Use of Antidiabetic, Antihypertensive, and Psychotropic Drugs in Pregnancy

Fasanella, Dana R.; Luttrell, Sarah; Tejada, Frederick R.; Ngokobi, Harris; Ayuk-Tabe, Manyo

doi:10.1016/bs.seda.2018.07.005

Cited by 4 publications

(2 citation statements)

References 91 publications

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“…Many studies have been conducted related to the use of oral antidiabetic drugs. [3][4][5] Therefore, many people choose to use traditional medicine that is accepted to be safer, affordable, and effective. 6,7 Mountain papaya (Vasconcellea pubescens A.DC.)…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

Sasongko¹,

Lestari²,

Yugatama³

et al. 2020

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Introduction: Mountain papaya (Vasconcellea pubescens A.DC.) and bitter melon (Momordica charantia L.) fruit extract have total flavonoids and some metabolite from its contains. The use of a single dose in the treatment of diabetes is often considered to lack a strong effect. Giving a combination of the compound is a solution to provide a synergistic effect in treatment. Material and Methods: Rat were divided into eight groups (normal, negative control, glibenclamide as a positive control, and five dose extract group). The single dose mountain papaya extract (MPE) and bitter melon extract (BME) were given at 174 mg/kg b.w of MPE, and 380 mg/kg b.w of BME in oral administration.

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Section: Introductionmentioning

confidence: 99%

Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

Sasongko¹,

Lestari²,

Yugatama³

et al. 2020

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“…However, their association with minor or organ-specific congenital anomalies is less clear in the existing literature (Table 2). Certain studies (9,11,(14)(15)(16) suggest that an increase in cardiovascular malformations, cleft lip or palate and central nervous system malformations is present or cannot be excluded. J. E. H. Bergman et al (14), in a recent case-malformedcontrol study, found that there were significantly increased odds of multi-cystic renal dysplasia occurring after maternal exposure to combined alpha-and beta-blockers.…”

Section: β-Adrenergic Receptor Blocking Agentsmentioning

confidence: 99%

In Utero Exposure to Antihypertensive Medication during the First Trimester: Is the Risk Worth Taking?

Papadopoulou

Tsialiou

Styanidou

et al. 2022

ama

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The aim of this study is to evaluate and present the evidence so far, regarding fetal outcomes after in utero exposure to antihypertensive medication. Hypertensive disorders during pregnancy constitute a significant risk factor for maternal and fetal outcomes, necessitating antihypertensive treatment. However, current data concerning the safety of in utero exposure to antihypertensive medication are controversial. While some studies recommend the administration of certain agents, others underline the possible adverse effects on fetal development. This review aims to summarize the outcomes of studies published during the last decade, referring to first trimester in utero exposure to antihypertensive agents. In general, a-methyldopa, β-blockers and calcium channel blockers are the first or second treatment line for hypertension during pregnancy. However, ACEIs, ARBs and diuretics are mostly contraindicated, as the potential risk outweighs the benefits of their administration. Additionally, several drugs should be avoided, due to the lack of data regarding their safety.Conclusion. As current studies are restricted for ethical reasons, there is a significant lack of evidence concerning diverse antihypertensive agent use. In utero exposure to antihypertensive medication needs to be carefully evaluated and supported by further research.

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Adverse drug reactions and adverse drug events associated with use of psychotropic, antiepileptic, antihypertensive and antidiabetic drugs in pregnancy

Fasanella

Benner

Tejada

et al. 2019

Side Effects of Drugs Annual

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Use of Antidiabetic, Antihypertensive, and Psychotropic Drugs in Pregnancy

Cited by 4 publications

References 91 publications

Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

In Utero Exposure to Antihypertensive Medication during the First Trimester: Is the Risk Worth Taking?

Adverse drug reactions and adverse drug events associated with use of psychotropic, antiepileptic, antihypertensive and antidiabetic drugs in pregnancy

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