Use of a Desk-Top Computer in a Search-Type Optimization of Tablet Formulations

Down, Geoff; Miller, Robert A.; Chopra, Shruti; Millar, J.F.

doi:10.3109/03639048009068708

Cited by 11 publications

(1 citation statement)

References 3 publications

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“…The basic theory of factorial designed experiments and its application to pharmaceutics has been thoroughly investigated by Sucker (1971). Different methods of optimization have been reported using computers as an aid to simplify their application (Schwartz et al 1973, Bohidar et al 1979, Down et al 1980. As the number of factors is increased the number of experiments required increases dramatically.…”

Section: Introductionmentioning

confidence: 98%

Optimization of a fluid bed spray coating process using reduced factorial design

Johansson¹,

Ringberg²,

Nicklasson³

1987

Journal of Microencapsulation

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A sequential approach to the optimization of a fluid bed coating process of pellets for controlled release using organic solvents and ethylcellulose has been applied using reduced factorial experiments. The optimization was started by applying a 2(4-1) experiment then, based on the results from that study, further experiments were carried out where only the variables which had the most significant effect on the film yield were used. Finally, a 2(3-1) experiment was performed. A relationship was found between the film yield and degree of agglomeration, indicating a limiting value of the film yield (75 per cent) below which only little agglomeration takes place. Above this value, the degree of agglomeration increases dramatically. The limit value was found to change only to a minor extent as a function of experimental conditions.

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Section: Introductionmentioning

confidence: 98%