Bile acid metabolism is altered in those with insulin resistance after gestational diabetes mellitus

Maghsoodi, Negar; Shaw, Nicholas; Cross, Gemma F.; Alaghband‐Zadeh, Jamshid; Wierzbicki, Anthony S.; Pinkney, Jonathan; Millward, Ann; Vincent, Royce P.

doi:10.1016/j.clinbiochem.2018.11.016

Cited by 16 publications

(18 citation statements)

References 17 publications

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“…We found that glycine-conjugated BA was positively associated with fasting insulin and HOMA-IR. This finding is consistent with a recent study that reported altered BA metabolism among GDM women, in which a positive correlation between fasting, insulin, and HOMA-IR and glycine-and taurine-conjugated BAs was observed [33]. THDCA value was higher in mothers with GDM [12], though such a difference was not seen in our study.…”

Section: Discussionsupporting

confidence: 93%

Effect of Lactobacillus rhamnosus Probiotic in Early Pregnancy on Plasma Conjugated Bile Acids in a Randomised Controlled Trial

Chen

Wickens

et al. 2021

Nutrients

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We have previously shown that probiotic supplementation with Lactobacillus rhamnosus HN001 (HN001) led to a reduced incidence of gestational diabetes mellitus (GDM). Here we investigate whether HN001 supplementation resulted in alterations in fasting lipids, insulin resistance, or bile acids (BAs) during pregnancy. Fasting plasma samples collected at 24–30 weeks’ gestation, from 348 women randomised at 14–16 weeks’ gestation to consume daily probiotic HN001 (n = 172) or a placebo (n = 176) were analysed for lipids, insulin, glucose and BAs. Women supplemented with HN001 had lower fasting glucose compared with placebo (p = 0.040), and lower GDM. Significant differences were found in fasting insulin, HOMA-IR, low density lipoprotein-cholesterol (LDL-c), high density lipoprotein (HDL)-c, triglycerides, total cholesterol, and BAs by GDM status. Lower fasting conjugated BAs were seen in women receiving HN001. A significant decrease of glycocholic acid (GCA) was found in older (age ≥ 35) women who received HN001 (p = 0.005), while GDM women showed significant reduced taurodeoxycholic acid (TDCA) (p = 0.018). Fasting conjugated BA was positively correlated with fasting glucose (r = 0.136, p = 0.020) and fasting insulin (r = 0.113, p = 0.036). Probiotic HN001 supplementation decreases conjugated BAs and might play a role in the improvement of glucose metabolism in women with pregnancy.

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Section: Discussionsupporting

confidence: 93%

Effect of Lactobacillus rhamnosus Probiotic in Early Pregnancy on Plasma Conjugated Bile Acids in a Randomised Controlled Trial

Chen

Wickens

et al. 2021

Nutrients

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“…So while the importance of ASBT for bile acid absorption and the resulting lipid absorption/homeostasis is fairly evident, interestingly, very little is known about how ASBT may be affected in obesity where dyslipidemia is common and the consequential morbidities are numerous. Emerging evidence suggests altered bile acid assimilation as a potential factor in obesity-associated conditions such as type 2 diabetes mellitus and nonalcoholic fatty liver disease [59,60,61,62]. Further, increased dietary lipid absorption resulting in altered lipid homeostasis of obesity has been attributed to increased bile acid levels in enterohepatic circulation [5,6,7].…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Dyslipidemia in Obesity—Unique Regulation of Ileal Villus Cell Brush Border Membrane Sodium–Bile Acid Cotransport

Sundaram

Palaniappan

Nepal

et al. 2019

Cells

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In obesity, increased absorption of dietary fat contributes to altered lipid homeostasis. In turn, dyslipidemia of obesity leads to many of the complications of obesity. Bile acids are necessary for the absorption of dietary fat. In the mammalian intestine, apical sodium-dependent bile acid cotransporter (ASBT; SLC10A2) is exclusively responsible for the reabsorption of bile acids in the terminal ileum. In rat and mice models of obesity and importantly in obese humans, ASBT was increased in ileal villus cells. The mechanism of stimulation of ASBT was secondary to an increase in ASBT expression in villus cell brush border membrane. The stimulation of ASBT was not secondary to the altered Na-extruding capacity of villus cells during obesity. Further, increased Farnesoid X receptor (FXR) expression in villus cells during obesity likely mediated the increase in ASBT. Moreover, enhanced FXR expression increased the expression of bile-acid-associated proteins (IBABP and OSTα) that are responsible for handling bile acids absorbed via ASBT in villus cells during obesity. Thus, this study demonstrated that in an epidemic condition, obesity, the dyslipidemia that leads to many of the complications of the condition, may, at least in part, be due to deregulation of intestinal bile acid absorption.

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“…Similarly, we found that the concentration of cholic acid in MDE-treated rats was significantly decreased, indicating that the primary bile acid biosynthesis pathway was inhibited, which is also beneficial for the inhibition of cholesterol absorption (Maghsoodi et al. 2019).…”

Section: Discussionmentioning

confidence: 72%

UHPLC/QTOF-MS-based metabolomics reveal the effect of Melastoma dodecandrum extract in type 2 diabetic rats

Weng

Zhou

Liang

et al. 2019

Pharmaceutical Biology

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Context: Melastoma dodecandrum Lour. (Melastomataceae) is a traditional Chinese medicine. This is the first study to report a protective effect of the ethanol extract from M. dodecandrum (MDE) in type 2 diabetic (T2DM) rats. Objective: To investigate the therapeutic mechanism of MDE in T2DM rats. Materials and methods: Sprague-Dawley rats were fed a high-fat diet for 6 consecutive weeks, followed by intraperitoneal injection of streptozotocin (STZ) (30 mg/kg) to induce diabetes. T2DM rats were divided into untreated diabetic, metformin-treated and MDE-treated groups. Additionally, normal rats without treatment served as the control group (n ¼ 6). Metformin (250 mg/kg) and MDE (600 mg/kg) were intragastrically administered to T2DM rats for 5 consecutive weeks. Serum samples were evaluated via ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC/QTOF-MS), followed by principal components analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA). Results: The 17 identified potential biomarkers were mainly involved in lipid, amino acid, arachidonic acid, taurine and nicotinic acid metabolism. MDE also significantly reduced the level of fasting blood glucose (FBG), oral glucose tolerance, insulin, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), malondialdehyde (MDA), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and urea nitrogen (BUN) in T2DM rats. The high-density lipoprotein (HDL), serum creatinine (Scr), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) levels were elevated in MDE-treated group. Discussion and conclusion: MDE possesses substantial antidiabetic activity, especially in lipid disorder regulation. This suggests that the use of MDE can be generalized to broader pharmacological studies, such as obesity and hyperlipidaemia.

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Bile acid metabolism is altered in those with insulin resistance after gestational diabetes mellitus

Cited by 16 publications

References 17 publications

Effect of Lactobacillus rhamnosus Probiotic in Early Pregnancy on Plasma Conjugated Bile Acids in a Randomised Controlled Trial

Effect of Lactobacillus rhamnosus Probiotic in Early Pregnancy on Plasma Conjugated Bile Acids in a Randomised Controlled Trial

Mechanism of Dyslipidemia in Obesity—Unique Regulation of Ileal Villus Cell Brush Border Membrane Sodium–Bile Acid Cotransport

UHPLC/QTOF-MS-based metabolomics reveal the effect of Melastoma dodecandrum extract in type 2 diabetic rats

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