Rotavirus and not age determines gastroenteritis severity in children: a hospital-based study

Albano, Fabio; Bruzzese, Eugenia; Bella, Antonino; Cascio, Antonio; Titone, Lucina; Arista, Serenella; Izzi, Giancarlo; Virdis, R; Pecco, P; Principi, Nicola; Fontana, Massimo; Guarino, Alfredo

doi:10.1007/s00431-006-0237-6

Cited by 56 publications

(49 citation statements)

References 33 publications

(25 reference statements)

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“…The most vulnerable of all the age groups were the children who are below the age of five years and it has been observed that the children [5 years of age have considerably increased RV infection rate in comparison with the adults (P \ 0.0001). Studies have reported that the most RV infections in children occurs before the age of 2 years [1,10,32,36] and in this study also the children \2 years of age demonstrated highest rate (50 %) of RV infections among all the patients belonging to different stages of life. EV infection was evenly distributed between the children (\5 years old) and adult ([5 years old) patient groups.…”

Section: Discussionsupporting

confidence: 66%

Prevalence of rotavirus, norovirus and enterovirus in diarrheal diseases in Himachal Pradesh, India

et al. 2016

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Diarrheal diseases are responsible for a significant proportion of mortality and morbidity all around the globe. The contribution of viruses to gastroenteritis incidences in humans is well established. In the present study, we have studied the prevalence of rotavirus, norovirus and enterovirus in Himachal Pradesh, a north Indian state. A total of 287 (111 children and 176 adults) stool samples of gastroenteritis patients were screened for the viruses using RT-PCR method. 34.5 % samples were positive for the viral pathogens of gastroenteritis. Rotavirus was the predominant virus detected in the study with 49.5 and 14.8 % positivity in children and adults, respectively. Enterovirus was present in 5.6 % cases whereas norovirus had least prevalence (1.4 %). Co infection (rotavirus and enterovirus) was witnessed at the prevalence rate of 0.6 %. Among different age groups, the prevalence of studied viruses was highest in the children belonging to the age groups of \5 years. Rotavirus infections were found to be significantly associated with vomiting and trend of higher rates of fever and dehydration was seen in children along with diarrhea. Seasonal distribution shows circulation of diarrheagenic viruses throughout the year. This is the first report of prevalence of various diarrheagenic viruses circulating in this region. The outcome of the study from this cohort provides a baseline data which can be used to design the preventive strategies in the otherwise unexplored state of Himachal Pradesh.

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Section: Discussionsupporting

confidence: 66%

Prevalence of rotavirus, norovirus and enterovirus in diarrheal diseases in Himachal Pradesh, India

et al. 2016

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“…This is in agreement with a study carried out in Sudan (2010) which shows that children of illiterate parents are more infected with rotavirus [4]. This may reflect the relation of educational level of mother with hygiene as a risk factor for rotavirus infection [17].…”

Section: Pediatric Infectious Diseases: Open Access Issn 2573-0282supporting

confidence: 92%

“…Some studies found a relation between rotavirus diarrhea and male gender as a risk fact [16,17]. It was found that positive rotavirus result reported in children belong to young mothers with low education.…”

Section: Pediatric Infectious Diseases: Open Access Issn 2573-0282mentioning

confidence: 99%

Rotavirus Diarrhea in Children Under Five in Basrah: Hospital Based Study

Habash¹,

Habeeb²

2018

Pediatric Infect Dis

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“…Data about RV morbidity in Europe are available mainly for southern [2,9,26], northern [16,31], and western parts [1,3,6,11,28]. Only a few studies were performed in eastern Europe [22].…”

Section: Introductionmentioning

confidence: 99%

A 4-year study on clinical characteristics of children hospitalized with rotavirus gastroenteritis

et al. 2009

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Rotavirus (RV) is a frequent cause of severe gastroenteritis (GE) in children. With the licensure of new RV vaccines, data on the burden of disease are important regarding immunization strategies. We reviewed the medical records of children hospitalized with RV infection in our institution between July 2002 and March 2006. Relevant data were extracted in a standardized fashion from records of hospitalized children with a positive RV antigen test in a stool sample. Severity of disease was graded by the 20-point Vesikari score. Population data were obtained from the Federal Office of Statistics. Six hundred eighty-six RVGE were identified and records of 608 hospitalizations (in 607 children) were available. In 539 (89%) cases, RVGE was the primary reason for hospitalization and 69 (11%) were nosocomial infections; yearly peaks occurred between February and May. Cumulative incidence of RVGE was 26.7/1,000 children <3 years of age. Median age of 539 children (55.6% male) with primary RVGE was 1.4 years and median stay in the hospital for both community acquired and nosocomial RVGE was 4 days (interquartile range 3-5). Thirtypercent and 94% of RV hospitalizations were in children <1 and <3 years of age, respectively. Mean Vesikari score was 15 (range 6-20; 96% >11). Intravenous fluids were administered in 378 (70%) patients, 130 (24%) patients were rehydrated via nasogastral tube, and 31 (5.7%) received rehydration by mouth. RVGE causes a substantial burden in children with an estimated risk for hospitalization due to RVGE of one in 37 children <3 years of age.

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Rotavirus and not age determines gastroenteritis severity in children: a hospital-based study

Abstract: These data provide the evidence that aetiology and not age determines diarrhoeal severity. The demonstration that diarrhoea was more severe in rotavirus-positive children supports the need for a rotavirus vaccine and for studies that address the duration of vaccine protection.

Cited by 56 publications

References 33 publications

Prevalence of rotavirus, norovirus and enterovirus in diarrheal diseases in Himachal Pradesh, India

Prevalence of rotavirus, norovirus and enterovirus in diarrheal diseases in Himachal Pradesh, India

Rotavirus Diarrhea in Children Under Five in Basrah: Hospital Based Study

A 4-year study on clinical characteristics of children hospitalized with rotavirus gastroenteritis

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