Use of a new cardiac pacing mode designed to eliminate unnecessary ventricular pacing

Abstract

AAIsafeR2 mode seems to be safe and reliable in patients with infrequent slowing or pauses in ventricular activity, while maintaining ventricular pacing below 1%.

Near Elimination of Ventricular Pacing in SafeR Mode Compared to DDD Modes: A Randomized Study of 422 Patients

“…Therefore, various pacing modes were developed in recent years to favor spontaneous AV conduction. The SafeR™ pacing mode (SORIN Group CRM SAS, Clamart, France), designed to combine the advantages of AAI with the safety of DDD mode, has been described in detail elsewhere 13,14 . The first recently published clinical application of SafeR in selected pacemaker recipients showed that it was associated with a marked decrease in the percentage of ventricular paced events.…”

AAIsafeR Limits Ventricular Pacing in Unselected Patients

“…In that case pacing was permanently reprogrammed to DDD. The upgraded AAIsafeR version 2 has been incorporated in the Symphony™ DR 2550 pacemaker (ELA Medical, Montrouge, France) since March 2005, with a view to remedy this deficiency by systematically switching to AAI every morning, and by improving the management of first‐degree AV block 17 . At night, when vagal tone slows AV conduction, AAIsafeR intends to prevent ventricular pacing, with minimal hemodynamic consequences, as long as the heart rate is preserved.…”

Very Low Ventricular Pacing Rates Can Be Achieved Safely in a Heterogeneous Pacemaker Population and Provide Clinical Benefits: The CANadian Multi‐Centre Randomised Study‐Spontaneous AtrioVEntricular Conduction pReservation (CAN‐SAVE R) Trial

“…All patients enrolled in the trial received a Symphony DR 2550 cardiac pacemaker (SORIN CRM SAS, Clamart, France) equipped with the SafeR algorithm. Details of this algorithm have been previously described . In summary, SafeR provides AAI(R) pacing while continuously monitoring AV conduction and reverts to DDD(R) pacing when required for AV block of any degree.…”

“…The SafeR algorithm (Sorin CRM, Clamart, France) was developed to provide a pacing mode that combines the benefits of AAI with the safety of DDD pacing . The recent randomized SaveR study confirmed the superiority of SafeR in reducing RV pacing when compared to standard DDD pacing in selected patients without high‐degree AV block and in a more general pacemaker population.…”