Use of a social jetlag-mimicking mouse model to determine the effects of a two-day delayed light- and/or feeding-shift on central and peripheral clock rhythms plus cognitive functioning

Haraguchi, Atsushi; Nishimura, Yutaro; Fukuzawa, Miyabi; Kikuchi, Yoshihiro; Tahara, Yu; Shibata, Shigenobu

doi:10.1080/07420528.2020.1858850

Cited by 8 publications

(8 citation statements)

References 66 publications

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“…While MWT acquisition was unaffected, retention was impaired 17 days later, despite having had a normal 24 h day-length since the end of training. This finding has been replicated ( Devan et al, 2001 ; Zelinski et al, 2014 ), and similar designs from other labs ( Gibson et al, 2010 ; Loh et al, 2010 ; Iggena, 2017 ; Horsey et al, 2020 ; Lewis et al, 2020 ; Haraguchi et al, 2021 ) also produce memory impairments.…”

Section: Introductionsupporting

confidence: 70%

Impaired Morris water task retention following T21 light dark cycle exposure is not due to reduced hippocampal c-FOS expression

Deibel¹,

Higdon²,

Cassell³

et al. 2022

Front. Behav. Neurosci.

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Circadian rhythms influence virtually all aspects of physiology and behavior. This is problematic when circadian rhythms no longer reliably predict time. Circadian rhythm disruption can impair memory, yet we don’t know how this fully works at the systems and molecular level. When trying to determine the root of a memory impairment, assessing neuronal activation with c-FOS is useful. This has yet to be assessed in the hippocampi of circadian rhythm disrupted rats in a hippocampal gold standard task. Rats were trained on the Morris water task (MWT), then received 6 days of a 21-h day (T21), 13 days of a normal light dark cycle, probe trial, and tissue extraction an hour later. Despite having impaired memory in the probe trial, compared to controls there were no differences in c-FOS expression in hippocampal sub regions: CA1; CA3; Dentate gyrus. These data confirm others in hamsters demonstrating that arrhythmicity which produces an impairment in spontaneous alternation does not affect c-FOS in the dentate gyrus. The current study indicates that the memory impairment induced by a lighting manipulation is likely not due to attenuated neuronal activation. Determining how the master clock in the brain communicates with the hippocampus is needed to untangle the relationship between circadian rhythms and memory.

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Section: Introductionsupporting

confidence: 70%

Impaired Morris water task retention following T21 light dark cycle exposure is not due to reduced hippocampal c-FOS expression

Deibel¹,

Higdon²,

Cassell³

et al. 2022

Front. Behav. Neurosci.

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“…Experiment 1: Effect of Wheel-Running Exercise on the Behavioral Rhythm in the Social Jet Lag Condition During Normal Diet Feeding Condition First, we examined the activity rhythms of mice fed with ND in the SJL condition. We measured the amount of behavior under the rearing conditions that included a temporary delay of the LD condition for 2 days (Saturday and Sunday) as shown in a previous study (Haraguchi et al, 2021). After being kept under normal LD conditions for one week, the mice experienced a delay in light conditions for 2 days, and their recovery from the delay was observed over the next 5 days.…”

Section: Resultsmentioning

confidence: 99%

“…All mice in this study were kept in a sensor-equipped chamber, and the LD conditions were controlled for each experiment. First, in Experiments 1∼4, we delayed the LD condition by 6 h only on two consecutive days corresponding to Saturday and Sunday, defined as the SJL condition, and returned to the normal LD condition on Monday ( Haraguchi et al, 2021 ). There are several previous studies that use LD cycle changes mimicking SJL.…”

