Effects of dietary 1 alpha-hydroxycholecalciferol in calcium and phosphorous-deficient diets on growth performance, tibia related indices and immune responses in broiler chickens

Abstract

This experiment was conducted to investigate the effect of dietary 1α-hydroxycholecalciferol (1α-OH-D 3 ) in calcium (Ca)- and phosphorous (P)-deficient diets on growth performance, carcass characteristics, tibia related parameters, and immune responses of broiler chickens. A total of 280 one-day-old broiler chickens (Ross 308) were assigned to 20 floor pens and 4 dietary treatments with 5 replicates. Dietary treatments consisted of starter diets (starter diet of treatment A: 1% Ca, 0.73% total phosphorus [tP]; starter diet of treatment B: 0.85% Ca, 0.64% tP + 5 μg/kg of 1α-OH-D 3 ; starter diet of treatment C: 0.85% Ca, 0.59% tP + 5 μg/kg of 1α-OH-D 3 ; starter diet of treatment D: 0.85% Ca, 0.54% tP + 5 μg/kg of 1α-OH-D 3 ), grower diets (grower diet of treatment A: 0.86% Ca, 0.68% tP; grower diet of treatment B: 0.73% Ca, 0.59% tP + 5 μg/kg of 1α-OH-D 3 ; grower diet of treatment C: 0.73% Ca, 0.55% tP + 5 μg/kg of 1α-OH-D 3 ; grower diet of treatment D: 0.73% Ca, 0.50% tP + 5 μg/kg of 1α-OH-D 3 ) and finisher diets (finisher diet of treatment A: 0.81% Ca, 0.64% tP; finisher diet of treatment B: 0.68% Ca, 0.56% tP + 5 μg/kg of 1α-OH-D 3 ; finisher diet of treatment C: 0.68% Ca, 0.52% tP + 5 μg/kg of 1α-OH-D 3 ; finisher diet of treatment D: 0.68% Ca, 0.48% tP + 5 μg/kg of 1α-OH-D 3 ). Results showed that body weight gain (BWG) and feed intake (FI) of broilers in treatment B were similar to those of broilers in treatment A at the end of the trial ( P < 0.05). Broilers in treatments C and D had lower BWG and FI than those in treatment A during the whole trial ( P < 0.05). Feed conversion ratio, carcass traits and relative weight of lymphoid organs were not affected by dietary treatments ( P > 0.05). Dietary treatments had no significant effect on antibody titers against Newcastle and Influenza disease viruses as well as sheep red blood cells. Dietary treatments had no significant effects on tibia ash and tibial dyschondroplasia score. Broilers fed Ca-P deficient diets had lower tibia Ca and P than those in treatment A ( P < 0.05). In conclusion, results indicated that broilers fed Ca-P deficient diets supplemented with 5 μg/kg 1α-OH-D 3 failed to achieve the same tibia Ca and P values as broilers fed nonphytate phosphorus adequate diets.

Dietary supplementation with canthaxanthin and 25-hydroxycholecalciferol on the incubation performance and fertility of European quail breeders

“…Overall, these results show that to improve embryonic mortality rates, diets must contain an optimal ratio of vitamin D 3 to 25-OH-D 3 . The possible interaction between vitamin D 3 and 25-OH-D 3 observed in this study, corroborate with Ghasemi et al (2019) that reported the possibility of have been an interaction between vitamin D 3 and 1α-cholecalciferol. In the current study, the quadratic dependence of most parameters on Cx + 25-OH-D 3 levels demonstrates the importance of defining the adequate Cx + 25-OH-D 3 concentration.…”

Dietary Lactobacillus fermentum and Lactobacillus paracasei improve the intestinal health of broilers challenged with coccidia and Clostridium perfringens

“…It was accepted that calcium contributed to the performance and immunity of poultry ( 27 , 28 ). In the present study, dietary LP elevated the level of calcium in the serum.…”

The effects of 1a(OH)D3 individually or in combination with phytase, and different levels of cholecalciferol on performance, tibia criteria, and plasma minerals of Japanese quails

“…Commonly, vitamin D3 has been consumed in birds such as chickens, turkeys, ducks, and geese nutrition as a forebear for calcitriol. In recent years however, vitamin D metabolites such as 25 hydroxycholecalciferol (25-OHD3) has been successfully consumed in bird's nutrition.After the successful commercialization processof 25-OHD3, there has been more fondness from poultry nutritionist to test the possibility of supplementing1-alpha-hydroxycholecalciferol (1-α(OH)D3) as a precursor for calcitriol (Ghasemi, Toghyani, & Landy, 2018;Landy & Toghyani 2014).Edwards Junior, Shirley, Escoe, and Pesti, (2002) evaluated the possibility of using 1 -α(OH)D3 as a replacement for cholecalciferol in broiler chicken nutrition; the results indicated that the activity of 1 -α(OH)D3 is nearlyeight times as effective as cholecalciferol. Similarly, Landy and Toghyani, (2014) reported that substitution of 5,000 IU cholecalciferol kg -1 of diet with 5 μg of 1-α(OH)D3 kg -1 of diet resulted in better performance and tibia quality of broiler chickens.…”