Use of 25-hydroxycholecalciferol in Diets of Broiler Chickens: Effects on Growth Performance, Immunity and Bone Calcification

Gómez-Verduzco, Gabriela; Morales-López, R.; Avila-Gozàlez, Ernesto

doi:10.2141/jpsa.0120071

Cited by 31 publications

(14 citation statements)

References 27 publications

(31 reference statements)

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“…(2009) indicated that a supplementation of 25-OH-D 3 could enhance humoral immune responses in challenged broilers. Gomez-Verduzco et al. (2013) indicated that the supplementation of dietary high levels of cholecalciferol (2,000 IU/kg) in comparison with the levels recommended by NRC (1994) enhanced the antibody titer against NDV, and the supplementation of 25-OH-D 3 enhanced the cellular immunity of broiler chickens.…”

Section: Discussionmentioning

confidence: 98%

Effects of dietary 1 alpha-hydroxycholecalciferol in calcium and phosphorous-deficient diets on growth performance, tibia related indices and immune responses in broiler chickens

2019

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This experiment was conducted to investigate the effect of dietary 1α-hydroxycholecalciferol (1α-OH-D 3 ) in calcium (Ca)- and phosphorous (P)-deficient diets on growth performance, carcass characteristics, tibia related parameters, and immune responses of broiler chickens. A total of 280 one-day-old broiler chickens (Ross 308) were assigned to 20 floor pens and 4 dietary treatments with 5 replicates. Dietary treatments consisted of starter diets (starter diet of treatment A: 1% Ca, 0.73% total phosphorus [tP]; starter diet of treatment B: 0.85% Ca, 0.64% tP + 5 μg/kg of 1α-OH-D 3 ; starter diet of treatment C: 0.85% Ca, 0.59% tP + 5 μg/kg of 1α-OH-D 3 ; starter diet of treatment D: 0.85% Ca, 0.54% tP + 5 μg/kg of 1α-OH-D 3 ), grower diets (grower diet of treatment A: 0.86% Ca, 0.68% tP; grower diet of treatment B: 0.73% Ca, 0.59% tP + 5 μg/kg of 1α-OH-D 3 ; grower diet of treatment C: 0.73% Ca, 0.55% tP + 5 μg/kg of 1α-OH-D 3 ; grower diet of treatment D: 0.73% Ca, 0.50% tP + 5 μg/kg of 1α-OH-D 3 ) and finisher diets (finisher diet of treatment A: 0.81% Ca, 0.64% tP; finisher diet of treatment B: 0.68% Ca, 0.56% tP + 5 μg/kg of 1α-OH-D 3 ; finisher diet of treatment C: 0.68% Ca, 0.52% tP + 5 μg/kg of 1α-OH-D 3 ; finisher diet of treatment D: 0.68% Ca, 0.48% tP + 5 μg/kg of 1α-OH-D 3 ). Results showed that body weight gain (BWG) and feed intake (FI) of broilers in treatment B were similar to those of broilers in treatment A at the end of the trial ( P < 0.05). Broilers in treatments C and D had lower BWG and FI than those in treatment A during the whole trial ( P < 0.05). Feed conversion ratio, carcass traits and relative weight of lymphoid organs were not affected by dietary treatments ( P > 0.05). Dietary treatments had no significant effect on antibody titers against Newcastle and Influenza disease viruses as well as sheep red blood cells. Dietary treatments had no significant effects on tibia ash and tibial dyschondroplasia score. Broilers fed Ca-P deficient diets had lower tibia Ca and P than those in treatment A ( P < 0.05). In conclusion, results indicated that broilers fed Ca-P deficient diets supplemented with 5 μg/kg 1α-OH-D 3 failed to achieve the same tibia Ca and P values as broilers fed nonphytate phosphorus adequate diets.