Section: Methodsmentioning

confidence: 99%

“…This study examined whether the time lag of the circadian clock system would be improved by the presence or absence of exercise, which is relevant to the central and peripheral clocks and can be incorporated into daily life. As a model that reflects the phenomenon of SJL, our previous study reported a model in which the LD conditions recede only on 2 days that fall on holidays ( Haraguchi et al, 2021 ). A previous paper has demonstrated that wheel-running exercise delayed both general rhythm and peripheral rhythm such as in the liver and spleen without affecting SCN rhythm ( Pendergast et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Wheel-Running Facilitates Phase Advances in Locomotor and Peripheral Circadian Rhythm in Social Jet Lag Model Mice

et al. 2022

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The circadian clock maintains our health by controlling physiological functions. Social jet lag is one factor that can disrupt the body clock. This is caused by the difference in sleeping hours between weekdays when we live according to social time and holidays when we live according to our body clock. The body clock can be altered by exercise, nutrition, and stress, and several studies have reported that these factors can be used to improve a disturbed body clock. Here we focused on exercise and examined whether continuous wheel-running could improve the disordered body clock in a mouse model that mimics social jet lag. The results showed that the wheel-running exercise group showed faster synchronization of the onset of activities on weekdays which had been delayed by social jet lag and the results were even more pronounced in the high-fat diet feeding condition. Also, when the expression rhythms of the clock genes were examined, they experienced a sudden time shift in the advance light condition or social jet lag condition, it was found that the wheel-running group had a higher ability to adapt to the advance direction. Thus, it is possible that the effective inclusion of exercise in human, especially those who eat high-fat foods, life can improve the disordered body clock in terms of social jet lag.

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“…Notably, in mice, LAN not only disrupts circadian rhythms, but also alters metabolism, immune function, stress, anxiety-like behavior, and mood-related behaviors ( Fonken et al, 2010 ; Bedrosian et al, 2013 ; Fonken et al, 2013 ; Fonken and Nelson, 2014 ; Russart and Nelson, 2018 ; Walker et al, 2020a , Walker et al, 2020b ; Bumgarner and Nelson, 2021 , Walker et al, 2021 ). However, more translational models of circadian rhythm disruption such as LAN, or even social jet lag and shift work ( Wittmann et al, 2006 ; Barclay et al, 2012 ; Opperhuizen et al, 2015 ; Haraguchi et al, 2021 ; Oneda et al, 2022 ), have been heavily underutilized in the study of circadian rhythm disruption and drug abuse, especially in the context of VTA and NAc circadian function. Future studies would benefit from utilizing these models to understand how unhealthy light practices (e.g., LAN, social jet lag, night shift work, etc.)…”

Section: Implications For Reward and Substance Abusementioning

confidence: 99%

The Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders

2022

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Circadian rhythms convergently evolved to allow for optimal synchronization of individuals’ physiological and behavioral processes with the Earth’s 24-h periodic cycling of environmental light and temperature. Whereas the suprachiasmatic nucleus (SCN) is considered the primary pacemaker of the mammalian circadian system, many extra-SCN oscillatory brain regions have been identified to not only exhibit sustainable rhythms in circadian molecular clock function, but also rhythms in overall region activity/function and mediated behaviors. In this review, we present the most recent evidence for the ventral tegmental area (VTA) and nucleus accumbens (NAc) to serve as extra-SCN oscillators and highlight studies that illustrate the functional significance of the VTA’s and NAc’s inherent circadian properties as they relate to reward-processing, drug abuse, and vulnerability to develop substance use disorders (SUDs).

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Use of a social jetlag-mimicking mouse model to determine the effects of a two-day delayed light- and/or feeding-shift on central and peripheral clock rhythms plus cognitive functioning

Cited by 8 publications

References 66 publications

Impaired Morris water task retention following T21 light dark cycle exposure is not due to reduced hippocampal c-FOS expression

Impaired Morris water task retention following T21 light dark cycle exposure is not due to reduced hippocampal c-FOS expression

Wheel-Running Facilitates Phase Advances in Locomotor and Peripheral Circadian Rhythm in Social Jet Lag Model Mice

The Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders

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