Effect of Compressional Force on Tablets Containing Cellulosic Disintegrators I: Dimensionless Disintegration Values

Vadas, Elizabeth B.; Down, G.R.B.; Miller, Robert A.

doi:10.1002/jps.2600730618

Cited by 12 publications

(5 citation statements)

References 4 publications

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“…The starches were incorporated extra‐granularly into paracetamol tablet formulation and the crushing strength, friability, and disintegration times were evaluated. The disintegrant efficiency ratio, DER, and the dimensionless quantities, T C and T N , which have been used to describe the activities and efficiency of different disintegrants in formulation in comparison to the standard/control disintegrant, was used to compare the activity of the disintegrants . These quantities permit direct comparison of trends in tablet behavior with compressional force or any other variable affecting disintegration time .…”

Section: Introductionmentioning

confidence: 99%

“…The disintegrant efficiency ratio, DER, and the dimensionless quantities, T C and T N , which have been used to describe the activities and efficiency of different disintegrants in formulation in comparison to the standard/control disintegrant, was used to compare the activity of the disintegrants . These quantities permit direct comparison of trends in tablet behavior with compressional force or any other variable affecting disintegration time . While T C measures the disintegrant efficiency in comparison to the standard disintegrant, T N measures the disintegrant efficiency within a batch, i.e ., tablets with different relative densities.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the disintegrant properties of native and modified forms of fonio and sweet potato starches

2015

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The effects of acid modification on the disintegrant properties of two native starches obtained from Digitaria exilis (white fonio) and Ipomea batatas (sweet potato) were evaluated in comparison with official corn starch in paracetamol tablet formulations. The starches were extracted from grains of white fonio and tubers of sweet potato, and modified by acid hydrolysis using 6% w/w hydrochloric acid for 48 h. The native and modified forms of the starches were employed as exo-disintegrants in paracetamol tablet formulations at concentrations of 2.5, 5.0, and 10.0% w/w. The disintegrant properties were assessed using crushing strength (C s ), friability (F r ), disintegration time (D T ), disintegrant efficiency ratio (DER), and the dimensionless quantity DER c . The results showed that crushing strength and friability of the tablets appeared to depend on the type, concentration, and nature of disintegrant used. Disintegration time generally decreased with increase in disintegrant concentration and the values complied with the pharmacopoeial standard for uncoated tablets ( 15 min). Tablets containing acid modified starches showed longer disintegration times than those containing the native starches although there were no significant differences (p > 0.05) in the values. Acid modification generally increased the disintegration efficiency ratio (DER) of the formulations while the values of DER c indicated that sweet potato starch would be the most efficient disintegrant with greater ability to enhance the balance between the mechanical and disintegration properties of the tablet. Thus, the experimental starches compared well with corn starch as disintegrants and could be useful for commercial tablet formulations.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the disintegrant properties of native and modified forms of fonio and sweet potato starches

2015

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“…Disintegration time has been shown to depend on type and percentage of drug and additives and on tablet manufacturing. [1][2][3] The swelling of disintegrant particles remains the only demonstrated mechanism of tablet disintegration. 4,5 In fact, the water taken up by disintegrant particles generates a force inside the tablet.…”

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confidence: 99%

The suitability of disintegrating force kinetics for studying the effect of manufacturing parameters on spironolactone tablet properties

et al. 2003

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The aim of this paper was to study the effect of the granulate properties and tablet compression force on disintegrating force behavior in order to investigate the capability of the disintegrating force to characterize tablets that have the same composition but were manufactured in different conditions. Several tablets containing spironolactone in the external or internal granulated mixture of calcium carbonate and maize starch differing in particle size distribution, were prepared at 3 compression levels. The force developed by tablets during water uptake and disintegration was measured and plotted versus time. The curves obtained were analyzed by the Weibull equation in order to calculate the parameters characterizing the tablet disintegration kinetics. The disintegrating force time parameter, the maximum force developed, and the area under the curve were determined. In general, the reduction of time parameter value and/or the increase in maximum force developed corresponded to an acceleration in tablet disintegration. In addition, the area under the force curve increased in stronger tablets, monitoring in a sensitive way the tablet structural changes introduced by compression force. The results showed that the disintegrating force measurement can detect small changes in the structure of the tablet that cannot be discriminated by pharmacopoeia tests. The effect of manufacturing, in particular compression force, on tablet properties was quantified by the parameters of disintegrating force kinetics.

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“…(Guyot-Hermann and Ringard, 1981) It has been shown that Sodium starch glycolate (SSG) can influence the disintegration time of acetaminophen tablets depending on whether gastric juice or water is used as the medium. [14] and Vadas et al (1984) [15] confirmed that croscarmellose sodium was insensitive to change of pH of medium. To characterize the drug release rate in different experimental conditions,T 25% , T 50% (mean dissolution time) and T 80% were calculated from dissolution data according to the following equations: T 25% = (0.25/k) 1/n , T 50% = (0.5/k) 1/n , T 80% = (0.8/k) 1/n where K is the kinetic constant and n is the exponent that characterize the mechanism of drug release.…”

Section: Introductionmentioning

confidence: 65%

Synergistic Effects of Disintegrants on Release of poorly Water soluble drug

Rahman

Khalpha

Chaurasiya

et al. 2012

Int. J. Pharma Life Sci.

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We have done research work in lab to find out proper formulation of immediate release tablet by using of various types of disintegrants (crospovidone, sodium starch glycolate and sodium carboxymethylcellulose), in order to examine the effect of mode of absorption of disintegrants on release mechanism from tablets. Acetaminophen, a poor soluble drug was used as a model drug to estimate its release pattern from different formulations. The USP paddle method was selected to perform the dissolution profiles carried out by USP apparatus 2 (paddle) at 50 rpm in 900 ml phosphate buffer pH 5.8. Successive dissolution time, time required for 25%, 50% and 80% of the drug release (T25%, T50%, T80%) was used to evaluate the dissolution results. A One way analysis of variance (ANOVA) was used to recognize the result. Statistically significant differences were found among the drug release profile from all the formulations except mode of addition of crosspovidone. At a fixed amount of disintegrants, extragranular mode of addition seemed to be the best mode of incorporation. The best release was achieved with the sodium carboxymethylcellulose and sodium starch glycolate containing formulations. The T50 and T80 values were analytical of the fact that the drug release was faster from tablet formulations containing carboxymethylcellulose and sodium starch glycolate. The drug release was very much negligible difference by the mode of crospovidone addition. Two formulations found very small T50 and T80 values indicating very much faster release. From the all formulations corresponded extragranular mode of addition could be the best mode of incorporation. The drug release was unaffected by the mode of crospovidone addition. The mode of incorporation of disintegrants suggested enchancing the release of poor soluble drugs. DOI: http://dx.doi.org/10.3329/ijpls.v1i3.12979 International Journal of Pharmaceutical and Life Sciences Vol.1(3) 2012

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Effect of Compressional Force on Tablets Containing Cellulosic Disintegrators I: Dimensionless Disintegration Values

Cited by 12 publications

References 4 publications

Evaluation of the disintegrant properties of native and modified forms of fonio and sweet potato starches

Evaluation of the disintegrant properties of native and modified forms of fonio and sweet potato starches

The suitability of disintegrating force kinetics for studying the effect of manufacturing parameters on spironolactone tablet properties

Synergistic Effects of Disintegrants on Release of poorly Water soluble drug

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