Use of 24-Hour Urinary Protein and Calcium for Prediction of Preeclampsia

Sirohiwal, Daya; Dahiya, Kiran; Khaneja, Neha

doi:10.1016/s1028-4559(09)60268-0

Cited by 13 publications

(10 citation statements)

References 11 publications

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“…Women with lower dietary milk intake showed an increasing rate of preeclampsia 7 . These results were confirmed by other studies [7][8][9][10] , and led to the hypothesis that an increase in calcium intake during pregnancy can prevent the high blood pressure and preeclampsia. High blood pressure in women with low calcium intake can stimulate parathyroid hormone, causing rennin release, or increasing intracellular calcium in vascular smooth muscle to induce vasoconstriction 11 .…”

Section: Introductionsupporting

confidence: 76%

Calcium supplementation in pregnancy and prevention of hypertensive disorders in elderly women

Aghamohammadi¹,

Zafari²

2015

ScienceAsia

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Preeclampsia is a major cause of maternal and neonatal death and morbidity. Elderly women are at high risk for this complication. This study assesses the effect of calcium supplementation during pregnancy on preeclampsia in women aged over 35. Singleton healthy pregnant women over 35 with a normal blood pressure were randomly assigned to receive 1000 mg/day of elemental calcium or placebo between the 18th and 20th weeks. From 89 women recruited in this study, 5 women in the calcium group and 4 women in the placebo group were excluded during the treatment as it was not possible to follow up their status. Finally, 80 women completed this study and were followed up until delivery. The incidence of preeclampsia was assessed in these 80 women (40 women in placebo and 40 women in the calcium group). The incidence of preeclampsia was significantly lower in the calcium group (15%) than in the placebo group (35%) (p = 0.035). Calcium supplementation appears to reduce the occurrence of preeclampsia and its related preterm birth in women singletons.

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Section: Introductionsupporting

confidence: 76%

Calcium supplementation in pregnancy and prevention of hypertensive disorders in elderly women

Aghamohammadi¹,

Zafari²

2015

ScienceAsia

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“…Hypertensive disorder complicates pregnancy and form one aspect of the deadly triad along with haemorrhage and infection and result in significant maternal morbidity and mortality [1].…”

Section: Introductionmentioning

confidence: 99%

A Prospective Study for the Prediction of Preeclampsia with Urinary Calcium Level

Pal

Roy

Adhikary

et al. 2012

J Obstet Gynecol India

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Objectives To assess the efficacy of calciuria as a diagnostic test for the prediction of preeclampsia, and also to determine the changes in urinary excretion of calcium in preeclampsia and normotensive women. Methods A prospective study was conducted on 60 primi mothers in the age group of 20-30 years, and all were enrolled at 16 weeks of gestation with clinical follow up by 4 weeks and 24 h urinary calcium and creatinine estimation. Ten mothers developed preeclampsia (study groups) and fifty remained normotensive (control groups). By means of Receiver-operator curve, a cut-off level of urinary calcium in 24 h was chosen for predicting preeclampsia. Results Preeclamptic women excreted significantly less total urine calcium (87.0 ± 3.59 mg/24 h) than normotensive women (303.68 ± 17.699 mg/24 h) (p \ 0.0001) at 40 weeks of gestation. Urinary calcium and calcium/ creatinine (Ca:Cr) ratio decreases progressively from 28 weeks to 40 weeks in the study group when compared to normotensive group. Conclusions Preeclamptic women excrete less calcium than normotensive women. This parameter would predict preeclampsia earlier in pregnancy.

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“…Consistent with this study, another study done by Jafrin et al [37] revealed significant decrease in serum calcium in subjects with pre-eclampsia compared to normal pregnant women. Sirohiwal et al [41] reported that compared to normotensive women, the hypertensive women had significantly lower urinary calcium excretion in the study which was done to know the efficacy of measurement of 24 hour urinary protein and calcium for the prediction of preeclampsia in second trimester. It was found that a decrease in 24 hour urinary calcium between 20-28 weeks gestation was predictive of preeclampsia later.…”

Section: Urinary/serum Calcium As Diagnostic/predictor Of Hdspmentioning

confidence: 99%

Role of Calcium in Hypertensive Disorders of Pregnancy Current Status of Research a Mini Review

Chhabra¹

2017

J Nutr Disorders Ther

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Introduction: Some studies have revealed changes in blood/urinary calcium with inverse relationship between calcium intakes during pregnancy, incidence of preeclampsia. So researchers believe that calcium has a role in etiology of hypertensive disorders during pregnancy. With reduced incidence of preeclampsia after calcium supplementation. So prevention of HDsP and/or their severity are being attempted through oral calcium. Objective: To collect existing information about role of calcium in HDsP for translational program or if needed, research. Material Methods: Present article is based on literature search by available search engines like, Pubmed, Google, Update and others. Studies, reviews and short commentaries were looked into to get desired information. Serum urinary cellular calcium: Normally there is increase in intracellular calcium in pregnancy. It has been reported that this effect is exaggerated in preeclampsia due to significant increase in the membranous calcium content. Researchers also reported that preeclampsia in third trimester was associated with hypocalciuria due to increased tubular reabsorption of calcium. Urinary calcium excretion has been found to be reduced in severe preeclampsia, eclampsia, but decrease could not be used to identify severity of preeclampsia, or predict impending eclampsia. Problem seems to be at the cellular level, needs to be investigated further. Calcium supplementation: Some have reported incidence of preeclampsia greater in women given placebo, compared to calcium-treated, although difference was not significant. Also supplementing calcium in women at high risk of pre-eclampsia was likely to reduce incidence of disease. But others reported that extra calcium did not reduce number of women who suffered, however reduced severity of HDsP. Also smooth-muscle relaxation detected in calcium supplemented women might affect labour onset. Conclusion: There are reports of positive relationship and no effect on reduction in HDsP or their severity. In view of contradictory findings, in depth studies are required to investigate altered serum, urine and cellular calcium, in women with HDsP.

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Use of 24-Hour Urinary Protein and Calcium for Prediction of Preeclampsia

Abstract: A decrease in 24-hour urinary calcium and increase in protein between 20-28 weeks' gestation are risk factors for preeclampsia.

Cited by 13 publications

References 11 publications

Calcium supplementation in pregnancy and prevention of hypertensive disorders in elderly women

Calcium supplementation in pregnancy and prevention of hypertensive disorders in elderly women

A Prospective Study for the Prediction of Preeclampsia with Urinary Calcium Level

Role of Calcium in Hypertensive Disorders of Pregnancy Current Status of Research a Mini Review

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