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Section: Discussionmentioning

confidence: 98%

Effects of dietary 1 alpha-hydroxycholecalciferol in calcium and phosphorous-deficient diets on growth performance, tibia related indices and immune responses in broiler chickens

2019

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“…In chickens, Vit-D 3 and its analogues play an immunomodulatory role in the immune system both in vivo and vitro . In particular, vitamin D-deficiency decreases cutaneous basophil hypersensitivity response to phytohemagglutinin-P [ 32 ], while adding extra 25OHD 3 to diets enhances both the humoral immune response and cell-mediated immune response [ 33 ]. Simultaneously, MQ-NCSU cells treated with 1,25D 3 display increased production of nitric oxide and decreased expression of IL-1β as well as chemokine ligand 8 in the presence of LPS [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

1,25-Dihydroxyvitamin-D3 Induces Avian β-Defensin Gene Expression in Chickens

Zhang

et al. 2016

PLoS ONE

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Host defense peptides (HDPs) play a critical role in innate immunity. Specific modulation of endogenous HDP synthesis by dietary compounds has been regarded as a novel approach to boost immunity and disease resistance in animal production. 1,25-dihydroxy vitamin D3 (1,25D3) is well known as a powerful HDP inducer in humans, but limited information about the effect of 1,25D3 on HDPs in poultry is available. Here, we sought to examine whether 1,25D3 could stimulate avian β-defensin (AvBD) expression in chickens. We used chicken embryo intestinal epithelial cells (CEIEPCs) and peripheral blood mononuclear cells (PBMCs) to study the effect of 1,25D3 on the expression of AvBDs. We observed that 1,25D3 is able to up-regulate the expression of several AvBDs in CEIEPCs and PBMCs, whereas it increased the amounts of AvBD4 mRNA in CEIEPCs only in the presence of lipopolysaccharide (LPS). On the other hand, LPS treatment not only inhibited the expression of CYP24A1 but also altered the expression pattern of VDR in CEIEPCs. Furthermore, AvBDs were not directly regulated by 1,25D3, as cycloheximide completely blocked 1,25D3-induced expression of AvBDs. Our observations suggest that 1,25D3 is capable of inducing AvBD gene expression and is a potential antibiotic alternative through augmentation of host innate immunity as well as disease control in chickens.

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“…It is widely known that some micronutrients, such as vitamins and minerals, may enhance humoral and cellular immune response. Considering the effect of vitamins, Gómez-Verduzco et al [ 149 ] stated that high levels of vitamin D 3 might be able to improve antibody and cellular immune response. Also dietary vitamin E could have an immunomodulatory effect particularly on CD4+/CD8- T cells in thymus and spleen [ 150 ] and might increase macrophage phagocytic activity during the early stages of broiler growth [ 151 ].…”

Section: Disease Resistancementioning

confidence: 99%

Application of omics technologies for a deeper insight into quali-quantitative production traits in broiler chickens: A review

Zampiga

Flees

Meluzzi

et al. 2018

J Animal Sci Biotechnol

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The poultry industry is continuously facing substantial and different challenges such as the increasing cost of feed ingredients, the European Union’s ban of antibiotic as growth promoters, the antimicrobial resistance and the high incidence of muscle myopathies and breast meat abnormalities. In the last decade, there has been an extraordinary development of many genomic techniques able to describe global variation of genes, proteins and metabolites expression level. Proper application of these cutting-edge omics technologies (mainly transcriptomics, proteomics and metabolomics) paves the possibility to understand much useful information about the biological processes and pathways behind different complex traits of chickens. The current review aimed to highlight some important knowledge achieved through the application of omics technologies and proteo-genomics data in the field of feed efficiency, nutrition, meat quality and disease resistance in broiler chickens.

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Use of 25-hydroxycholecalciferol in Diets of Broiler Chickens: Effects on Growth Performance, Immunity and Bone Calcification

Cited by 31 publications

References 27 publications

Effects of dietary 1 alpha-hydroxycholecalciferol in calcium and phosphorous-deficient diets on growth performance, tibia related indices and immune responses in broiler chickens

Effects of dietary 1 alpha-hydroxycholecalciferol in calcium and phosphorous-deficient diets on growth performance, tibia related indices and immune responses in broiler chickens

1,25-Dihydroxyvitamin-D3 Induces Avian β-Defensin Gene Expression in Chickens

Application of omics technologies for a deeper insight into quali-quantitative production traits in broiler chickens: A review

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