Use of a gelatin hydrogel membrane containing β-tricalcium phosphate for guided bone regeneration enhances rapid bone formation

Noritake, Kanako; Kuroda, Shinji; Nyan, Myat; Atsuzawa, Yuji; Uo, Motohiro; Ohya, Keiichi; Kasugai, Shohei

doi:10.4012/dmj.2014-123

Cited by 9 publications

(5 citation statements)

References 16 publications

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Section: Discussionmentioning

confidence: 99%

“…Different scaffolds have been utilized as growth factor carriers to optimize bioavailability and increase their half-life. Among these, collagen (9) ,gelatin sponges (10,11) , combination (sandwich membrane) (12) and chitosan (13,14) have been used as vehicles for various growth factors in bone regeneration.However, a membrane prepared from gelatin alone cannot function as a GTR membrane due to its mechanical weakness. To overcome this drawback, βtricalcium phosphate (β-TCP) powder was mixed with gelatin solution, because it is osteoconductive and biodegradable.…”

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confidence: 99%

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Clinical and Radiographic Evaluation of Gelatin/Beta-Tricalcium Phosphate Sponges with or without Concentrated Growth Factor in the treatment of Localized Class II Gingival Recession defects

saeed,

darwish,

saudi

et al. 2024

Preprint

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Background: The aim of this study was to compare, clinically and radiographically, the effectiveness of gelatin sponges loaded with β-tricalcium phosphate with or without concentrated growth factor (Groups I & III) versus collagen with concentrated growth factor (Group II) in the treatment of Miller class II gingival recession. Materials and Methods: Twenty-one sites in 11 patients with Miller class II gingival recession were included in the present study. Sites were allocated randomly to be treated with gelatin sponges loaded with β-tricalcium phosphate with or without concentrated growth factor and collagen with concentrated growth factor. At baseline and, 3, 6 and 12 months after surgery, the following clinical parameters were recorded: recession depth, recession width, pocket depth, clinical attachment level,height of keratinized gingiva, gingival thickness, percentage of root coverage, and digital measurement. Results: All groups showed significant improvement in all clinical parameters and labial bone gain was observed after 12 months compared to baseline measures. Groups II & III showed a statistically significant improvement when compared with Group I, while radiographically the differences in the amount of labial bone gain and volume between groups were not statistically significant at any study period post-treatment. However, there was more bone gain in group III than group II and both groups showed better results than group I. Conclusion: The results of the present study indicated that, gelatin sponges loaded with β-tricalcium phosphate with or without concentrated growth factor (Groups I & III) and collagen with concentrated growth factor (Group II), all led to favorable clinical, and radiographic outcomes. While collagen with concentrated growth factor showed superior clinical results and gelatin sponges loaded with β-tricalcium phosphate with concentrated growth showed superior radiographic results compared to gelatin sponges loaded with β-tricalcium phosphate alone, it was therefore postulated that, the addition of concentrated growth factor may have been a potentiating material, which could have enhanced periodontal tissue repair.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Clinical and Radiographic Evaluation of Gelatin/Beta-Tricalcium Phosphate Sponges with or without Concentrated Growth Factor in the treatment of Localized Class II Gingival Recession defects

saeed,

darwish,

saudi

et al. 2024

Preprint

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“…It has been observed that the GEL based membrane has a faster osteoconductive effect than the Col membrane in the market. The reason is thought to be caused by the combination of GEL and β-TCP [25].…”

Section: Pla and Gel Based Gbr Membrane Case Studiesmentioning

confidence: 99%

A Review Polylactic Acid and Gelatin Biomaterial GBR (Guided Bone Regeneration) and Multilayer GBR Membranes

Kamacı¹,

Yucel²,

Köten³

et al. 2021

Journal of Polytechnic

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“…Histology results confirmed bone formation. However, there was no significant difference in bone volume between the two membranes when compared to the untreated control [115].…”

Section: Application Of Regenerative Scaffold For Bte and Or Regenmentioning

confidence: 99%

The Regenerative Applicability of Bioactive Glass and Beta-Tricalcium Phosphate in Bone Tissue Engineering: A Transformation Perspective

Lowe

Ottensmeyer

et al. 2019

JFB

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The conventional applicability of biomaterials in the field of bone tissue engineering takes into consideration several key parameters to achieve desired results for prospective translational use. Hence, several engineering strategies have been developed to model in the regenerative parameters of different forms of biomaterials, including bioactive glass and β-tricalcium phosphate. This review examines the different ways these two materials are transformed and assembled with other regenerative factors to improve their application for bone tissue engineering. We discuss the role of the engineering strategy used and the regenerative responses and mechanisms associated with them.

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Use of a gelatin hydrogel membrane containing β-tricalcium phosphate for guided bone regeneration enhances rapid bone formation

Cited by 9 publications

References 16 publications

Clinical and Radiographic Evaluation of Gelatin/Beta-Tricalcium Phosphate Sponges with or without Concentrated Growth Factor in the treatment of Localized Class II Gingival Recession defects

Clinical and Radiographic Evaluation of Gelatin/Beta-Tricalcium Phosphate Sponges with or without Concentrated Growth Factor in the treatment of Localized Class II Gingival Recession defects

A Review Polylactic Acid and Gelatin Biomaterial GBR (Guided Bone Regeneration) and Multilayer GBR Membranes

The Regenerative Applicability of Bioactive Glass and Beta-Tricalcium Phosphate in Bone Tissue Engineering: A Transformation Perspective

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