Use of a Software Development and Support Environment as Government- Furnished Equipment (GFE)

Werling, Richard; Houghton, Raymond C; Chande, A M

doi:10.21236/ada159374

Cited by 1 publication

(1 citation statement)

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“…A positive correlation was seen between BMI and fasting total secondary BAs in subjects with HOMA-IR≤ 2.8. A study in obese subjects showed that GLCA (a conjugated secondary BA) levels decreased after bariatric surgery (12). The relative composition of the gut flora during early life can predict the subsequent development of obesity (13).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Bile acid metabolism is altered in those with insulin resistance after gestational diabetes mellitus

Maghsoodi

Shaw

Cross

et al. 2019

Clinical Biochemistry

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Bile acid metabolism is altered in those with insulin resistance after gestational diabetes mellitus. Clb (2018), https://doi. AbstractBackground: Bile acids (BAs) are known mediators of glucose metabolism that are altered in type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM).We hypothesised that post-prandial BA fractions are changed in women with Insulin resistance (IR) after recovery from GDM using homeostatic model assessment (HOMA-IR). Methods: 45 women median age 44(31-47) with previous GDM, including 20 with HOMA-IR >2.8 and 25 age-matched controls with HOMA-IR ≤ 2.8 were studied. After an overnight fast, all underwent an oral glucose tolerance test. Blood samples were collected at baseline and every 30min for 120min and analysed for glucose on automated platform and for total BAs, their conjugates and fractions using liquidchromatography tandem mass-spectrometry. Baseline samples were analysed for insulin on automated platform. Delta (Δ) change (difference between baseline and maximal post-prandial response) were calculated. Data is presented as median (IQR). Results: Fasting primary and unconjugated BAs were higher in women with HOMA-IR >2.8 vs. those with HOMA-IR ≤ 2.8 [0.24 (0.16-0.33) vs 0.06(0.04-0.22) µmol/L and 0.91(0.56-1.84) µmol/L vs. 0.69(0.32-0.89) µmol/L respectively. ∆ taurine-conjugated BAs was higher in women with HOMA-IR ≤ 2.8 than those with HOMA-IR>2.8 [0.33(0.20-0.54) vs 0.23(0.13-0.34) µmol/L]. Fasting glucose and non-12αhydroxylated BAs were negatively correlated in women with HOMA-IR >2.8 (all p<0.05). Conclusions:Following GDM, individuals with HOMA-IR >2.8 have altered conjugated and non-12α-hydroxylated fractions of BAs. It remains to be elucidated if the altered BA metabolism is a contributing factor to the pathogenesis or a consequence of GDM.

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Section: Accepted Manuscriptmentioning

confidence: 99%