Use of a lipid-emulsion carrier for immunisation of dab (Limanda limanda) by bath and oral routes: an assessment of systemic and mucosal antibody responses

Lin, S.-H.; Davidson, G.A.; Secombes, Chris J.; Ellis, A.E.

doi:10.1016/s0044-8486(99)00218-5

Cited by 20 publications

(14 citation statements)

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“…injection. Bath delivery failed to induce any gill responses (Lin et al, 2000). In conclusion, from these two studies, it would appear that gill IgM antibody responses are better stimulated by systemic than mucosal delivery, at least in a HGG model.…”

Section: Mucosal Immune Responsesmentioning

confidence: 99%

“…As shown in Table 5, in most fish studies, when one mucosal immune site secretes specific IgM other MALT sites are also stimulated (Esteve-Gassent et al, 2003; Lin et al, 2000; Merino-Contreras et al, 2001; Swan et al, 2008; Vervarcke et al, 2005; Xu et al, 2009a). The kinetics and potency of the response of each compartment are however different in different experimental models.…”

Section: A Common-mucosal Immune System (Cmis)?mentioning

confidence: 99%

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Mucosal immunoglobulins and B cells of teleost fish

Salinas

Zhang

Sunyer

2011

Developmental & Comparative Immunology

510

366

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As physical barriers that separate teleost fish from the external environment, mucosae are also active immunological sites that protect them against exposure to microbes and stressors. In mammals, the sites where antigens are sampled from mucosal surfaces and where stimulation of naive T and B lymphocytes occurs are known as inductive sites and are constituted by mucosa-associated lymphoid tissue (MALT). According to anatomical location, the MALT in teleost fish is subdivided into gut-associated lymphoid tissue (GALT), skin-associated lymphoid tissue (SALT), and gill-associated lymphoid tissue (GIALT). All MALT contain a variety of leukocytes, including, but not limited to, T cells, B cells, plasma cells, macrophages and granulocytes. Secretory immunoglobulins are produced mainly by plasmablasts and plasma cells, and play key roles in the maintenance of mucosal homeostasis. Until recently, teleost fish B cells were thought to express only two classes of immunoglobulins, IgM and IgD, in which IgM was thought to be the only one responding to pathogens both in systemic and mucosal compartments. However, a third teleost immunoglobulin class, IgT/IgZ, was discovered in 2005, and it has recently been shown to behave as the prevalent immunoglobulin in gut mucosal immune responses. The purpose of this review is to summarise the current knowledge of mucosal immunoglobulins and B cells of fish MALT. Moreover, we attempt to integrate the existing knowledge on both basic and applied research findings on fish mucosal immune responses, with the goal to provide new directions that may facilitate the development of novel vaccination strategies that stimulate not only systemic, but also mucosal immunity.

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Section: Mucosal Immune Responsesmentioning

confidence: 99%

Section: A Common-mucosal Immune System (Cmis)?mentioning

confidence: 99%

Mucosal immunoglobulins and B cells of teleost fish

Salinas

Zhang

Sunyer

2011

Developmental & Comparative Immunology

510

366

View full text Add to dashboard Cite

show abstract

“…Immersion vaccination could effectively activated the systemic and mucosal immunity of teleost and induced a protective immune responses (Grabowski et al, 2004;Lin et al, 2000;Valdenegro-Vega et al, 2013;Liu et al, 2014), which was a convenient and effective approach to control epidemic diseases in aquaculture (Villumsen and Raida, 2013;Sommerset et al, 2005;Plant and LaPatra, 2011;Van Muiswinkel and Nakao, 2014). Previous researches demonstrated that the antigen uptake and immune efficacy would be influenced by many factors, such as temperature, fish age, nutritional status, type of vaccine, physio-chemical characteristics of vaccine solution and immersion formulation (Xu et al, 2011;Soto et al, 2014;Tatner and Horne, 1985).…”

Section: Introductionmentioning

confidence: 99%

Immune response of flounder (Paralichthys olivaceus) was associated with the concentration of inactivated Edwardsiella tarda and immersion time

Tang

Sheng

et al. 2015

Veterinary Immunology and Immunopathology

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“…The delayed onset of antibody formation in the mucosal compartment after IP injection might indicate a delayed exchange from the systemic to the mucosal compartment [16,17]. This suggests that anal and oral immunisation may stimulate the mucosal immune system directly, while after injection a response in the mucosal compartment must await systemic processing of the antigen and initiation of a systemic response [15]. The results obtained provide evidence for the existence of a common mucosal immune system in African catfish.…”

Section: Discussionmentioning

confidence: 79%

“…Since Johnson and Amend showed that anal intubation of Vibrio vaccine was significantly more effective at inducing protection than oral delivery of the vaccine, there have been many attempts to protect antigens delivered orally from the digestive processes in the stomach and anterior intestine [15].…”

Section: Discussionmentioning

confidence: 99%