Use of Anterior Segment Optical Coherence Tomography to Study Corneal Changes After Collagen Cross-linking

Doors, Muriël; Tahzib, Nayyirih G.; Eggink, Fred A.G.J.; Berendschot, Tos T. J. M.; Webers, Carroll A.B.; Nuijts, Rudy M.M.A.

doi:10.1016/j.ajo.2009.06.031

Cited by 168 publications

(101 citation statements)

References 19 publications

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“…The corneal demarcation line is described as a hyperreflective line seen in anterior segment optical coherence tomography (AS OCT) 1 month after C-CXL at a depth of 300 µm , and measurement of the corneal demarcation line depth in AS OCT 1 month after CXL has been proposed as an efficient clinical method for evaluation of CXL effectiveness 18 .…”

Section: Introductionmentioning

confidence: 99%

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Bouheraoua

Jouve

Borderie

et al. 2015

JoVE

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Keratoconus is a bilateral and progressive corneal ectasia. In order to slow down its progression, corneal collagen cross-linking (CXL) has recently been introduced as an efficient treatment option. In biological and chemical sciences, crosslinking refers to new chemical bonds formed between reactive molecules. Hence, the aim of corneal collagen CXL is to synthetically increase the formation of crosslinks between collagen fibrils in the corneal stroma. Despite the fact that the efficiency of the conventional CXL (C-CXL) protocol has already been shown in several clinical studies, it might benefit from improvements in duration of the procedure and removal of corneal epithelium. Hence, in order to provide a coherent evaluation of two new and optimized CXL protocols, we studied keratoconus patients who had undergone one of the three CXL treatments: iontophoresis (I-CXL), accelerated CXL (A-CXL), and conventional CXL (C-CXL). A-CXL is a 6 time faster CXL procedure using a ten time higher UVA irradiance but still including an epithelium removal. Iontophoresis is a transepithelial non-invasive technique in which a small electric current is applied to improve riboflavin penetration throughout the cornea. Using anterior segment optical coherence tomography (AS OCT) and in vivo confocal microscopy (IVCM), we conclude that regarding the depth of treatment penetration, conventional CXL protocol remains the standard for treating progressive keratoconus. Accelerated CXL seems to be a quick, effective and safe alternative to treat thin corneas. The use of iontophoresis is still being investigated and should be considered with greater caution. Video LinkThe video component of this article can be found at

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Section: Introductionmentioning

confidence: 99%

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Bouheraoua

Jouve

Borderie

et al. 2015

JoVE

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“…Additionally, we observed a reduction in corneal thickness which was greater at the three month follow-up and remained stable after one year. Others have previously reported comparable thinning with Scheimpflug imaging [7] and with AS-OCT [8]. It remains to be established whether these findings reflect true corneal thinning or are artifacts caused by changes in the optical properties of the corneal stroma after CXL.…”

Section: Discussionmentioning

confidence: 90%

“…In this regard, Doors, et al found a positive correlation between the demarcation line depth and corneal thickness reduction [8]. To sum up, AS-OCT can consistently identify qualitative changes in corneae treated with CXL.…”

Section: Discussionmentioning

confidence: 95%

“…A recent study with AS -OCT [8] identified the stromal demarcation line that allegedly represents the treatment penetration depth [4,9] and further explored its implications. In our series, we observed this finding in all patients at three and six months as a hyperreflective line at an average depth of 365 ± 56 gm that progressively reduced its intensity until becoming unidentifiable in 50% of the cases after 12 months.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Corneal Crosslinking for Keratoconus Assessed with Anterior Segment Optical Coherence Tomography

Bonthoux¹,

Galletti²,

Tytiun³

et al. 2012

Cureus

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“…По данным различных авторов, демаркационная линия, как правило, появляется, начиная со 2-й недели после CXL и сохраняется в течение трех месяцев на различной глубине стромы в зависимости от применяемого прото-кола кросслинкинга [8,9]. В большинстве исследований эффективность процедуры кросслинкинга в основном оценивают по уплощению центральной зоны роговицы [10]. Отдельные авторы отмечают прогрессивный харак-тер эктатического процесса в периферической зоне рого-вицы [11].…”

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Topographic Localization of the Demarcation Line after UV Corneal Crosslinking in Progressive Keratoconus

Бикбов¹,

Суркова²,

Khalimov³

et al. 2018

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Use of Anterior Segment Optical Coherence Tomography to Study Corneal Changes After Collagen Cross-linking

Cited by 168 publications

References 19 publications

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Effects of Corneal Crosslinking for Keratoconus Assessed with Anterior Segment Optical Coherence Tomography

Topographic Localization of the Demarcation Line after UV Corneal Crosslinking in Progressive Keratoconus

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