid peroxidation-mediated, iron-dependent membrane damage, exhibite three critical hallmarks: the oxidation of phospholipids, the lack of lipid peroxide repair capability and the overloading of redox-active iron. Notably, ferroptosis was found to plays important roles in regulating tumor immunity and response to immunotherapy. Therefore, targeting ferroptosis alone or in combination with immunotherapy may provide novel options to promote their antitumor efficacy. However, the effect of ferroptosis on tumor immunity and immunotherapy is affected by the interaction of ferroptosis and cancer cells, immune cells, tumor microenvironment (TME) and others. In this review, we summarized and discussed the critical roles of ferroptosis in regulating antitumor immunity, TME and in the improvement of the therapeutic efficacy of immunotherapy in cancers.

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Use of Antilymphocyte Globulin Prepared by Precipitation with Rivanol® and Reduced Dose of Azathioprine in Allogenic Renal Transplantation in the Dog

Cited by 5 publications

References 5 publications

Antilymphocyte Globulin Prepared by Precipitation with Rivanol in the Treatment of Acute Rejection Following Allogenic Renal Transplantation in the Dog

Antilymphocyte Globulin Prepared by Precipitation with Rivanol in the Treatment of Acute Rejection Following Allogenic Renal Transplantation in the Dog

The Possible Role of Vasoactive Substances for the Hemodynamic Effects of Rapidly Injected Antilymphocyte Globulin

Deciphering the potential roles of ferroptosis in regulating tumor immunity and tumor immunotherapy

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