Use of Anti-Inflammatory Drugs interventions for the treatment of Muscle Soreness: a Systematic Review and Meta-analysis.

Abstract

Objective: To investigate the effects of pharmacological interventions in the treatment of Delayed Onset Muscle Soreness (DOMS). Design: Systematic review and meta-analysis of randomised controlled clinical trials (RCTs). Data sources: The PubMed / MEDLINE, EMBASE, SPORTDiscus, Scielo and CENTRAL (Cochrane Central Register of Controlled Trials) databases were searched from the oldest records to August 3, 2020. Eligibility criteria: 1) Tue used a RCTs design; 2) Evaluate the effects of Steroidal or Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) for treatment DOMS; and 3) Therapeutically used drugs, after exercise. Results: In total, 26 studies (patients = 934) were eligible for qualitative analysis on the treatment of DOMS. The results of the meta-analysis showed no superiority between the use or not of NSAIDs, in the improvement of late muscle pain, since statistically significant differences were not verified (21 studies, n= 955; SMD= 0.02; 95% CI -0.58, 0.63; p=0.94; I2=93%). The quality of the synthesized evidence was very low according to the criteria of Evaluation, Development and Evaluation of the Classification of Recommendations, associated with the significant heterogeneity among the included studies. Conclusion: The results demonstrate that the use of NSAIDs is not a superior treatment to the control / placebo on DOMS improvement. The variation between dose-response and exercise protocol used in the studies may have influenced the results. In addition, the high risk of identified bias characterizes limitation to be considered in profound interpretations.

La hidroterapia y sus efectos sobre el dolor muscular tardío en deportistas: una revisión sistemática (Hydroterapy and its effects on delayed onset muscle soreness in athletes: a systematic review)

“…Para evitar o disminuir los efectos negativos del DOMS se han implementado diversas estrategias, entre las que destacan el uso de fármacos antiinflamatorios (Nahon, et al, 2020), terapia vibratoria (Lu, et al, 2019), prendas de compresión (Marqués-Jiménez, et al, 2016), masaje (Davis, et al, 2020), uso del Foam Roller (Romero- Moraleda, et al, 2020) entre otras, sin embargo, aún está a discusión cuál de los métodos antes mencionados es la mejor elección como herramienta de recuperación y tratamiento del DOMS ( López, et al, 2021).…”