Use of a dot enzyme-linked immunosorbent assay on absorbed sera for the diagnosis of bovine paratuberculosis

Bech-Nielsen, S; Wp, Shulaw; Pl, Frandsen; Jb, Jørgensen; Ahrens, Peter; Nc, Feld

doi:10.20506/rst.12.2.697

Cited by 2 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…27,76 CMI responses are usually replaced by antibody mediated responses in animals with multibacillary lesions. 38,56,58,73,[77][78][79][80][81][82][83][84][85][86] Multibacillary cases and hence heavy faecal shedders are more likely to test positive in serological tests than early or pauci-bacillary cases. 72,75,80,81,83,84,86,87 Positive results in serological tests may be intermittent 88 but tend to become stronger as the disease progresses.…”

Section: Morphological Changes In the Intestinal Wallmentioning

confidence: 99%

Progress towards understanding the spread, detection and control of Mycobacterium avium subsp para‐tuberculosis in animal populations

2001

View full text Add to dashboard Cite

Paratuberculosis, a chronic enteropathy of ruminants, is caused by Mycobacterium avium subsp paratuberculosis and is transmitted mainly in faeces to young animals by infected adults, some of which may not have clinical signs. The incubation period is inversely related to the size of the challenge dose but can be extremely prolonged. Clinical cases may not be seen within the economic lifespan of farm animals, particularly when stocking rates are low, pasture is spelled, or when animals are culled at a relatively young age. Other as yet unknown influences may determine the rate of progression or recovery from infection. Paratuberculosis appears in a range of forms from a disease with high prevalence and significant mortality through to one with very low prevalence and little obvious morbidity or mortality. Detection of infected flocks and herds relies on use of laboratory tests. Bacteriological culture of faeces is the most sensitive herd-level test. The passage of time and repeated testing are the greatest allies in detecting paratuberculosis because infected animals progress in the disease process and most tests are more effective in the later stages of the disease. These factors generally cause the prevalence of paratuberculosis to be underestimated at both herd or flock and regional level. Greater understanding of the epidemiology and pathogenesis of M a paratuberculosis infection is critical in order to design improved diagnostic strategies, assess the feasibility of eradication and develop control options, particularly in small ruminants.

show abstract

Section: Morphological Changes In the Intestinal Wallmentioning

confidence: 99%

Progress towards understanding the spread, detection and control of Mycobacterium avium subsp para‐tuberculosis in animal populations

2001

View full text Add to dashboard Cite

show abstract

Mycobacterium aviumsubsp.paratuberculosisin Veterinary Medicine

2001

View full text Add to dashboard Cite

Mycobacterium avium subsp. paratuberculosis (basonym M. paratuberculosis) is the etiologic agent of a severe gastroenteritis in ruminants known as Johne's disease. Economic losses to the cattle industry in the United States are staggering, reaching $1.5 billion annually. A potential pathogenic role in humans in the etiology of Crohn's disease is under investigation. In this article, we review the epidemiology, pathogenesis, diagnostics, and disease control measures of this important veterinary pathogen. We emphasize molecular genetic aspects including the description of markers used for strain identification, diagnostics, and phylogenetic analysis. Recent important advances in the development of animal models and genetic systems to study M. paratuberculosis virulence determinants are also discussed. We conclude with proposals for the applications of these models and recombinant technology to the development of diagnostic, control, and therapeutic measures

show abstract

Use of a dot enzyme-linked immunosorbent assay on absorbed sera for the diagnosis of bovine paratuberculosis

Cited by 2 publications

References 9 publications

Progress towards understanding the spread, detection and control of Mycobacterium avium subsp para‐tuberculosis in animal populations

Progress towards understanding the spread, detection and control of Mycobacterium avium subsp para‐tuberculosis in animal populations

Mycobacterium aviumsubsp.paratuberculosisin Veterinary Medicine

Contact Info

Product

Resources

About