Use of Active Surveillance to Validate <i>International Classification of Diseases</i> Code Estimates of Rotavirus Hospitalizations in Children

Hsu, Vincent; Staat, Mary Allen; Roberts, Nancy; Thieman, Carla; Bernstein, David I.; Bresee, Joseph S.; Glass, Roger I.; Parashar, Umesh D.

doi:10.1542/peds.2004-0860

Cited by 108 publications

(83 citation statements)

References 17 publications

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“…Rotavirus is responsible for a substantial, yet underestimated, number of hospitalisations of children with acute gastroenteritis [17]. The incidence of rotavirus diarrhoea requiring hospital admission in children presenting at the emergency department was 40%, which is similar to that reported in other European countries [11,18,20,21], but lower than the 70% rate found in Canada [24].…”

Section: Discussionsupporting

confidence: 56%

Rotavirus and not age determines gastroenteritis severity in children: a hospital-based study

et al. 2006

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Section: Discussionsupporting

confidence: 56%

Rotavirus and not age determines gastroenteritis severity in children: a hospital-based study

et al. 2006

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“…We note that our estimate of 52% for the RV-fraction is similar to a recent US estimate (49%) obtained using direct linkage of hospital admissions and pathology data. 13 In addition to providing estimates of RV disease burden in young children in Australia, the study provided an opportunity to examine methodology for obtaining estimates of the RV fraction in light of data sources and admission coding practices. While an RV-specifi c ICD code (A08.0) has been available for some time, the number of AGE admissions for which a specifi c aetiology is not indicated in the patient record remains a large impediment to direct estimation of the RV fraction from routinely available data.…”

Section: General Practitioner (Gp) Visitsmentioning

confidence: 99%

The burden of rotavirus‐related illness among young children on the Australian health care system

Galati

Harsley

Richmond

et al. 2006

Australian and New Zealand Journal of Public Health

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R otavirus (RV) is a major cause of acute gastroenteritis (AGE) in children under the age of fi ve and is a signifi cant cause of early childhood mortality in developing countries and morbidity in developed countries.1 Estimates for Australia from the mid 1990s put the direct national healthcare burden of RV at 10,000 hospital admissions 2 and 50,000 primary care visits 3 annually. These estimates were compiled to provide primary data for a cost-effectiveness analysis of RV vaccination in Australia. 3The previous cost-effectiveness analysis was framed around the vaccine Rotashield, which was licensed in the United States in 1998 but was voluntarily withdrawn from the market by its manufacturer a short time later after surveillance revealed an increased incidence of intussusception in infants who had been immunised. 4 Since then, several new RV vaccines have been under development and two were approved for use in Australia in 2006.5 In this context, this paper presents updated epidemiological data on numbers and costs of hospitalisations of young children in Australia for AGE and on the fraction of these hospitalisations that are attributable to RV (the 'RV fraction'). Estimates of numbers and costs of emergency department (ED) visits and numbers of general practitioner (GP) visits in Australia for RV-AGE are also included. A new method for estimating the RV fraction on the basis of the seasonal pattern of incidence is used.

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“…Thus, all children born in the region, regardless of their vaccination status, are included in LOGIVAC. 15 Both primary and secondary diagnoses were considered, and two hospitalizations for the same infant occurring in less than 14 days were considered as one event. Hospitalizations rates were calculated by dividing the number of hospitalizations that occurred among children aged less than five years by the total number of children of the same age group in the birth cohort over a specified period.…”

Section: Data Sourcesmentioning

confidence: 99%

Trends in severe gastroenteritis among young children according to socio-economic characteristics before and after implementation of a rotavirus vaccination program in Quebec

Gosselin

Petit

Gagneur

et al. 2016

Can J Public Health

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OBJECTIVES: Following implementation of a publicly funded rotavirus immunization program in Quebec (Canada) in 2011, its impact on gastroenteritis hospitalization rates, a proxy for severe gastroenteritis, was assessed.METHODS: Using a tertiary hospital database and a regional vaccination registry, temporal trends in rates of hospitalization for acute gastroenteritis (AGE) and rotavirus gastroenteritis before the age of five years and rotavirus vaccine coverage were examined from June 2004 through May 2014 in a large retrospective birth cohort in the Eastern Townships region. The mean annual AGE hospitalization rate in post-program years (2011/2012-2013/2014) was compared with that in pre-program years (2004/2005-2010/2011) overall and according to the characteristics of the children, families and residential neighbourhoods at birth. RESULTS:The AGE hospitalization rate significantly decreased from 81/10,000 in the pre-program period to 46/10,000 in the post-program period (relative reduction = 43%). Following implementation of the program, vaccine coverage rapidly increased and reached 81%. All socio-economic categories showed a reduced hospitalization rate in the post-program period, but the lowest relative reductions were observed in children living in neighbourhoods with higher rates of unemployment, low-income families and single mothers. However, these disadvantaged subgroups did not have lower vaccine coverage.CONCLUSIONS: Three years following its introduction in a universal vaccination program, rotavirus vaccine significantly reduced severe gastroenteritis in young children. Despite similar vaccine coverage among all children, disadvantaged socio-economic groups appeared to have a less pronounced AGE reduction, suggesting that factors other than vaccination could partially influence the reduction of gastroenteritis morbidity in young children.KEY WORDS: Rotavirus infections; rotavirus vaccines; immunization programs; gastroenteritis; child; socio-economic La traduction du résumé se trouve à la fin de l'article.

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Use of Active Surveillance to Validate International Classification of Diseases Code Estimates of Rotavirus Hospitalizations in Children

Abstract: Measurement of rotavirus-coded hospital discharges alone seems to greatly underestimate the true burden of rotavirus-associated hospitalizations. The numbers of national rotavirus hospitalization discharges may be substantially greater than previously estimated.

Cited by 108 publications

References 17 publications

Rotavirus and not age determines gastroenteritis severity in children: a hospital-based study

Rotavirus and not age determines gastroenteritis severity in children: a hospital-based study

The burden of rotavirus‐related illness among young children on the Australian health care system

Trends in severe gastroenteritis among young children according to socio-economic characteristics before and after implementation of a rotavirus vaccination program in Quebec

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