Use of antidepressants and risk of colorectal cancer: a nested case-control study

Xu, Wanning; Tamim, Hani; Shapiro, Stan; Stang, Mary Rose; Collet, Jean‐Paul

doi:10.1016/s1470-2045(06)70622-2

Cited by 121 publications

(128 citation statements)

References 40 publications

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“…A receptorindependent pathway (3) is the most likely mechanism. This might also offer an explanation for the reduction of human colorectal cancer incidence by SSRIs (16), as these reduce the uptake of serotonin into colonic enterocytes.…”

Section: Discussionmentioning

confidence: 98%

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Serotonin Regulates Macrophage-Mediated Angiogenesis in a Mouse Model of Colon Cancer Allografts

Nocito¹,

Dahm²,

Jochum

et al. 2008

Cancer Research

126

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Section: Discussionmentioning

confidence: 98%

“…Interestingly, a recent population-based study showed a high intake of selective serotonin reuptake inhibitors (SSRI) to correlate with a reduced incidence of colorectal cancer (16). This observation suggests a biological relevance of serotonin for colorectal cancer growth in vivo.…”

Section: Introductionmentioning

confidence: 99%

Serotonin Regulates Macrophage-Mediated Angiogenesis in a Mouse Model of Colon Cancer Allografts

Nocito¹,

Dahm²,

Jochum

et al. 2008

Cancer Research

126

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“…15 In a more recent study, the use of antidepressants was found to correlate with a positive outcome for patients with colon cancer. 16 However, the mechanism of how antidepressants suppress growth is not exactly clear. SAM is well-tolerated and has been shown to be free of any adverse effects in a human clinical trail involving patients with osteoarthritis.…”

mentioning

confidence: 99%

S‐adenosyl L‐methionine inhibits azoxymethane‐induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco‐2 cell growth in 3D culture

Guruswamy

Swamy

Choi

et al. 2007

Intl Journal of Cancer

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S-Adenosyl L-methionine (SAM) is a universal methyl group donor to various intermediary metabolites, hormones, proteins, neurotransmitters, phospholipids and nucleic acids. Deficiency of folate, which plays a role in the synthesis of SAM leads to increased risk for colon cancer. This study tested the effectiveness of SAM supplementation in protecting against azoxymethane (AOM)-induced colon carcinogenesis in male F344 rats. We also tested the effect of SAM on cyclooxygenase-2 (COX-2) in a macrophage cell line. Further, we developed a 3-D culture model using Caco-2 cells to test the effect of SAM on tumor spheroid size and number. Groups of rats were given the experimental diet containing either 0-, 400-or 800-ppm SAM, 1 week before the first AOM injection and continued until 8 weeks. In the control group, AOM produced a substantial number of aberrant crypt foci (ACF) (96 6 8). Dietary administration of SAM significantly reduced the number of total ACF (400 ppm SAM, 68 6 7.3, p < 0.01 and 800 ppm SAM, 57 6 7.1, p < 0.001). SAM significantly decreased AOM-induced colonic multicrypt foci in a dose-dependent manner. Suppression of Lipopolysaccharide (LPS) induced COX-2 protein expression was observed in a RAW264.7 cell line. We established growth of Caco-2 cells as spheroids, in a 3D matrix of collagen and matrigel. Treatment with SAM decreased both size and number of spheroids in a dose-dependent manner (p < 0.0001). These observations demonstrate for the first time that SAM can reduce the occurrence of ACF in AOM treated male F344 rats and suppress formation of human tumor spheroids and expression of COX-2. ' 2007 Wiley-Liss, Inc.

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“…Cell cycle progression is well controlled by the activation and inactivation of cyclin-dependent kinase (CDK) (9). G1 to S phase transition is one of the most important steps in the cell cycle which brings cells to DNA replication followed by G2 phase and subsequent mitosis.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have demonstrated that antidepressants decrease the risk of breast cancer development (1)(2)(3)(4). On the other hand, several studies have reported that antidepressants increase the risk of nonHodgkin lymphoma and prostate cancer (5,6), and it is still controversial what effect tricyclic antidepressants have on lung, breast and colon cancer cells (7)(8)(9). Both in vitro and in vivo studies indicate antidepressants are cytotoxic to most malignant cells, particularly colon and breast cancer (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Effects of desipramine on the cell cycle and apoptosis in Ca3/7 mouse skin squamous carcinoma cells

Hanausek,¹

2010

Int J Mol Med

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Abstract. Desipramine (DMI) has been reported to induce glucocorticoid receptor-mediated signal transduction in recent studies. It has been suggested that a non-glucocorticoid receptor signaling pathway might play an important role in skin squamous carcinoma Ca3/7 cells. The aim of this study was to investigate the growth inhibitory effects of DMI on Ca3/7 cells by evaluating the mRNA expression of genes related to apoptosis and cell cycle progression. Hoechst nuclear staining and DNA fragmentation assays were used to detect apoptosis, and the cell cycle was analyzed by flow cytometry. Apoptotic bodies in the nuclei of cells and DNA fragmentation were observed when the Ca3/7 cells were treated with 20 μM DMI for 24 h. Quantitative RT-PCR (reverse transcriptional-polymerase chain reaction) showed that DMI caused a decrease in Bcl-2 and survivin but not Bcl-xL gene expression and an increase in the expression of Bax, Apaf-1, caspase-3 and caspase-7 in a dose-and timedependent manner. DMI also caused translocation of the apoptosis-inducing factor from the cytoplasm to the nucleus as well as cell cycle arrest in the Ca3/7 cells. Quantitative RT-PCR revealed that DMI decreased the expression of the PCNA gene and caused an increase in the expression of the p21 and p27 genes in the Ca3/7 cells. Our results showed that DMI inhibited the growth of Ca3/7 cells by inducing both apoptosis and cell cycle arrest.

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Use of antidepressants and risk of colorectal cancer: a nested case-control study

Cited by 121 publications

References 40 publications

Serotonin Regulates Macrophage-Mediated Angiogenesis in a Mouse Model of Colon Cancer Allografts

Serotonin Regulates Macrophage-Mediated Angiogenesis in a Mouse Model of Colon Cancer Allografts

S‐adenosyl L‐methionine inhibits azoxymethane‐induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco‐2 cell growth in 3D culture

Effects of desipramine on the cell cycle and apoptosis in Ca3/7 mouse skin squamous carcinoma cells

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