Use of a Digestive Mucosal
Graft in Urethroplasty

Lebrét, Thierry; Gobet, Françoise; Dallaserra, M.; Mitrofanoff, P

doi:10.1159/000475125

Cited by 14 publications

(5 citation statements)

References 4 publications

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“…Bladder mucosa grafts have been associated with glandular protrusion of bladder epithelium causing secondary meatal stenosis and urinary obstruction 14–16 . The need for more satisfactory alternative tissues for use as urethral substitutes has led others to study the use of intestinal submucosa, 17 vascularized tunica vaginalis flaps, 18 and free colonic mucosa 19 in experimental models.…”

Section: Introductionmentioning

confidence: 99%

Repair of Urethral Defects Using Fascia Lata Autografts in Dogs

et al. 2005

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Section: Introductionmentioning

confidence: 99%

Repair of Urethral Defects Using Fascia Lata Autografts in Dogs

et al. 2005

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“…Multiple graft substrates have been used over the years including buccal, lingual, penile, and scrotal grafts although buccal grafts have remained the most widely used. Reports of using bowel mucosa for substitution urethroplasty date back to 1994 when Lebret et al reported using appendiceal mucosa (1,2). Xu et al first reported using tubularized colonic mucosa in 2003 for the repair of recurrent urethral strictures (3,4).…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, histologic studies of colonic mucosa exposed previously to urine demonstrated the ability of the colonic mucosa to adapt as a non-secreting urothelium (2). In Palmer et al ’s early report of using rectal mucosal substitution grafts, patients selected for the study were those with long urethral strictures, primarily secondary to lichen sclerosus, with median stricture length of 13.5 cm (5).…”

Section: Introductionmentioning

confidence: 99%

Use of rectal mucosal grafts in substitution urethroplasty: an early series

Monn

Waters

Mellon

2018

Transl. Androl. Urol

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BackgroundTo evaluate the feasibility of use of rectal mucosal grafts for augmentation urethroplasty.MethodsA series of five patients who underwent rectal mucosal graft urethroplasty for urethral stricture disease were identified. Descriptive statistics were used to describe these patients. Primary endpoints were recurrence of stricture and perioperative morbidity.ResultsFive patients underwent rectal mucosal graft augmentation urethroplasty. Four had a history of prior buccal mucosal graft (BMG) urethroplasty and one had a history of head and neck cancer. Rectal mucosa was noted to be thinner and required more tailoring than buccal mucosa. All patients had patent urethras at time of postoperative retrograde urethrogram. A small diverticulum was noted in one patient with no further sequelae. No complications from rectal mucosal graft harvest were noted. All patients with prior buccal grafting subjectively preferred the rectal graft due to fewer side effects. Subjectively, patients with prior buccal grafts preferred the post-operative recovery following rectal mucosal graft urethroplasty.ConclusionsRectal mucosal graft augmentation urethroplasty is a safe alternative in patients with contraindications to buccal grafting with limited morbidity.

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“…Urethral reconstruction is a challenge for reconstruc-tive surgeons. For this aim, skin [1], oral mucosa [2,3], bladder mucosa [4,5], digestive mucosa [6], peritoneum [7], vein grafts [8,9] and preputial tissue flaps [10] have been used. Among these, mucosa and skin grafts and preputial tissue are probably the most popular.…”

Section: Introductionmentioning

confidence: 99%